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Munnhulen - tannroten til alt som er vondt?
Season 1, Ep. 9
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Ruben Dyrhovden er overlege og mikrobiolog som nylig har disputert. Vi snakker om funnene fra doktorgradsarbeidet hans, og munnhulens bakterier. Kanskje er tannhelse viktigere enn vi tror?
Referanser:
1. Gianos E, Jackson EA, Tejpal A, Aspry K, O'Keefe J, Aggarwal M, et al. Oral health and atherosclerotic cardiovascular disease: A review. Am J Prev Cardiol. 2021;7:100179.
2. Labeau SO, Van de Vyver K, Brusselaers N, Vogelaers D, Blot SI. Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis. 2011;11(11):845-54.
3. Fischer, L. A., Demerath, E., Bittner-Eddy, P. & Costalonga, M. Placental colonization with periodontal pathogens: the potential missing link. Am J Obstet Gynecol 221, 383-392 e3 (2019).
4. Blanc, V. et al. Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. Oral Dis 21, 905–912 (2015).
5. Han, Y. W. et al. Term Stillbirth Caused by Oral Fusobacterium nucleatum. Obstetrics Gynecol 115, 442–445 (2010).
6. Fardini, Y., Chung, P., Dumm, R., Joshi, N. & Han, Y. W. Transmission of Diverse Oral Bacteria to Murine Placenta: Evidence for the Oral Microbiome as a Potential Source of Intrauterine Infection▿ †. Infect Immun 78, 1789–1796 (2010).
7. Han, Y. W. et al. Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth. Infect Immun 72, 2272–2279 (2004).
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21:14||Season 1, Ep. 33Ebola er et høyaktuelt tema i disse dager med det pågående utbruddet i DR Kongo. For å gi litt mer bakgrunn gjør vi en historisk reise fra oppdagelsen av Ebola frem til i dag. Referanser:https://www.gov.uk/government/publications/ebola-overview-history-origins-and-transmission/ebola-overview-history-origins-and-transmission https://time.com/3548047/first-ebola-outbreak-history/ https://en.wikipedia.org/wiki/Kivu_Ebola_epidemichttps://en.wikipedia.org/wiki/Western_African_Ebola_epidemichttps://en.wikipedia.org/wiki/Ebolahttps://www.who.int/news-room/fact-sheets/detail/ebola-diseasehttps://journals.physiology.org/doi/full/10.1152/ajplung.00354.2014 https://www.sciencedirect.com/science/article/pii/S128645790500143732. ESCMID og vårmøtet 2026 - en liten (stor) reportasje
52:49||Season 1, Ep. 32Ingrid, Jørgen og Nikolai oppsummerer etter beste evne årets ESCMID (en av verdens største infeksjonsmedisinske konferanser) og vårmøtet (kanskje en av verdens minste infeksjonskonferanser) i denne reporasje-baserte episoden av Pestpodden.Referanser:1. White NM, et al. Effectiveness of oral care for the prevention of non-ventilator hospital-acquired pneumonia (HAPPEN): a multicentre, stepped-wedge, cluster-randomised trial in Australia. Lancet Infect Dis. 2026.2. Israelsen SB, et al. Short-course antibiotic therapy of 5 days in community-acquired pneumonia (CAP5): study protocol for a randomised controlled trial. BMJ Open. 2023;13:e069013. doi: 10.1136/bmjopen-2022-069013. 3. Chanderraj R, et al. Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime. JAMA Intern Med. 2024;184(7):769-77.4. Azevedo LCP, et al. Using the 2026 Surviving Sepsis Campaign Guidelines in Practice. Crit Care Sci. 2026;38:e20260036.5. Doumat G, et al. Short Versus Longer Antibiotic Duration for Community-Acquired Pneumonia : A Multicenter Target Trial Emulation. Ann Intern Med. 2026;179(5):629-36.6. Overdevest AG, et al. Antibiotic treatment for 1 day versus 4–7 days in patients with acute cholangitis after adequate endoscopic biliary drainage (COBRA): study protocol for a randomized controlled trial. Trials. 2026. doi: 10.1186/s13063-026-09524-7. PubMed: PMID 41689066. 7. Turner NA, et al. Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial. JAMA. 2025.8. Kristensen LH, et al. Diagnostic accuracy of dipsticks for urinary tract infections in acutely hospitalised patients: a prospective population-based observational cohort study. BMJ Evid Based Med. 2025;30(1):36-44.9. Giamarellos-Bourboulis EJ, et al. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. JAMA. 2026;335(9):775-86.31. Cryptococcus - diving further into the crypts of fungi
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39:25||Season 1, Ep. 29In today`s episode we speaking with Neil Stone, consultant in ID and microbiology, lead for mycology at University College Hospital London/Hospital for Tropical Diseases associate professor at University College London. We give you a "broad-spectrum"-dive into the fungus-field, including the latest news on Candida auris, strange names of new drugs and the other mysteries of mycology.28. Sopp! - med Klaus Høiland
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32:16||Season 1, Ep. 27Meslinger har vært en fryktet og hyppig forekommende sykdom opp gjennom historien. I moderne tid og med effektiv vaksine falt forekomsten – men i senere år har man sett stadig flere tilfeller (og utbrudd), inkludert i Europa og USA. Ingrid, Jørgen og Nikolai snakker seg gjennom meslinger «fra tidenes morgen» og frem til i dag. Bli med på reisen!Og - for infeksjonsmedisinsk helsepersonell som lytter til episoden våren 2025 - her er lenke til påmelding NSCMID: Home - NSCMID 2025.Referanser:1. Roald Dahl, 1986: “Measles: A dangerous disease” (open letter to parents).2. Hübschen JM, et al. Measles. Lancet. 2022;399(10325):678-90.3. Berche P. History of measles. Presse Med. 2022;51(3):104149.4. Petrova VN, et al. Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles. Sci Immunol. 2019;4(41).5. Mina MJ, et al. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science. 2019;366(6465):599-606.6. Belongia EA, Naleway AL. Smallpox vaccine: the good, the bad, and the ugly. Clin Med Res. 2003;1(2):87-92.8. Madsen KM, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002;347(19):1477-82.10.Holzmann H, et al. Eradication of measles: remaining challenges. Med Microbiol Immunol. 2016;205(3):201-8.11.Jafri SK, et al. Subacute sclerosing panencephalitis - current perspectives. Pediatric Health Med Ther. 2018;9:67-71.12. de Swart RL, et al. Rinderpest eradication: lessons for measles eradication? Curr Opin Virol. 2012;2(3):330-4.13.Kim TH, et al. Vaccine herd effect. Scand J Infect Dis. 2011;43(9):683-9.14.Doll MK, Correira JW. Revisiting the 2014-15 Disneyland measles outbreak and its influence on pediatric vaccinations. Hum Vaccin Immunother. 2021;17(11):4210-5.13.Nuwarda RF, et al. Vaccine Hesitancy: Contemporary Issues and Historical Background. Vaccines (Basel). 2022;10(10).16.Minta AA, Ferrari M, Antoni S, et al. Progress Toward Measles Elimination — Worldwide, 2000–2023. MMWR Morb Mortal Wkly Rep 2024;73:1036–1042.17.State School Immunization Requirements and Vaccine Exemption Laws, CDC 2022,State School Immunization Requirements and Vaccine Exemption Laws18.Epidemiologi meslinger UK og Europa: https://www.gov.uk/government/publications/measles-epidemiology-2023, European Region reports highest number of measles cases in more than 25 years – UNICEF, WHO/Europe26. Tyfus, Napoleon og Emil i Lønneberget
30:12||Season 1, Ep. 26Tyfus har satt sitt preg på både litteratur og historie - og Europakartet kunne kanskje sett annerledes ut var det ikke for denne vektorbårne bakterien.Jørgen, Nikolai og Ingrid drar på reise igjen, denne gang for å finne ut av mer om tyfus om dens slektninger, rickettsiosene.Referanser:1) Pesapane F et al. Hieronymi Fracastorii: the Italian scientist who described the "French disease". An Bras Dermatol. 2015 Sep-Oct;90(5):684-6. doi: 10.1590/abd1806-4841.20154262. PMID: 26560214; PMCID: PMC4631234.2) Peterson, R. K. D. 1995. Insects,disease, and military history: the Napoleonic campaigns and historical perception. American Entomologist. 41:147-160. 3) Angelakis E et al. The History of Epidemic Typhus. Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.PoH-0010-2015. PMID: 27726780.4) Larry Lutwick. Brill-Zinsser disease. The Lancet, Volume 357, Issue 9263, 2001, Pages 1198-1200, ISSN 0140-6736, https://doi.org/10.1016/S0140-6736(00)04339-7.(https://www.sciencedirect.com/science/article/pii/S0140673600043397)5) Weiss E, Strauss BS. The life and career of Howard Taylor Ricketts. Rev Infect Dis. 1991 Nov-Dec;13(6):1241-2. doi: 10.1093/clinids/13.6.1241. PMID: 1775858.6) Walker DH. Ricketts creates rickettsiology, the study of vector-borne obligately intracellular bacteria. J Infect Dis. 2004 Mar 1;189(5):938-55. doi: 10.1086/381710. PMID: 14976612. Ricketts Creates 7) Jan Brøgger sr. Epidemier. En natur-og kulturhistorie. Damm forlag. 2020.8) Emelyanov VV. Evolutionary relationship of Rickettsiae and mitochondria. FEBS Lett. 2001 Jul 13;501(1):11-8. doi: 10.1016/s0014-5793(01)02618-7. PMID: 11457448.9) Mørch K et al. Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy. BMC Infect Dis. 2017 Oct 4;17(1):665. doi: 10.1186/s12879-017-2764-3. PMID: 28978319; PMCID: PMC5628453.10) Raoult D et al. Outbreak of epidemic typhus associated with trench fever in Burundi. Lancet. 1998 Aug 1;352(9125):353-8. doi: 10.1016/s0140-6736(97)12433-3. PMID: 9717922.11) Didier Raoult et al. Evidence for Louse-Transmitted Diseases in Soldiers of Napoleon’s Grand Army in Vilnius, The Journal of Infectious Diseases, Volume 193, Issue 1, 1 January 2006, Pages 112–120.12) Varghese GM et al. INTREST Trial Investigators. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. N Engl J Med. 2023 Mar 2;388(9):792-803. doi: 10.1056/NEJMoa2208449. PMID: 36856615; PMCID: PMC7614458.