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14. Let's Talk About Hormonal Sensitivity
01:05:18Welcome to this episode with Vibe Froekjaer, Professor in Neuropsychiatry at the Department of Clinical Medicine, Copenhagen University, Denmark. Join us as Vibe and Franziska delve into the question of why some women are more vulnerable to mental health problems during hormonal transitions, unraveling state of the art research on the hypothesis of “hormonal sensitivity”. From discussing the latest findings on genetic and neural mechanisms to the potential of psychoeducation, this episode promises an insightful conversation and valuable takeaways. Discover how understanding hormonal sensitivity can empower women to navigate their mental health journeys more effectively and hear Vibe sharing her vision on the final question: “What is the next question to solve regarding hormonal sensitivity across the female lifespan – and how could we do so?”Timestamps:00:02:10 - The "3 P's" across the female lifespan: puberty, pregnancy & perimenopause00:08:02 - Incidence of mental health problems across the female lifespan: windows of vulnerability?00:09:14 - Why are some women more prone to suffer from hormone-related mental health problems?00:16:57 - Hormonal-related depressive symptoms and the role of serotonin00:19:26 - Hormone variability and gene expression00:26:12 - Large-scale changes in the brain in response to induced hormone variability00:29:02 - Hormonal manipulation effects on reward responses00:33:41 - Is hormonal sensitivity a phenomenon that translates across the lifespan?00:42:03 - What epidemiological data from Denmark tell us about risks for depressive symptoms across transition years00:44:00 - Can we identify women who are hormone sensitive?00:47:41 - What could be preventive and treatment approaches for women identified as hormone-sensitive before hormonal transition phases?00:52:56 - How the concept of hormonal sensitivity can reduce stigma involved in depressive symptoms and empower women00:56:03 - Summary00:58:41 - What is the next question to solve regarding hormonal sensitivity across the female lifespan – and how could we do so?01:03:50 - Closing remarksSound recording: Franziska Weinmar with the equipment of the IRTG2804Editing: Franziska WeinmarDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg2804
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13. Let's Talk About Research on Hormonal Contraceptives
49:05In this episode, PhD candidate Franziska Weinmar interviews Dr. Adriene Beltz, visiting Tübingen from the University of Michigan. The topic of today’s episode are hormonal intrauterine devices, short IUD. From contraceptives beyond the “pill” and hormonal contraceptive trends worldwide, they discuss how the IUD works, why it is important to look at potential effects of IUDs separately from oral contraceptives and what research there is on the IUD and mental health as well as the brain. Further, they discuss how a specific method of research, “intense longitudinal data”, can help understand individual variability within people to do better science and go towards individualized medicine. Timestamps:01:30 Hormonal contraceptives beyond the “pill”05:00 Trends in contraception worldwide / by age06:45: How does the hormonal IUD work?08:15: Hormonal levels in IUDs10:30 Systemic IUD effects?12:30 Combining OC and IUD in research?15:00 IUDs in neuroscience research and types of progestins23:10 IUD & the brain25:50 Why is it so important to investigate hormonal contraceptives and IUDs specifically?29:30: Summary34:00 Outlook with focus on methods37:30 Intense longitudinal data – what is it and why is it important40:00 Paths to individualized medicine?42:00 Diversity in research via intensive longitiudinal data45:00 Summary and teaser for future episodes on stress & the IUDMany thanks to Zoé Bürger for contributing to this episode!Sound recording: Franziska Weinmar with the equipment of the IRTG2804Editing: Franziska WeinmarDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg280412. Let's Talk About Hormonal Fluctuations Across the Female Lifespan
01:14:43Welcome to a special episode, coming to you live and on-site from the Lorentz Center in Leiden, the Netherlands!The Lorentz Center serves as a dynamic workshop hub, hosting international scientific meetings which bring together brilliant minds and foster an open and interactive atmosphere. In this episode, PhD Candidate Franziska Weinmar is taking you directly to the Lorentz workshop on "Hormonal fluctuations across the female lifespan". With 40 participants including researchers and clinicians from approximately 6 countries, this five-day intensive gathering in February 2024 promises lively exchanges, discussions, and reflections.Join Franziska as she takes you through a series of 9 conversations, capturing the very fresh impressions and thoughts from different participants. Get ready to hear the pulse of the workshop, where ideas converge and minds collide – all in pursuit to move the field of research and clinical practice forward. And stay tuned for the announced outcomes! Speakers, in order of appearance:00:01:38: Ellen de Bruijn, Professor, Leiden University00:10:19: Birit Broekman, Medical Specialist, Amsterdam UMC00:15:33: Anne Marieke Doornweerd, PhD Candidate, Utrecht University00:27:25: Klara Sifalakis-Spalek, Postdoctoral Researcher, Amsterdam UMC00:34:36: Alkistis Skalkidou, Professor, Uppsala University00:40:12: Lotte Gerritsen, Associate Professor, Utrecht University00:46:4: Hanna Wierenga, PhD Candidate, IRTG 2804, University of Tübingen00:52:50: Claudia Barth, PhD, Diakonhjemmet Hospital Oslo01:03:09: Birgit Derntl, Professor, IRTG 2804, University of Tübingen01:12:10 Closing RemarksMany thanks to the Lorentz Center for providing the space and opportunity for this workshop!Sound recording: Franziska Weinmar with the equipment of the IRTG2804Editing: Franziska WeinmarFollow the FLAME (Female Lifespan Association for Mental Health and Neuroendocrinology) for future updates: https://www.linkedin.com/company/female-lifespan-research-initiative?trk=public_post-textDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg280411. Let's Talk About the Parental Brain
57:52Tune in to this episode for an enlightening conversation on the profound transformations of the brain in transition to mother- and parenthood: PhD candidate Franziska is interviewing Dr. Magdalena Martínez-García, researcher in the “Neuromaternal” group in Madrid. Using longitudinal neuroimaging studies, she and her team investigate structural and functional neuroplasticity across different stages of pregnancy and beyond. Don't miss out and join us when we dive into how (and why) both the maternal and paternal/parental brains are shaped by pregnancy, experience as well as time shared with the offspring.Timestamps:00:00 Introduction 01:44 What happens during pregnancy within the mother's body?04:00 What is neuroplasticity?06:05 Neuroplasticity during pregnancy18:18 Do pregnancy-related changes in the brain reverse?23:35 Why does the brain of mothers-to-be change?27:20 Why we should NOT be scared of pregnancy-related neuroplasticity and brain volume shrinkage!32:02 What are neural plasticity mechanisms during pregnancy in human mothers?37:01 Research on brains of fathers and parents42:03 Time spent with the child matters: experience-induced plasticity43:46 What is the importance of research on the parental brain?47:20 Summary 50:25 The next step in research on neuroplasticity of peripartum and parenthoodMany thanks to Julia Siódmiak for contributing to this episode!Sound recording: Franziska Weinmar with the equipment of the IRTG2804Editing: Franziska WeinmarDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg280410. Let's Talk About Stress & Stress Regulation
58:55With our first episode in 2024, we are back and ready to talk about stress and stress regulation! In this episode PhD candidate Franziska Weinmar hosts Dr. Lydia Kogler, a clinical psychologist by training, expert on the neuroscience of stress and associate of the IRTG2804. Together they dive into the complex world of stress and stress regulation - especially if and how women and men differ in this regard. To this end, this episode leaves us with more insights, a suggestion on how to improve our resilience to stress, and curiosity for future talks on this topic!Stress is part of our everyday life. But what does stress mean and how does the body react to stress? In this episode Lydia explains:01:21: What is stress? (01:21)05:30: How does the stress response leads to behavioural and endocrine adaptations?08:28: The role of cortisol11:49: How do we induce stress in the lab?14:22: What neurological changes come with stress?15:34: How chronic stress affects the body...18:58: ... and mental healthNext, Lydia talks about sex/gender differences:22:58: Sex differences in the stress response...26:25: ... its neural basis....27:17: ... and psychological effects28:00 Sex differences in stress related disorders30:18: Reasons behind sex differences33:50: Consequences of sex differences in stress response35:15: Why is it important to look into sex differences?39:24: Mechanisms of stress regulation44:49: How self-esteem influences the stress response49:00: Sex differences on a neuronal level...50:03: ... and a hormonal level50:18: Implications of coping mechanisms52:00: Summary54:57: What is the next question to ask about sex/gender differences in stress response or regulation, especially considering female-specific processes? Many thanks to Anna Denninger for contributing to this episode!Sound recording: Franziska Weinmar with the equipment of the IRTG2804Editing: Franziska WeinmarDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg28049. Let's Talk About the Power of Natural Rhythms
49:47In this episode, we're hosting cognitive neuroscientist Prof. Sara Mednick who is visiting Tübingen all the way from the University of California, Irvine. Being an expert in biorhythms, she explains the importance of natural up- and downstates such as related to sleep, the menstrual cycle and the transition to menopause. What are biorythms and how can we use especially downstates to improve our wellbeing? How can we use the knowledge on hormonal changes to balance our mood and cognition? Sara is here to give us a new perspective on our natural rhythms!Timestamps: 01:30 What are biorythms?03:31: What is the power of downstates?06:42: How can we use biorythms & downstates for our wellbeing & cognition?08:00: Sleep as restorative downstate12:40: What is the menstrual cycle?14:32: How does the menstrual cycle affect other biorythms?15:50: Sleep as mood buffer during the menstural cylce21:40: A change in prespective on the menstrual cylce30:40: Changes in sleep in the transition to menopause34:22: Subjective vs. objective measures of sleep & cognition39:45: Wellbeing during (the transition) to menopause42:53: Summary44:40: A future vision for women's mental health: awareness, reseach & empowerement.Sara's popular-scientific books: https://www.saramednick.com/books"The Power of the Downstate: Recharge Your Life Using Your Body's Own Restorative Systems" (2022)"Take a Nap! Change Your Life. The Scientific Plan to Make You Smarter, Healthier, More Productive" (2006)Thanks to Nina Röhm for supporting & exchanging ideas in preparation of this episode!Sound recording: Nina Röhm with the equipment of the IRTG2804Editing: Franziska WeinmarDo you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg28048. Let's Talk About Psycho-Neuro-Immunology in Pregnancy
41:36In this episode we talk about one of the major transition periods many women will undergo throughout their life: pregnancy. How does the field of psych-neuro-immunology help us to understand pregnancy and related mental health problems? From Uppsala in Sweden, PhD Candidate Franziska Weinmar is interviewing Dr. Emma Fransson, a child psychologist and associate professor at Uppsala University and at the Karolinska Institute in Sweden. Emma’s research focuses on mental and reproductive health, specifically in identifying biomarkers for pregnancy-related complications. These include mental health problems such as postpartum depression, which is affecting up to one in five women after giving birth. Dive with us into the interactions of the immune system, the brain, and psychological wellbeing, as we outline what is happening during pregnancy, what makes some women vulnerable for depression associated to pregnancy, and how we can use this information in the future. Timestamps:01:30 What happens during pregnancy? 05:10 What is “psycho-neuro-immunology”?07:35 Pregnancy as a psycho-neuro-immunological transition phase 09:05 What factors contribute to postpartum depression? 11:55 Major depression and postpartum depression: Differences and subtypes? 14:50 Inflammatory markers during pregnancy: Risk for postpartum depression?18:15 Predictive markers for postpartum depression? 20:40 Screening and prediction of depressive symptoms across the postpartum period 25:45 Preventive approaches of postpartum depression: Using psycho-neuro-immunology.29:18 What do we know about the pregnant brain? 33:24 How does postpartum depression affect the child? 36:36 Summary38:33 What is the next big step for research in psychoneuroimmunology during pregnancy, especially when considering pregnancy-related mental health? Thanks to Hanna Wierenga for exchanging ideas in preparation of this episode!Sound recording: Recording Studio Blasenhus, Uppsala University Editing: Franziska Weinmar with support from Andreas Forsberg (Recording Studio Blasenhus, Uppsala University) Do you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg2804