Pestpodden

Jørgen og Ingrid snakker seg gjennom tropesykdommen leishmaniasis - helt fra sandfluenes hemmelige liv, videre til diagnostikk og behandling. Vi får god hjelp av professor Bjørn Blomberg og doktor Zikre Gebremariam.

We meet Paul Garner (prof. emerit. and one of the founding fathers of Cochrane) and Rebecca Kuehn (Cochrane infectious diseases) for a talk about evidence-based medicine, critical appraisal and all things related to how we interpret and find the "truth" within research.Resources:1. Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2(8):e124.2. Garner P, Taylor-Robinson D, Sachdev HS. DEVTA: results from the biggest clinical trial ever. Lancet. 2013;381(9876):1439-41.3. Gigerenzer G. Making sense of health statistics. Bull World Health Organ. 2009;87(8):567.4.https://www.badscience.net/2010/07/yeah-well-you-can-prove-anything-with-science/5. de Souza DK, Thomas R, Bradley J, Leyrat C, Boakye DA, Okebe J. Ivermectin treatment in humans for reducing malaria transmission. Cochrane Database Syst Rev. 2021;6(6):CD013117.6. Foy BD, Alout H, Seaman JA, Rao S, Magalhaes T, Wade M, et al. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial. Lancet. 2019;393(10180):1517-26.7. Popp M, Reis S, Schiesser S, Hausinger RI, Stegemann M, Metzendorf MI, et al. Ivermectin for preventing and treating COVID-19. Cochrane Database Syst Rev. 2022;6(6):CD015017.8. Hadinegoro SR, Arredondo-Garcia JL, Capeding MR, Deseda C, Chotpitayasunondh T, Dietze R, et al. Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease. N Engl J Med. 2015;373(13):1195-206.9. Dans AL, Dans LF, Lansang MAD, Silvestre MAA, Guyatt GH. Controversy and debate on dengue vaccine series-paper 1: review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs. J Clin Epidemiol. 2018;95:137-9.10. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-94.11. https://bestpractice.bmj.com/info/toolkit/learn-ebm/what-is-grade/12.Guyatt G, Vist G, Falck-Ytter Y, Kunz R, Magrini N, Schunemann H. An emerging consensus on grading recommendations? ACP J Club. 2006;144(1):A8-9.

This is the "all-english"-version of the filaria-episode: Pestpodden presents a tropical topic that many of us struggle with understanding: filarial nematodes. Professor Mark Taylor - one of the worlds leading experts on filarial nematodes - guides us through this difficult topic - and presents some breaking research-news at the end of the episode.

Tropisk episode! Pestpodden snakker om filarioser med professor Mark Taylor - en av verdens ledende eksperter innen feltet. Dette er en faglig tung episode, men er du tropemedisinsk interessert og har lyst til å lære mer - så er dette episoden for deg! I tillegg presenteres noen "breaking news" fra forskningsverdenen mot slutten av episoden som du kan glede deg til.

Det multiresistente fremtidsscenarioet ble plutselig virkelighet. Kristian Tonby forteller om sitt møte med evakuerte krigsskadde pasienter fra Ukraina, og om hvordan vi kan håndtere multiresistente mikrober. Litteratur:Metodebok i infeksjonsmedisin, OUS: Infeksjoner med multiresistente bakterier (metodebok.no) Medevac: https://www.oslo-universitetssykehus.no/avdelinger/direktorens-stab/stab-medisin-helsefag-og-beredskap/medevac/

Norwegian:Vi intervjuer en av verdens fremste eksperter og forskere på antimikrobiell resistens: Adam Roberts fra Liverpool School of Tropical Medicine! Episoden finnes også i engelsk versjon.References/supplementary reading:1. Allel K, Day L, Hamilton A, Lin L, Furuya-Kanamori L, Moore CE, et al. Global antimicrobial-resistance drivers: an ecological country-level study at the human-animal interface. Lancet Planet Health. 2023;7(4):e291-e303.2. Roberts AP. Swab and Send: a citizen science, antibiotic discovery project. Future Sci OA. 2020;6(6):FSO477.3. AMR Review. https://amr-review.org/

In this first-ever english episode of Pestpodden, we are interviewing one of the worlds leading experts and researchers within the field of antimicrobial resistance; Adam Roberts from Liverpool School of Tropical Medicine. There is hope! References/supplementary reading:1. Allel K, Day L, Hamilton A, Lin L, Furuya-Kanamori L, Moore CE, et al. Global antimicrobial-resistance drivers: an ecological country-level study at the human-animal interface. Lancet Planet Health. 2023;7(4):e291-e303.2. Roberts AP. Swab and Send: a citizen science, antibiotic discovery project. Future Sci OA. 2020;6(6):FSO477.3. AMR Review. https://amr-review.org/

Synes du også resistens er vanskelig? Fatt mot og bli med oss i Pestpodden på en reise gjennom resistensen! I anledning Antibiotikauken 2023 har vi nemlig to spesialepisoder. I del èn får du en enkel intro til antimikrobiell resistens - mens i del to intervjuer vi en av verdens fremste eksperter og forskere på feltet; Adam Roberts. Gled deg!Referanser:1. Barlow M, Hall BG. Phylogenetic analysis shows that the OXA beta-lactamase genes have been on plasmids for millions of years. J Mol Evol. 2002;55(3):314-21.2. D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, et al. Antibiotic resistance is ancient. Nature. 2011;477(7365):457-61.3. Holmes AH, Moore LS, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016;387(10014):176-87.4. Woerther PL, Andremont A, Kantele A. Travel-acquired ESBL-producing Enterobacteriaceae: impact of colonization at individual and community level. J Travel Med. 2017;24(suppl_1):S29-s34.5. NORM/NORM-VET 2022. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway. Tromsø / Oslo 2023. ISSN:1502-2307 (print) / 1890-9965 (electronic). . 2022.7. https://atlas.ecdc.europa.eu/public/index.aspx?Dataset=27&HealthTopic=48. Antimicrobial Resistance C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-55.