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The Hormone That Could Reverse Kidney Disease | Thomas Weimbs, PhD
'High-protein diets hurt your kidneys!'. 'Once kidney disease starts, it only gets worse'. Heard something similar? It's just not the whole picture and also showing to be quite far from the truth.
Dr Thomas Weimbs, PhD is a Professor of Bioengineering at UCSB where his lab has spent over 20 years studying chronic kidney disease. What they found, mostly by accident like all great science, changed the course of their research entirely. From mouse models to human trials, they discovered that a state of nutritional ketosis could not only slow but potentially reverse the progression of kidney disease and all without drugs.
We cover:
š§ Why the real cause of most kidney disease is metabolic
š„© High-protein diets, carbs and the Barry Brenner myth
š§Ŗ The surprising effects of ketosis on kidney function
š§ Uric acid crystals and pH - the overlooked trigger
š¬ BHB (ketones) as hormones - and what they actually do
ā” Why no one makes money from metabolic health (and why that matters)
This episode is about kidneys, their function and dysfunction. But it's also about what happens when we follow the science, even when it contradicts the textbooks.
Mentioned in this episode:
- āWeimbs Labā on Facebook - patient-led community
Find Thomas Weimbs:
Santa Barbara Nutrients - KetoCitra
Weimbs Lab - UCSC
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88. Light, Cancer & Consciousness: Biology Through a New Lens | Dr Nirosha Murugan
52:59||Ep. 88Forget everything you thought you knew about biology. Dr Nirosha Murugan takes us way beyond molecules into the world of light, electricity and the energetic language of life itself. Here we explore a radical new lens on human health: one where energy, not just chemistry, drives disease, healing and even consciousness.From the role of light in cancer and red light therapy, to cells that 'think' without brains, to why homeostasis might be the wrong goal altogether. We cover:ā” Why biology might be better understood as patterns of energyš§ āThinkingā organisms that donāt have brainsš How light (even in the womb) shapes our biology𧬠Reframing cancer through the lens of energy resistanceš§āāļø Bioelectricity, metabolism & the limits of current scienceš Consciousness as emergent energy, not brain activityThis episode is a ride - part biology, part physics, part philosophy - and all energy.Find Nirosha:WebsiteX (Twitter)LinkedInMentioned in this episode:A New Science of Life by Rupert SheldrakeDemons in the Machine by Paul DaviesEnergy and Information in Art, Science, and TechnologyExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
87. Annie vs. Aging: Atomic Longevity Habits From The Longevity Leaderboard
55:35||Ep. 87𧬠What does it take to age slower than more than 99.9% of the population?Meet Annie who is currently ranked #2 in the Rejuvenation Olympics, measuring the slowest biological aging in the world (second only to Bryan Johnson). But Annieās not a billionaire with a team of scientists. Sheās a self-experimenting New Yorker who figured out what works for her and itās more simple (and more joyful) than youād think.In this episode, Ben and Annie explore her full protocol (yes, including a Kind Bar and red light therapy), the wild (and sometimes worrying) world of longevity culture and how the simplest shifts - walking more, laughing nightly, cutting alcohol - helped Annie feel better and slow her aging to 0.46x the typical rate.We cover:š§ Annie's supplement stack & skin protocolš„¦ How diet impacts pace of aging and why Annie is not anti-meatš§Ŗ Senolytics, grounding mats, liposomal vitamins & NOVOSš§Ø The supplement that lowered her skin age by 7 yearsš§āāļø Why overtraining raised her aging scoreš What didnāt work: PEMF, metformin & too much ājuiceāA refreshingly human conversation in a space that too often forgets what health really means.Find Annie:Instagram @annienoshMentioned in this episode:NOVOS CoreOura RingDunedinPACE Test via TrueDiagnosticsRejuvenation Olympics leaderboardAtomic Habits by James ClearExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
86. Why Drew Decker Believes Ketosis Could Change Mental Health Forever
30:18||Ep. 86Your brain runs on what you eat. So what happens when you fuel it with fat instead of sugar?Drew Decker and Ben join together to discuss his study on the ketogenic diet and depression in college students and how a simple dietary shift led to a 70% reduction in depression scores. No tracking apps, no dieticians, no hand-holding, just students with a budget, a plan, and a mission to feel better.Drewās journey started after a traumatic brain injury in the military and led him to Dr. Jeff Volekās lab, where heās now leading research into how ketosis may impact mental health, PTSD, inflammation, BDNF, energy metabolism and more.This is one of those episodes thatās equal parts hopeful, data-driven and deeply personal.š§ Ketosis as a tool for mental healthš The downside of keto? Pretty capped.š„ How college students stuck to keto on a tight budget𧬠BDNF, energy metabolism & brain inflammationš§ PTSD, trauma & the future of metabolic psychiatryš Exogenous vs endogenous ketonesš„© Animal-based, dairy-based, veggie-heavy ā what actually mattersš The ketogenic diet as metabolic medicineFind Drew:Instagram - @drew_d_deckerResearchGateMentioned in this episode:Keto-MojoFeasibility of Ketogenic Diet in College Students with Depression - A pilot studyExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
85. Why 'Eat Less, Move More' Doesnāt Work | Jessica Turton, PhD
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84. Muscles, Cancer & the Future of Exercise Medicine | Professor Mark Febbraio
01:08:12||Ep. 84What if your muscles could talk to your organs and maybe even prevent cancer? Here, Ben sits down with world-renowned exercise scientist Professor Mark Febbraio to dismantle the science behind myokines - molecules released by muscle that signal throughout the body.Insights covered in this episode:š§Ŗ Myokines and inter-organ communicationš¦ Exerciseās role in cancer prevention𧬠Inflammation, cytokines & what IL-6 doesš§ The cognitive power of exercise & BDNFšļøāāļø What type of training protects best and how much is too muchš Why we donāt understand GLP-1 side effects yetš§« The future of exercise mimetics & blood-based therapiesš§ Why āwe donāt knowā might be scienceās most honest answerFrom interleukin-6ās double life to how exercise blood can fight tumours, this oneās a digestible dive into how movement truly is medicine.Find Mark and papers reference in this episode:Google ScholarResearchGateExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
83. Weight Plateaus, GLP-1s & Why Keto Got So Complicated | Amy Berger, MS, CNS
01:01:26||Ep. 83Keto doesnāt have to be complicated. Yep, you heard that right.Nutritionist and author Amy Berger joins us to unpack the chaos of keto culture and how a once-simple metabolic switch has turned into a jungle of macros, misinformation and food fear. Amy cuts through the noise and brings keto back to what it was always meant to be: a simple, flexible, effective way of eating.Together with Ben, she covers the realities of weight loss stalls, hormonal shifts, fasting fads, the rise of ultra-processed keto products and what the science says about vegetables, carnivore diets, GLP-1s and calories.We cover:š„© Carnivore vs Keto - whatās happening metabolicallyš GLP-1s, weight loss drugs & long-term riskš Why weight loss might stall (and what to do about it)š§ Keto vs processed āketoā - marketing vs metabolismš„¬ In defense of vegetables (yes, really)š Fasting: myth, magic, or just misunderstood?Whether you're new to low-carb or neck-deep in macros and metabolic rabbit holes - this oneās for you.Find Amy:YouTubeWebsiteCoursesSubstackMentioned in this episode:The Alzheimerās Antidote by Amy BergerThe Stall Slayer by Amy Berger End Your Carb Confusion by Amy Berger & Dr. Eric Westman Dr. Eric Westman - Keto researcher & collaboratorThe Art and Science of Low Carbohydrate Living - Dr. Jeff Volek & Dr. Stephen PhinneyEat Like a Human - Dr. Bill SchindlerExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
82. Anorexia Recovery, Ketosis & How We Medicalised Hunger | Michelle Ann Hurn, RD
01:10:09||Ep. 82What if weāve been treating eating disorders the wrong way?In this deeply personal and provocative episode, registered dietitian Michelle Hurn shares her journey from severe anorexia and psychiatric medication to ultra-running and mental clarity through a radical change in nutrition.Ben and Michelle unpack the broken foundations of dietetics, why metabolic health is inseparable from mental health and how the standard of care may be making things worse.We cover:š„© Why animal-based diets are helping eating disorder recoveryš§ The link between stable blood sugar and psychiatric healthš The connection between calories, insulin and metabolic disordersšāāļø Running long distances with zero carb loadingš§Ŗ Exogenous ketones vs. yerba mate for ketone productionš„ GLP-1 drugs, health at every size and what weāre getting wrongFrom hospital feeding tubes to ketones and carnivore protocols, this is a raw, real and - we hope - hopeful conversation about what happens when you stop following the food pyramid and start listening to your body.Find Michelle:WebsiteInstagramX / TwitterMentioned in this episode:Book - The Dietitianās Dilemma by Michelle Ann HurnThe Fox Family Food FightCase Study: Ketogenic Diets in AnorexiaPaper - Therapeutic Carbohydrate RestrictionExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
81. āKetones Work - Even If We Donāt Know Whyā | Dr Adrian Soto-Mota, MD, PhD
01:08:53||Ep. 81Dr Adrian Soto-Mota, MD, PhD is one of the clearest and most curious voices in metabolic research and heās not afraid to say what doesnāt make sense anymore.Dr Adrian is an internal medicine physician and metabolic researcher based in Mexico City. In this conversation, we go deep on the limitations of RCTs, why calorie logic keeps breaking down, what lean mass hyper-responders teach us about lipids, and why sometimes the data works before we understand the mechanism.We also talk about the surprising impact of meat-heavy diets on IBD, why exogenous ketones matter more than people think and how metabolic dysfunction might be sitting at the core of psychiatric illness.This one is full of nuance and yet grounded in clinical reality.We cover:š§ The metabolic demands of the human brainš Why calories donāt predict fat gain the way we think𧬠Lean mass hyper-responders and cholesterol interpretationš Why nutritional RCTs canāt answer what we want them toš§Ŗ Hormones, definitions and broken language in medicineš§āāļø Metabolic psychiatry & the case for new mental health modelsFind Adrian:X profileGoogle scholarMentioned in this episode:Modeling Life by Alan GarfinkelBernoulliās Fallacy by Aubrey ClaytonRethinking Statistics by Richard McElreathHuman Metabolism by Keith Frayn & Rhys EvansJAMA Psychiatry paper on metabolic dysfunction & mental illnessExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer
80. The Dopamine Trap - Why We Keep Scrolling & How to Stop | Michael Long
01:04:38||Ep. 80š² Why do we keep chasing things that never quite satisfy?Weāre joined by The Molecule of More co-author Michael E. Long to unpack dopamine and why our brains are wired to want more, not to enjoy what we already have.From doomscrolling to dating apps, productivity obsessions to endless self-improvement, we explore how dopamine fuels craving and not contentment, and what we can do to stop living in the next and start living in the now. Michael shares insights from his new book, Taming the Molecule of More, and explains how understanding this one molecule could help us reclaim joy, focus, relationships, and maybe even our sanity.We cover:ā¤ļø Dopamine in dating, sex and long-term loveš Why chasing āmoreā always gives you lessšļø Behavioral addiction and craving cyclesš The difference between thinking about your life vs being in your lifeš Practical tools to tame the dopamine systemThis episode is for anyone interested in behavioural science, addiction, relationships or anyone who just wants to feel a little less hijacked by their phone.Find Michael:themoleculeofmore.comWebsiteBooks: The Molecule of MoreTaming the Molecule of MoreMentioned in this episode:A History of Western Philosophy by Bertrand RussellThe World According to Garp by John IrvingThe Braverman TestExploring the benefits of red and infra light therapy? Our community receive 10% off via this linkWant to watch this on video? Subscribe on YouTubeInstagram Ā @degreesofhealthDisclaimer