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Coronapod: the open-science plan to unseat big Pharma and tackle vaccine inequity
Inequity has been a central feature of the COVID19 pandemic. From health outcomes to access to vaccines, COVID has pushed long-standing disparities out of the shadows and into the public eye and many of these problems are global. In this episode of Coronapod we dig into a radical new collaboration of 15 countries - co-led by the WHO, and modelled on open-science. The project, called the mRNA vaccine technology transfer hub, aims to create independent vaccine hubs that could supply the global south, and take on the giants of the pharmaceutical industry in the process. But the road ahead is long - the challenges are complex and numerous, and the odds are stacked against them. But at a time when stakes couldn't be higher, momentum is building and if successful, the tantalising possibility of an end to a dangerous legacy of dependence looms. Can it be done? And if so, what needs to change to make it happen? We ask these questions and more.
News Feature: The radical plan for vaccine equity
This project was supported by the Pulitzer Center.
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AI, bounties and culture change, how scientists are taking on errors
49:19|A simple methodological error meant that for years researchers considered drinking moderate amounts of alcohol to be healthy. Now plenty of evidence suggests that isn't the case, but errors like this still plague the scientific literature. So, how can the scientific literature become more error-free?In the first episode of this two-part series, to determine what steps can be taken to help clean up science we explore peer review, replications, AI and even paying people to detect errors.This episode was written and produced by Nick Petrić Howe. Dan Fox was the editor. The Swiss horn music came from DangerLaef on Freesound. All other sound effects and music were provided by Triple Scoop Music.Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.‘Stealth flippers’ helped this extinct mega-predator stalk its prey
32:50|In this episode:00:48 The ancient mega-predator with a ‘stealth mode’The extinct marine mega-predator Temnodontosaurus had specialised adaptations to stealthily hunt its prey, suggests an analysis of a fossil flipper. Although Temnodontosaurus was a member of a well-studied group of marine reptiles called ichthyosaurs, its lifestyle has been a mystery due to a lack of preserved soft tissue. Now, a team have studied the fossil remains of a fore-fin, revealing several anatomical details that likely reduced low-frequency noise as the animal swam. It’s thought that these adaptations helped Temnodontosaurus stalk other ichthyosaurs and squid-like creatures that made up its prey.Research Article: Lindgren et al.09:46 Research HighlightsResearch shows that future space probes could navigate using two stars as reference points, and how objects are more memorable when people encounter them while feeling positive emotions.Research Highlight: Lonely spacecraft can navigate the starsResearch Highlight: Memory gets a boost from positive emotion12:11 ‘Leaky’ mitochondria could be the root cause of sleepCumulative damage to mitochondria during waking hours could be a key driver for the need to sleep, according to new research. In fruit fly experiments, a team showed that being awake caused damage to mitochondria found in a specific set of neurons. Once this damage reaches a threshold it kicks off a process that ultimately leads to sleep. Although it’s unclear if this process occurs in humans, the researchers think this need for sleep may be an ancient process that coincided with the evolution of organisms with power-hungry nervous systems.Research Article: Sarnataro et al.23:04 The secret messages used to trick peer-review AIResearchers have been sneaking text into their papers designed to trick AI tools into giving them a positive peer-review report. Multiple instances of these prompts have been found, which are typically hidden using white text or an extremely small font invisible to humans. We discuss the rise in this practice and what is being done to tackle it.Video: Could hidden AI prompts game peer review?Nature: Scientists hide messages in papers to game AI peer reviewThree weeks in a hide to spot one elusive bear: the life of a wildlife film-maker
12:47|Vianet Djenguet is an award-winning wildlife film-maker and camera operator whose work has featured in a number of major nature documentaries.In this podcast, Vianet joins us to talk about his career, how wildlife film-making have changed, and his experiences working with local researchers to capture footage of endangered animals on the new television series The Wild Ones.The Wild Ones Apple TV+ (2025)Music supplied by SPD/Triple Scoop Music/Getty ImagesAncient DNA reveals farming led to more human diseases
37:06|00:48 The past 35,000 years of diseaseAncient DNA evidence shows that the advent of agriculture led to more infectious disease among humans, with pathogens from animals only showing up 6,500 years ago. The DNA, extracted from human teeth, shows the history of diseases present in Eurasia over tens of thousands of years. The approach used could be a powerful way to understand how illness has shaped humanity, but it is unable to detect some bacteria that enter the bloodstream at low concentrations or some viruses, so future work could seek to fill that gap.Research Article: Sikora et al.News: Animal diseases leapt to humans when we started keeping livestock10:58 Research HighlightsDNA studies confirm that sardines were a major ingredient of the Roman Empire’s favourite fish sauce, and how analysis of animal manure identified global hotspots for antibiotic-resistance genes.Research Highlight: Ancient DNA helps trace stinky Roman fish sauce to its sourceResearch Highlight: Poo of farm animals teems with drug-resistance genes13:17 Using whale poo to study toxic algae in the ArcticA 19-year experiment sampling bowhead whale faeces reveals a link between warming Arctic waters and increasing levels of toxic algae, researchers say. While climate change is expected to drive increases in the prevalence of harmful algal blooms, long-term data is lacking. To address this, a team worked with indigenous communities to collect and sample whale poo, showing that increases in algal toxins in the Arctic food chain are linked to rising ocean temperatures. The researchers suggest levels of these toxins need to be closely monitored to protect Arctic communities that depend on marine resources for food.Research Article: Lefebvre et al.24:06 Briefing ChatAn object from beyond our solar system has been spotted zipping past Jupiter, and evidence that Neanderthals created ‘fat factories’ to extract vital nutrients from animal bones.Nature: Neanderthals boiled bones in ‘fat factories’ to enrich their lean dietNature: Rare find: interstellar visitor seen blazing through our Solar SystemSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Audio long read: How to speak to a vaccine sceptic — research reveals what works
16:13|Questions and doubts about vaccines are on the rise worldwide and public-health specialists worry that these trends could worsen. But while the shift in public attitudes towards immunizations can leave scientists, physicians and many others feeling disheartened, a surge of research on vaccine hesitancy is starting to offer ways to address the issue.This is an audio version of our Feature How to speak to a vaccine sceptic: research reveals what works3D-printed fake wasps help explain bad animal mimicry
27:19|In this episode:00:45 Why animals evolve to be imperfect mimicsMany harmless animals mimic dangerous ones to avoid being eaten, but often this fakery is inaccurate. To help explain why evolution sometimes favours imperfect mimicry, a team 3D printed a range of imaginary insects. The novel creatures were designed to mimic wasps with varying degrees of accuracy and the team then presented these models to different predators. They showed that while birds were hard to fool, invertebrate predators were less able to discern between the mimics and accurate wasp models. The results suggest that predator perception plays a key role in the level of accuracy needed to fool them and may help explain the existence of inaccurate mimics in nature.Research article: Taylor et al.News and Views: 3D printing offers a way to study mimicry by insects12:53 Research HighlightsRitual ‘retirement’ rather than family feud may explain broken statues of a female pharaoh, and how kelp ‘loofahs’ made by killer whales might be the first example of toolmaking by a marine mammal.Research Highlight: The shattered statues of Queen Hatshepsut: the reasons for the wreckageResearch Highlight: Killer whales exfoliate each other with home-made scrubbers15:02 Briefing ChatThe sea slugs that steal chloroplasts to snack on, and the researchers re-enacting a Stone Age sea-voyage.Nature: ‘Wildest thing’: solar-powered slug steals chloroplasts and stores them for emergenciesNature: These scientists re-enacted Stone Age voyage to Japan’s remote islandsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.- 31:30|We’d like to learn more about our listeners, please help us out by filling in this short survey.In this episode:00:45 Is AI-research being co-opted to keep track of people?A significant amount of research in the AI field of computer vision is being used to analyse humans in ways that support the development of surveillance technologies, according to new research. By analysing the contents of thousands of research papers, the team behind the work showed that 90% of studies, and 86% of patents resulting from them, involved data relating to imaging humans. While there are many positive applications for this technology, such as in medical diagnostics, this work shows evidence of a pipeline from computer-vision research to surveillance.Research article: Kalluri et al.News and Views: Computer-vision research is hiding its role in creating ‘Big Brother’ technologiesVideo: Is AI powering Big Brother? Surveillance research is on the riseNews: Wake up call for AI: computer-vision research increasingly used for surveillanceEditorial: Don’t sleepwalk from computer-vision research into surveillance09:38 Research HighlightsA minuscule robot that can manipulate liquid droplets, and the sensors that can identify hydrothermal explosions at Yellowstone National Park.Research Highlight: This tiny robot moves mini-droplets with easeResearch Highlight: Sensors pinpoint the exact time of a Yellowstone explosion12:12 The first images from the world’s largest digital cameraThis week, the Vera C. Rubin Observatory in Chile has unveiled the first images from its 3,200 megapixel digital camera. We discuss the images, and how the facility will help researchers learn more about the Universe.News: First images from world’s largest digital camera leave astronomers in awe19:18 Briefing ChatHow scientists created hexanitrogen, a new molecule made of six nitrogen atoms, and the why researchers are excited about the first confirmed skull of an extinct Denisovan.Chemistry World: Most energetic molecule ever made is stable – in liquid nitrogenNature: First ever skull from ‘Denisovan’ reveals what ancient people looked like
Flight simulator for moths reveals they navigate by starlight
30:37|We’d like to learn more about our listeners, please help us out by filling in this short survey.In this episode:00:45 The tiny moths that use the stars to navigateBogong moths use the stars to help them navigate during their enormous migration across Australia, according to new research. Every year, billions of these nocturnal moths travel up to 1,000 km to cool caves in the Australian Alps, despite having never been there before. By placing moths in a flight-simulator that also acted as a planetarium, the team behind the work showed that moths could use the bright Milky Way to help them fly in the correct direction.Research article: Dreyer et al.10:17 Research HighlightsNigeria's pangolins are under threat because their meat is delicious, and how the gravitational pull of other galaxies may prevent the Milky Way colliding with Andromeda.Research Highlight: Why pangolins are poached: they’re the tastiest animal aroundResearch Highlight: A long-predicted cosmic collision might not happen after all12:37 How humans expanded their habitats before migrating out of AfricaNew research suggests that shortly before modern humans successfully migrated out of Africa, they massively expanded the range of ecosystems they lived in. By combining climate modelling with data from archaeological sites across the African continent, researchers put forward evidence that 70,000 years ago, humans expanded the ecosystems they lived in to include diverse habitat types from forests to deserts. The authors suggest this ability to live in different places may have helped the later humans that migrated out of the continent around 50,000 years ago.Research article: Hallet et al.21:59 Briefing ChatBlowing bubble-rings could be humpback whales' way of trying to communicate with humans, and the research suggesting that everyone’s breathing pattern is unique.Science Alert: Humpback Whale Bubble Rings May Be an Attempt to Communicate With UsNature: How you breathe is like a fingerprint that can identify youSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Hundreds of physicists on a remote island: we visit the ultimate quantum party
09:07|According to legend, physicist Werner Heisenberg formulated the mathematics behind quantum mechanics in 1925 while on a restorative trip to the remote North Sea island of Heligoland.To celebrate the centenary of this event, several hundred researchers have descended on the island to take part in a conference on all things quantum physics. Nature reporter Lizzie Gibney was also in attendance, and joined us to give an inside track on the meeting.News: Happy birthday quantum mechanics! I got a ticket to the ultimate physics party