Addiction Audio


Cannabis, schizophrenia and genetics with Emma Johnson

Ep. 31

Dr Emma Johnson talks to Rob Calder about shared genetic liabilities for cannabis use disorder and schizophrenia and the role of tobacco smoking. Dr Johnson talks about the implications of this research on the evidence for a causal relationship between cannabis and schizophrenia and for other genetic associations relating to substance use and psychiatric disorders. The episode also covers to ever-fascinating issue of mendelian randomisation.

(Be sure to check out episode 22 too!)

Johnson E.C., Hatoum A.S., Deak J.D., Polimanti R, Murray R.M., Edenberg H.J., et al. The relationship between cannabis and schizophrenia: a genetically informed perspective. Addiction 2021

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Brief interventions, emergency departments, and alcohol with Paolo Deluca

Season 1, Ep. 43
In this episode of the Addiction Audio podcast, Dr Paolo Deluca talks about his recent research on using brief interventions in emergency departments.The research involved a three-armed randomised controlled trial on brief interventions for young people, and found no significant differences in alcohol-related outcomes between young people who had been given a brief intervention and those who had not. In the podcast, Paolo reflects on some of the potential reasons for this, considering previous evidence in support of brief interventions.“When you move away from an efficacy trial or a single site study where you have highly trained professionals or practitioners delivering the interventions and you move into the real-world NHS setting is where you tend to lose some of the effectiveness you might have had in the early stages of the brief intervention.”Paolo also talks about the core components of brief interventions that can be delivered in 10 minutes in busy emergency departments, and discusses some of the logistical and ethical challenges of recruiting young people to a three-armed trial.“We involved 10 emergency departments, and we ran it for around 8 months and were recruiting from 10am to 10pm in the afternoon and we were covering 7 days a week. To achieve that we had essentially an army of researchers.”Original article: Effectiveness and cost-effectiveness of face-to-face and electronic brief interventions versus screening alone to reduce alcohol consumption among high risk adolescents presenting to Emergency Departments: three-arm pragmatic randomised trial (SIPS Junior High Risk Trial). By Paolo Deluca and colleagues. Published in Addiction (2022).