New Hemp Times

Hello my fellow Hemp nuts! Are you ready for the cannabis bonanza?! Welcome to the New Hemp Times show recorded at Gotham Studio, the sweetest smelling podcast studio in the world. Thank you to our Patreon supporters!

We have a fun show for you today! Joining us is Greer Barnes, Randy Cameron jr., Jan Roberts, CSW, and Jahan Marcu, Ph.D.

New Hemp Times Segments:

• Our word of the day is manonmana

• Research Focus/High Science: Dispensary Training

• Listener Call in Q and A

• CannaBusting - Finding or Fiction We will test your knowledge of recent cannabis news and science

• FDA Hearing on May 31st

• Mind Munchies

WORD OF THE DAY: Manonmana an ancient word for cannabis, meaning “accomplishes the objects of the mind”

RESEARCH FINDINGS

Today’s research focus is on a study that is bigger than gravitational waves; We will discuss a recent study on dispensary staff training.

Buller, D. B., Woodall, W. G., Saltz, R., Grayson, A., & Buller, M. K. (2019). Implementation and Effectiveness of an Online Responsible Vendor Training Program for Recreational Marijuana Stores in Colorado, Oregon, and Washington State. Journal of Public Health Management and Practice : JPHMP, 25(3), 238–244. http://doi.org/10.1097/PHH.0000000000000843

CANNABUSTING:

When you hear something strange about marijauna…who you gonna call?!

Below are our sources from discussing findings and fictions from recent news and science (partially sourced from MJToday):

(NAT)

Marijuana

Stocks Took a Hit Because There's Too Much 'Sub-par Quality' Pot | Barron's

(NAT)

Mitch

McConnell Floats Legislation To Resolve 'Glitches' In Hemp Regulation | Marijuana

Moment

(NAT)

Weed's

Biggest Investors Are Alcohol and Tobacco Companies | Merry Jane

(MI)

University

of Michigan Police: No arrests made during Hash Bash 2019 | Click on Detroit

(NY)

Pot

Tests On Parolees Could Soon Become History In NYC | WCBS News Radio 880

(INT)

Chile

Brings up full scale marijuana decriminalization, again | Pot Network

(INT)

More

Parents Are Being Forced to Smuggle Medical Marijuana into the UK | Civilized

(INT)

UK

Cops Will Stop Arresting People for Weed | Merry Jane

(INT)

UK

Customs Took $6,000 Worth of Medical Cannabis from an Epileptic Girl's Mother

| Merry Jane

(NAT)

FDA

commissioner who approved first drug containing cannabis steps down | News 5

Cleveland

(NAT)

Smoke Up and Drive for Science- Volunteers Needed | Leafly

Liquid

marijuana use on surge in South Korea

CBD

hype: Is this hemp-plant derivative snake oil or a legit remedy?

https://www.usatoday.com/story/news/health/2019/04/08/cbd-marketers-cannabidiol-claim-hemp-derived-product-works/3374793002/

CBD

and THC-A oil dispensaries set to open across Virginia

(NAT)

Notorious BIG's Son Launches Weed Brand in His Father’s Name | Merry Jane

SCIENCE CANNABUSTING

Researchers concluded in a recent study, “Though it is unclear why, the risk of dependence formation among heavy marijuana users appear to have declined since 2002.” “One might have expected the population prevalence of marijuana dependence to have increased proportionally to the substantial increase in prevalence of marijuana use. That this did not occur presents a puzzle…” Davenport, S. (2018). Falling rates of marijuana dependence among heavy users. Drug and Alcohol Dependence, 191, 52–55.

http://doi.org/10.1016/j.drugalcdep.2018.06.025

NEXT

The Surprising Reach of FDA Regulation of Cannabis, Even After Descheduling.

O'Connor SM, et al. Am Univ Law Rev. 2019.

University of Washington School of Law.

University of Missouri School of Law.

CitationAm Univ Law Rev. 2019;68(3):823-925.

Cannabis producers appear to assume that descheduling would facilitate a robust market in cannabis-based edibles and dietary supplements. In fact, neither of these things is true. If cannabis were descheduled, the FDA's complex and comprehensive regulatory framework governing foods, drugs, and dietary supplements would preclude much of this anticipated commerce. For example, any medical claims about cannabis would require the seller to complete the rigorous new drug approval process, the cost of which will be prohibitive for most current traditional providers.

NEXT

Science/Human: Cannabis use is associated with a lower probability of obesity in healthy people

In a representative group for the US population, who were followed for 3 years cannabis use was associated with a lower increase of BMI (body mass index). Researchers of the Department of Family Medicine of Michigan State University in East Lansing, USA, published their research in the International Journal of Epidemiology. Adults completed computer-assisted personal interviews on cannabis use, body weight and height at Waves 1 (2001-2002) and 2 (2004-2005).

At wave 2, 77% of the participants never used cannabis, 18% had discontinued use, 3% were initiates and 2% were persistent users. Estimated BMI change over 3 years shows an increase for all subgroups. Compared with never-users, there was an inverse association of cannabis use with obesity and body mass index.

NEXT

Science: Degradation of THC over a course of 4 years under different storage conditions

Researchers of the Laboratory of Environmental Hygiene and Forensic Toxicology of the DMPO Department in Venice, Italy, investigated the degradation of THC in herbal and resin materials containing different initial concentrations of THC. Four representative samples were collected from each study material and were maintained for a prolonged time (four years) under different controlled storage conditions: (A) light and room temperature (22°C); (B) darkness and room temperature; (C) darkness and refrigeration (4 °C); (D) darkness and freezing (-20 °C)

Almost 100% of THC was degraded after four years under conditions A and B (room temperature, light or dark). Data indicated that the storage temperature and light exposure had two different effects on the conversion of THC to CBN. Models were proposed which allow to predict the storage time, if unknown, and the initial content of THC, from the measurement of THC and CBN content at any time under storage condition A.

Zamengo L, Bettin C, Badocco D, Di Marco V, Miolo G, Frison G. The role of time and storage conditions on the composition of hashish and marijuana samples: A four-year study. Forensic Sci Int. 2019;298:131-137.

NEXT

Science/Human: Cannabis use in adolescents decreased in Washington State after legalisation

Cannabis use decreased among adolescents according to a survey with 76,000 youth representative of 8th and 10th grades in the state of Washington. It only increased among 12th-grade working youth.

College of Nursing-Spokane, Washington State University, Washington, USA.

Graves JM, et al. J Adolesc Health. 2019 Mar 14. [in press]

Science/Human: Cannabis use mitigates inflammation associated with alcohol use

In a study with 66 regular alcohol drinkers concomitant cannabis use reduced the concentration of the pro-inflammatory mediator interleukin-6. Authors wrote that there “preliminary findings suggest that cannabinoid compounds may serve to mitigate inflammation associated with alcohol use.” Department of Psychology & Neuroscience, University of Colorado Boulder, Colorado, USA. Karoly HC, et al. Alcohol Clin Exp Res. 2018;42(3):531-539.

Science/Human: Heavy cannabis use is more likely associated with depression

According to a large study “cannabis users have consistently higher prevalence rates of depressive disorders compared with nonusers.”

Department of Medicine and Surgery, University of Milano Bicocca, Italy. Carrà G, et al. Subst Abus. 2019:1-7.

Science/Human: Cannabis use in patients with schizophrenia is associated with a reduced risk for inflammatory bowel disease

In a study with 21,066 cases with schizophrenia and 176,935 control subjects cannabis use was associated with a reduced risk for inflammatory bowel disease in patients with schizophrenia but not in the control group. Copenhagen Research Center for Mental Health - CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Olesen JA, et al. Psychol Med. 2019:1-8.

Science/Human: CBD degradation is slower in people with hepatic impairment

In a clinical study patients with liver disease presented with slower degradation of CBD than in healthy people. Authors concluded that their “findings indicate that dose modification is necessary in patients with moderate and severe hepatic impairment, and a lower starting

dose and slower titration are necessary based on benefit-risk.” GW Research Ltd, Cambridge, UK Taylor L, et al. J Clin Pharmacol. 2019 Mar 28. [in press]

Science/Human: Cannabis use during pregnancy is associated with lower birth weight

In a study with 2173 patients infants born to mothers, who tested positive for THC in urine had a lower birth weight (mean: 2925 g) than babies not exposed to THC (mean: 3235 g). Department of Obstetrics and Gynecology and Hatton Research Institute, TriHealth, Cincinnati, Ohio, USA. Howard DS, et al. J Addict Med. 2019 Mar 1. [in press]

Science/Animal: The CB2 receptor is involved in wound healing of the cornea

In a study with mice researchers found evidence that the CB2 receptor plays an important role in healing after injury of the cornea and that these receptors are required for the normal course of wound closure.

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA. Murataeva N, et al. Exp Eye Res. 2019 Mar 21. [in press]

Science: New patents for about 30 new cannabinoid receptor antagonists between 2015 and 2018

According to a review on new patents “peripherally acting CB1 receptor antagonists and modulators are an emerging class of drugs for metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other important disorders where this receptor has been implicated.”

Center for Drug Discovery, RTI International, Research Triangle Park, USA. Amato G, et al. Expert Opin Ther Pat. 2019 Mar 20. [in press]