Talking Techniques


CRISPR: developing an equitable technology amidst a global pandemic

Season 1, Ep. 10

In this episode, I speak to Geoffrey Siwo about CRISPR and the challenges facing its development into a technique that can be applied equitably across the globe. Geoffrey talks about the importance of seizing the opportunity to influence the progress of the embryonic gene-editing technology for the better, before the data bias in genomic data and the disparity in researchers working on the technique leads to ingrained differences in the success of the application in different populations. The impact of the COVID-19 pandemic on this development is also exposed.

We also discuss Geoffrey's work, using CISPR in antiviral research to as a way of identifying small molecules capable of inducing broad-spectrum antiviral responses, with the potential to combat SARS-CoV-2.

Tune in to find out how Geoffrey believes we can develop CRISPR to be a truly equitable technology and to hear just how hopeful he is for the future of the technique.


The Talking Techniques podcast is hosted and produced by Tristan Free for BioTechniques. We would love to here more from our listeners about your opinions on the podcast, what you would like to hear more of and what you think we could do better!

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Twitter: @TristanFreefsg


More Episodes


Neuropixels: big data heaven or burying the lead in averages?

Season 4, Ep. 1
In this special episode of Talking techniques, one of two recorded at Neuroscience 2022, we speak to Tim Harris (Howard Hughes Medical Institute, VA, USA). Tim is the creator of Neuropixels, neural recording probes inserted into the brains of animal models, which allow researchers to collect signals from hundreds of individual neurons in different brain regions simultaneously over extended periods of time.Here, he shares the story behind his creation and details how they have changed the data collection landscape in Neuroscience. Tim also considers every inventor’s greatest concern: has his invention led to purely positive outcomes for the field? By enabling the collection of huge datasets have Neuropixels led to studies that bury findings in vast swathes of data or have they enabled researchers to collect enough information to discover the emphatic truth?Listen now to find out Tim’s opinions on these contentious debates in neuroscience and get key tips for utilizing neuropixels! Contents:Introduction: 00:00-03:00Tim's symposium on the capabilities of Neuropixels: 03:00-04.00Key takeaways from the symposium: 04:00-07:45The story of the development of neuropixels: 07:45-13:50Best practice tips for utilizing neuropixels: 13:50-15:15Challenges of utilizing neuropixels: 15:15-15:50Addressing the challenge of big data and sharing uncertainty: 15:50-17:30How neuropixels have accelerated neuroscience data generation: 17:30-19:30