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Coronapod: 'viral ghosts' support idea that SARS-CoV-2 reservoirs could be behind long COVID
Millions of people around the world have been left managing the complex and amorphous syndrome that is long COVID. But the underlying cause of this myriad of symptoms is not clear. One hypothesis is that the virus is able to find a safe haven in the body from which it can bide its time and potentially re-emerge - a viral reservoir. Now researchers studying long COVID have found evidence of SARS-CoV-2 in a series of organs around the body, most notably the gut, months after the infection appears to have been cleared from the respiratory system. While there is still a long way to go before the reservoir hypothesis can be confirmed, these data provide compelling new support for the theory. In this episode of Coronapod, we discuss how the studies were carried out, why the question of long COVID's cause is so difficult to crack, and what more needs to be done to get a firm answer.
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The Nature Podcast festive spectacular 2025
42:16|00:46 The gifts that sparked a love of scienceNature put a call out for readers to tell us about memorable presents that first got them interested in science, or mementos of their life in research. These include telescopes, yeast-themed wedding rings, and... cows’ eyes.Nature: The gift that shaped my career in science08:12 “I am the Very Model of a Miniature Tyrannosaur”In the first of our annual festive songs celebrating the science of the past year, we tell the story of a diminutive dinosaur that turned out to be its own species.Nature Podcast: Meet the ‘Wee-rex’. Tiny tyrannosaur is its own speciesNature Video: Hotly debated dinosaur is not a tiny T. rex after all11:43 A very scientific quizAn all-star cast competes for the glory or being the winner of the Nature Podcast’s 2025 festive quiz.Nature: Meet the ‘Wee-rex’. Tiny tyrannosaur is its own speciesNature: This company claimed to ‘de-extinct’ dire wolves. Then the fighting startedNature Podcast: 3D-printed fake wasps help explain bad animal mimicryNature Video: ‘Aqua tweezers’ manipulate particles with water wavesNature Podcast: Sapphire anvils squeeze metals atomically-thinNature Video: Vesuvius volcano turned this brain to glassNature Podcast: Ancient viral DNA helps human embryos developNature Video: Magnetic fibres give this robot a soft gripNature: These contact lenses give people infrared vision — even with their eyes shutNature Video: Is this really the world's largest mirror? Researchers put it to the testNature Podcast: World’s tiniest pacemaker could revolutionize heart surgeryNature Podcast: Earth’s deepest ecosystem discovered six miles below the seaNature Podcast: Nature goes inside the world’s largest ‘mosquito factory’ — here’s the buzzNature Podcast: Apocalypse then: how cataclysms shaped human societiesNature Podcast: Honey, I ate the kids: how hunger and hormones make mice aggressive25:21 “Hard the Hydrogel is Stuck”Our second festive song is an ode to a rubber duck that was stuck to a rock, thanks to a newly designed, super-adhesive hydrogel.Nature Podcast: Underwater glue shows its sticking power in rubber duck testNature Video: Why did researchers stick a duck to a rock? To show off their super glue28:42 Nature’s 10Each year, Nature’s 10 highlights some of the people who have helped shape science over the past 12 months. We hear about a few of the people who made the 2025 list, including: a civil servant who stood up for evidence-based public-health policy; the science sleuth who revealed a retraction crisis at Indian universities; and the baby whose life was saved by the first personalized CRISPR therapy.Nature: Nature’s 10Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
Neanderthals mastered fire — 400,000 years ago
22:32|00:46 Evidence of the earliest fire Baked soil, ancient tools, and materials that could be used to start fires show that Neanderthals were making fire in the UK 400,000 years ago — the earliest evidence of this skill found so far. Ancient humans are known to have used naturally occurring fires, but evidence of deliberate fire-starting has been hard to come by. A new suite of evidence pushes back the date of fire mastery by 350,000 years. The team behind the finding believe it helps create a more nuanced picture of Neanderthals, who perhaps gathered round fires and told stories in ancient Europe. Research Article: Davis et al.News and Views: Oldest known evidence of the controlled ignition of fire11:31 Research HighlightsMachine-learning algorithms can help to identify traces of life in ancient rocks — plus, why paintings containing a vivid green pigment lose their lustre over time. Research Highlight: AI finds signs of life in ancient rocksResearch Highlight: The mystery of emerald green — cracked13:55 How AI chatbots can sway voters with ease Research suggests that artificial-intelligence chatbots can influence voters’ political views and have a bigger effect than conventional campaigning and advertising. One study found that chatbot conversations swung participants’ candidate preferences by up to 15 percentage points, while another revealed that the chatbots’ effectiveness stems from their ability to synthesize a lot of information in a conversational way. Nature: AI chatbots can sway voters with remarkable ease — is it time to worry?
Photobombing satellites could ruin the night sky for space telescopes
23:06|00:46 How satellite mega-constellations could ruin space-based astronomyThe ability of space-based telescopes to image the distant Universe could be in peril, according to new research investigating the impacts of light-pollution from future satellites. Streaks of reflected light from satellites currently in low-Earth orbit are already seen in telescope images, and planned launches could raise the number of satellites from around 15,000 to over half-a-million. Computer modelling revealed that this drastic increase would result in images taken by instruments like the Hubble Space Telescope becoming unusable by astronomers. The team propose a series of strategies to help mitigate these impacts, preventing this future becoming reality.Research Article: Borlaff et al.Nature: Satellite swarms set to photobomb more than 95% of some telescopes’ images11:08 Research HighlightsHow researchers have sped up the trapping of antimatter atoms — plus, how hydrogen fuel emission benefits vary considerably from sector to sector.Research Highlight: Laser cooling traps more antimatter atoms than ever beforeResearch Highlight: Hydrogen fuel isn’t always the green choice13:41 The negative consequences of video call glitchesGlitches in video calls are an annoying feature of everyday life, but these brief interruptions could have serious real-world impacts, according to analysis from a team of researchers. In one experiment, the team found that video calls with glitches decreased the likelihood of someone being hired for a job. Analysis of other data suggested glitchy calls were associated with lower chances of individuals being granted parole. The team behind the work think that these visual errors break the illusion that a video call is a real face-to-face conversation, potentially impairing judgements about the quality of the information discussed.Research article: Brucks et al.Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
Audio long read: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier
17:19|CRISPR-based gene editing has revolutionized modern biology, but these tools are unable to access the DNA that resides inside mitochondria. Researchers are eager to access and edit this DNA to understand more about the energy production and the mutations that can cause incurable mitochondrial diseases.Because CRISPR can’t help with these problems, researchers have been looking for other ways to precisely edit the mitochrondrial genome. And the past few years have brought some success — if researchers can make editing safe and accurate enough, it could eventually be used to treat, and even cure, these genetic conditions.This is an audio version of our Feature: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier
This is what lightning on Mars sounds like
28:24|00:46 Martian ‘micro-lightning’The sounds of ‘micro-lightning’ have been recorded by NASA’s Perseverance rover, ending a long search for the phenomenon on Mars. A lack of suitable equipment has made it difficult to gather evidence of lightning on the red planet, but a team of researchers realized that a microphone on Perseverance should be able to pick up the characteristic sounds of electrical discharges. In total they found 55 such examples, along with signs of electrostatic interference indicative of the phenomenon. They dubbed the electric bursts ‘micro-lightning’, as they are far smaller than the lighting seen on Earth, due to the thin Martian atmosphere. The team believe this finding could help better understand Martian chemistry and how best to design equipment to explore the planet’s surface.Research Article: Chide et al.News and Views: Is there lightning on Mars?11:03 Research HighlightsHow the biology of male seahorses’ brood pouches appears similar to mammalian pregnancy— plus, why Neanderthals’ jaws were so beefy.Research Highlight: The origin of male seahorses’ brood pouchResearch Highlight: Neanderthal DNA reveals how human faces form13:36 The key takeaways from COP30The UN’s climate conference, COP30, came to a close last week in Brazil. Nature reporter Jeff Tollefson tells us what was and wasn’t agreed during the final negotiations.Nature: What happened at COP30? 4 science take-homes from the climate summit22:27 Why women may retract less than menA new analysis suggests that female authors retract fewer medical science papers than their male counterparts. Women are known to be underrepresented in the medical sciences, but even accounting for this an AI-tool revealed that female authors featured on far fewer retracted research articles. Reporter Jenna Ahart has been investigating and told us why this might be, and what it means for research more broadly.Nature: Women seem to retract fewer papers than men — but why?Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
Insulin cream offers needle-free option for diabetes
42:05|00:45 A molecule that delivers insulin through the skinResearchers have developed a skin-permeable polymer that can deliver insulin into the body, which they say could one day offer an alternative to injections for diabetes management. The skin’s structure presents a formidable barrier to the delivery of large drugs but in this work a team show that their polymer can penetrate though the different layers without causing damage. Insulin attached to this polymer was able to reduce blood glucose levels in animal models for diabetes at a comparable speed to injected insulin. While further research is required on the long-term safety of this strategy, the team hope it could offer a way to non-invasively deliver other large-molecule drugs into the body.Research Article: Wei et al.09:23 Research HighlightsHow extreme drought may be humanity’s biggest challenge after a huge volcanic eruption — plus, turning a bacterium into a factory for a colour-changing pigmentResearch Highlight: Volcano mega-eruptions lead to parched timesResearch Highlight: Dye or die: bacterium forced to make pigment to stay alive11:42 How language lights up the brain, whatever the tongueThe human brain responds in a similar way to both familiar and unfamiliar languages, but there are some key differences, according to new research — a finding that may explain why learning a language can be difficult. A study looking involving 34 people showed that listening to an unfamiliar language triggers similar neural activity to listening to their native tongue. The finding implies that human speech triggers a common reaction in the brain regardless of understanding. However, there were subtle differences when listening to a known language that may help explain how people actually understand words.Research Article: Bhaya-Grossman et al.Neuron: Zhang et alSounds used under CC BY 4.027:18 Briefing ChatSigns that greenhouse-gas emissions may peak around 2030 — plus, evidence of dog breeding by ancient humans.Nature: Global greenhouse-gas emissions are still rising: when will they peak?Nature: How ancient humans bred and traded the first domestic dogsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
‘Malicious use is already happening’: machine-learning pioneer on making AI safer
15:06|Yoshua Bengio, considered by many to be one of the godfathers of AI, has long been at the forefront of machine-learning research . However, his opinions on the technology have shifted in recent years — he joins us to talk about ways to address the risks posed by AI, and his efforts to develop an AI with safety built in from the start. Nature: ‘It keeps me awake at night’: machine-learning pioneer on AI’s threat to humanity
Huge eruption on a distant star confirmed at last
33:51|00:45 A coronal mass ejection from a distant starResearchers have detected what they say is the strongest evidence yet of a coronal mass ejection (CME) coming from a star other than our Sun. CMEs are massive bursts of fast-moving plasma that can be detected thanks to the characteristic radio signal they produce. However, despite decades of searching, these signals have only been identified from the Sun. Now a team has identified a similar signal coming from a distant star in the Milky Way. They hope their discovery will lead to better understanding of the impact these colossal events might have on the atmospheres of exoplanets, and their chances of being habitable.Research Article: Callingham et al.12:28 Research HighlightsVideo footage of a devastating earthquake provides a first-of-its-kind glimpse of a dramatic ground rupture — plus, a flock of comets seen outside our Solar System.Research Highlight: Single video camera tells the story of deadly Myanmar quakeResearch Highlight: A host of ‘exocomets’ swarms a distant star14:29 The rare genetic variants that may increase the risk of ADHDAttention-deficit/Hyperactivity disorder (ADHD) is a condition that affects around 1 in 20 young people, but its underlying causes are not fully understood. Now, a team of researchers show that three rare genetic variants are implicated in an increased risk of ADHD, which may play a role in the neurons involved in dopamine signalling. While this work provides a better understanding of the complex genetics at play, the authors caution more research is needed to unpick the complex interplay other factors involved in ADHD.Research Article: Demontis et al.18:41 Briefing ChatA high-resolution digital map for Roman roads, and how speaking more than one language could slow brain ageing.Nature: ‘Google Maps’ for Roman roads reveals vast extent of ancient networkNature: Want a younger brain? Learn another languageSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
Meet the ‘Wee-rex’. Tiny tyrannosaur is its own species
28:48|00:45 The debate around NanotyrannusA hotly debated species of dinosaur, assumed by many to be a juvenile T. rex, is actually a separate species, according to new research. Nanotyrannus was a dinosaur anatomically similar to T. rex, but about a tenth of the size, leading many to argue it was a young version of the iconic species. However, examination of the limb bones of a well-preserved Nanotyrannus fossil suggests it was close to finishing its growth and so would never become as large as a T. rex, leading the authors to argue that it is, in fact, a different species.Research Article: Zanno and NapoliNews and Views: T. rex debate settled: contested fossils are smaller rival species, not juvenilesNews: ‘Teenage T. rex’ fossil is actually a different speciesVideo: Hotly debated dinosaur is not a tiny T. rex after all08:46 Research HighlightsAn artificial ‘neuron’ could pave the way to build a brain-inspired computer — plus, how bats buck the trend by hunting prey their own size.Research Highlight: Artificial brains with less drainResearch Highlight: By the time you hear these bats, it’s too late11:19 A less invasive way to prevent breast cancerAn ‘anti-hormone’ therapy has shown promise in halting the onset of hallmarks associated with breast cancer, in a small trial. Breast cancer is a leading cause of death in women worldwide, but preventative measures, such as mastectomies, are invasive. A new study examined the efficacy of a treatment that blocks progesterone, a hormone thought to play an important role in breast cancer progression. The therapy reduced both specific clinical markers of breast cancer and the number of cells that can become cancerous. Larger, longer trials are needed to show that this treatment could ultimately become part of a breast cancer prevention strategy, but the team think that this work shows the promise of this approach.Research Article: Simões et al.18:41 Briefing ChatA new approach to speed up CRIPSR therapies reaching clinical trials, and how vocal cords could be healed using a tiny 3D printer.Nature: Personalized gene editing helped one baby: can it be rolled out widely?Nature: World’s smallest 3D bioprinter could rebuild tissue during surgerySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.