Solving the Puzzle with Dr. Datis Kharrazian
Episode 19: The vagus nerve and gut health
In this video, Dr. Kharrazian explains how the vagus nerve affects digestion and other aspects of gut health, factors that can compromise vagus function, and the best ways to strengthen your vagus nerve . Not all vagal exercises are alike and you want to use the most effective ones. Dr. Kharrazian has worked with many patients over the years whose gut health was significantly compromised from poor vagal tone, particularly those impacted by brain injury.
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40. Episode 40: Hormone Balancing through Gut Health59:42In this episode, Dr. Kharrazian delves into the world of hormone imbalances, microbiome diversity, and the impact of polyphenols and phytoestrogens. He discusses evidence-based strategies for autoimmune disease, brain health issues, and chronic health conditions, and sheds light on the pivotal role of gut health in estrogen metabolism. He also addresses nutraceutical support for insulin resistance and regulating testosterone. For patient-oriented courses, visit https://drknews.com/online-courses/For CE and CME practitioner courses, visit https://kharrazianinstitute.com/00:00 Transitioning off HRT may benefit from modulators.06:05 Flavonoids affect estrogen receptor, 4 key foods.10:05 Healthy microbiome diversity enhances effectiveness of soy products.11:16 Carbs impact conversion of phytoestrogens efficiently.16:29 Gut health crucial for managing estrogen disorders.18:57 Diet, lifestyle, supplements affect microbiome diversity.20:53 Liver pathways detoxifying hormones, potential competition. Nutrients aid hepatic inflammation support.26:51 Essential fatty acids are critical for health.30:29 Prostate glands cause pelvic issues, need support.34:19 Men's testosterone, estrogen testing, insulin resistance, obesity, blood sugar imbalances, hypoglycemia, insulin resistance, dietary guidelines.36:02 Optimize diet to prevent blood sugar crashes.39:41 Review found herbal medicines improve PCOS symptoms.42:41 Aggressive protocol for PCOS using nutraceuticals.47:19 Nutraceuticals may protect serotonin cells, boost testosterone.50:44 Botanicals boost testosterone levels but may vary.53:42 Glial cells switch to pro-inflammatory state. Hormone changes amplify neuroinflammation.56:35 Peptides stimulate hormones, potential for endocrine treatment.58:37 Dr. Kharrazian's podcast and blog information.
39. Episode 39: Hormone Imbalance & Obesity01:29:43In this episode, Dr. Kharrazian provides insight into the impact of obesity on male and female hormone imbalances, infertility, and the body's endocrine system. From the role of adipose tissue to the effects of hormone replacement therapy, this episode explores the complexities of hormone balance and offers evidence-based strategies for managing these crucial aspects of health. Dr. Kharrazian discusses blood glucose management, gut health, and the impact of hormone deficiencies on mitochondrial function and other aspects of physiology.For patient-oriented courses, visit https://drknews.com/online-courses/For CE and CME practitioner courses, visit https://kharrazianinstitute.com/Learn more at drknews.comTimestamps:00:00 Hormones impact mitochondria, affecting cellular function.09:31 Mitochondrial health affects recovery and signaling pathways.12:00 Hormone replacement may fix mitochondrial dysfunction. Stress affects mitochondria.16:22 Certain genetic factors can increase health risks.25:26 Aromatization causes body fat increase, vicious cycle.31:00 Estrogen drop in women leads to fat tissue.32:52 Steroid use can disrupt endocrine system balance.42:35 Healthy adrenal function is crucial in perimenopause.48:03 Adrenal gland imbalances and stress responses summarized.53:04 Insulin resistance causes blood sugar roller coaster.57:10 Symptom patterns indicating early stages of insulin resistance.01:02:30 Gut bacteria convert chemicals and hormones.01:08:19 Hormone deficiency causes leaky gut, affecting health.01:12:26 Inflammatory diets cause low testosterone levels.01:20:18 Hormones critical for health and disease prevention.01:23:28 Hormone imbalances affect brain recovery and health.01:28:20 For more info visit drknews.com/podcast.
38. Episode 38: Hormone Imbalance and Environmental Toxins01:27:14In today's episode, we dive into the impact of hormone imbalance on overall health. From the critical role of adequate sleep in hormone regulation to the potential effects of environmental chemicals on endocrine function, Dr. Kharrazian shares valuable insights and evidence-based strategies for managing hormone imbalances.For patient-oriented courses, visit https://drknews.com/online-courses/For CE and CME practitioner courses, visit https://kharrazianinstitute.com/Learn more at drknews.com00:00 Toxic chemicals in everyday products, impacts on health.09:13 Endocrine disrupting chemicals impact female reproductive function.12:57 Endocrine disrupting chemicals impact PCOS in females.18:47 Endocrine disrupting chemicals impact serious health conditions.22:17 Inflammation impacts male testosterone and female infertility.32:18 Aquifers impact water supply with hormones, pharmaceuticals.34:54 Use multiple layers of water filtering systems.43:10 Air pollution impacts cortisol and microbiome health.48:26 Intense exercise is important for hormonal balance.52:57 Low or high body mass affects hormones.58:06 Injections are crucial for male obesity issues.01:03:36 Muscle mass affects health risks in obesity.01:08:32 Suppressed FSH, low TSH, hormone-related issues.01:12:27 Hormones, sleep, and strategies for better rest.01:19:50 Minimum needed protein is 1g/lb body weight.01:24:18 Blood sugar: Hypoglycemia vs insulin resistance management.
37. Episode 37: Personalized Strategies for Balancing Hormones01:23:13In this episode, we take a deep dive into the intricate world of hormone imbalances and hormone replacement therapy. Dr. Kharrazian discusses the latest research findings, revealing a clear linear dose-response relationship between oral contraceptive use and the risk of hypertension, as well as the links between hormone replacement therapy and various health concerns. We explore the complexities of hormone disorders and the need for a personalized approach to treatment, discussing the impact of hormones on clinical function, the liver, and the gut microbiome. Join us as we uncover the vital connection between hormones and overall health, as well as the challenges individuals face in receiving appropriate evaluation and treatment for hormone-related issues in the current healthcare system.Learn more at drknews.com00:00 Hormone disorders treated with diverse approaches.08:13 Hormone replacement therapies and over-the-counter options.14:10 Different types of hormonal contraceptives can cause weight gain and mood disorders.18:50 Glial cells produce main hormone for synaptic activity.25:45 Hormone replacement therapy not recommended for everyone.30:43 Testosterone therapy shows health benefits with low risk.37:49 Variety of lifestyle strategies for hormone balance.39:54 Viral infection may require immediate symptom management.48:43 Stimulating dysfunctional gland, hormones, pituitary issues, hormones.53:18 Protein pathways impact hormone levels causing symptoms.58:19 Androgel may not effectively metabolize into hormones.01:02:16 Microbiome dysbiosis consequences, particularly linked to hormones.01:08:23 Estradiol strongest, estrone not as strong.01:11:19 Urinary labs may not accurately test hormones.01:16:20 Maintain resiliency for hormone levels, health longevity.
36. Episode 36: How chronic systemic inflammation impacts the body and brain01:02:53In this talk, Dr. Kharrazian reviews the many pathways through which inflammation impacts the body. In a nutshell, inflammation is like throwing fuel onto the fire. Wherever you already have issues with pain or inflammation, an inflammatory diet and other triggers will simply worsen those conditions. Aging is another consideration — as we age we naturally become more prone to inflammation due to the gradual decline of the body's antioxidant systems. You will learn about these mechanisms, how to find triggers of inflammation, and anti-inflammatory and antioxidant strategies to mitigate the damage.Find out more on drknews.com.[00:00:24] . So now, when you're looking at what causes inflammation, the first answer is an imbalance of free radicals and antioxidants. Inflammation can also be caused by an imbalance of our microbiome. Systemic inflammation caused by imbalance of free radicals/antioxidants and microbiome.[00:23:37] Antioxidants and anti-inflammatories protect body from free radicals; various compounds have different mechanisms; common ones include vitamin E, fish oils, antihistamines, resveratrol, turmeric, vitamin A, vitamin C, and liposomal glutathione.[00:26:06] C reactive protein is a blood biomarker used as a general marker for inflammation. High levels (over 3 or 5) can indicate disease, but not all inflammation increases production of CRP.[00:30:21] Insulin resistance causes chronic inflammation, immune response, free radicals and oxidative stress, leading to tissue damage.[00:32:30] Exercise can cause inflammation in those with chronic conditions, so they should work their way up, clean their diet, and take antioxidants.[00:34:45] Neurogenic inflammation triggered by stress, lack of sleep and unhealthy relationships.[00:37:52] Turmeric has active curcuminoids that have an anti-inflammatory effect; people have different cost-benefit ratios for using it; other anti-inflammatory compounds may be more effective for some people.[00:43:36] Gut Puzzle program teaches diet, lifestyle, and understanding of gut dysfunctions to treat sibo and other conditions.[00:46:41] Cortisol has a bi-directional effect on inflammation, health, and gut; acute stress is anti-inflammatory, chronic stress is catabolic and can create inflammatory responses.[00:51:09] Gut motility problems, such as those caused by inflammation and neurodegenerative diseases, can lead to chronic constipation. Gut Health Puzzle program teaches how to address these issues.
35. Episode 35: Is it really SIBO?01:02:13The concept of small intestinal bacterial overgrowth is one that is becoming very popular but also widely misunderstood and confusing. Compared to the large intestine, there are very few bacterial species in the small intestine. When SIBO happens, the bacteria in the large intestine translocate to the small intestine causing fermentation, bloating, and excessive distension. Foods that commonly trigger SIBO symptoms include fibrous foods, sugar, sweeteners, prebiotics, and fermented foods.However, not all bloating and distension is SIBO. This is where confusion comes from. In this episode, I discuss how to tell it really is SIBO, SIBO tests, what causes it, and what to do about it.Find out more on drknews.com.
34. Episode 34: Brain problems cause gut problems01:03:04Chronic gut health problems some people face can stem from brain-related dysfunction. Key groups of brain-related problems can cause gut problems: neurodegeneration, traumatic brain injury, neurological autoimmunity, and neurodevelopment disorders.In this episode, I discuss these key categories of brain-related problems and how they affect the gut through the vagus nerve as one of its functions is activating the gastrointestinal tract. Find out more on our website at Drknews.com.
33. Episode 33: Glutathione: Your Most Important Defense01:02:11Glutathione is the body’s master antioxidant, meaning it helps protect your cells from pathogens such as viruses. It also lowers the risk of developing food and chemical sensitivities, and is a powerful ally in managing autoimmunity and preventing tissue destruction.Unfortunately, environmental toxins, chronic stress, unhealthy diets, inflammation, medications, alcohol, aging, and many other factors continually deplete glutathione. Making sure your glutathione status is strong and reducing glutathione depletion can play a profound role in immune resilience to viruses and in managing autoimmune disease, inflammation, chemical sensitivities, food sensitivities, and other chronic health issues.In this podcast, Dr Kharrazian discusses what glutathione really is, and the supplements and precursors that come in many different forms. How do you know which one to take? How much should you take? How can you tell it's working?Find out more on our website at Drknews.com
32. Episode 32: What thyroid lab tests really tell you21:56A complete thyroid panel can tell you about thyroid function, feedback loops, and how thyroid hormones are converting. The main thyroid markers are TSH, the pituitary hormone-stimulating gland, and T4 and T3, which are produced by the thyroid gland. Thyroid hormones are bound to proteins called thyroid hormone-binding globulins. Those are total T4 and total T3. T4 is converted to T3, which also makes reverse T3. At some point, thyroid-binding globulin levels release the T3 and T4, which then become free T3 and free T4. You can have defects all along these pathways, which I discuss in this podcast.To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.