Brain In Progress

What if one of the biggest problems in brain medicine isn’t the drugs—but getting them to the brain?Seema Mathur speaks with Dr. Chad Gordon, a Neuroplastic and Reconstructive Surgeon at Johns Hopkins School of Medicine, about a bold new innovation: a skull-brain implant designed to bypass the brain’s natural defenses and deliver medicine exactly where it’s needed.This conversation explores what could be the next frontier in brain medicine—potentially changing the fate of those facing serious neurological disease, as well as anyone hoping to protect and enhance brain health as they age.In This Episode:A powerful and personal conversation about hope, persistence, and innovation in medicineUnderstanding the blood-brain barrier—how it protects us while also blocking life-saving treatmentsThe “aha moment” that led to NeuroPASS, a first-of-its-kind implant designed to deliver medicine past the blood-brain barrierHow this innovation could change outcomes for patients with brain cancer and transform treatment for conditions like seizures, Parkinson’s, dementia, depression, and moreThe future of brain medicine—and what it could mean for brain health and healthy aging

Seema Mathur sits down with Dr. S. Thomas Carmichael—neuroscientist, neurologist and Chair of Neurology at UCLA—to explore a question that could change stroke recovery: What if a pill could help repair the brain?Stroke is a leading cause of adult disability, and even with intense therapy, many people never fully regain movement—especially in the arm and hand. Dr. Carmichael explains neuroplasticity and the brain’s “sensitive period” after stroke, when the brain is most open to rewiring. He then shares the science behind a surprising target: a receptor called CCR5, which becomes highly active after stroke and can lock down the brain’s ability to form new connections. His team is studying whether blocking CCR5—using a drug originally developed for HIV—could help “reopen” plasticity and strengthen recovery.Seema also reflects on her own experience with neuroplasticity and what it means to fight your way back—one repetition at a time.In this episode:Why stroke recovery is often limited—even with rehabWhat neuroplasticity really is (and what it isn’t)The brain’s post-stroke “sensitive period” and the window of opportunityCCR5: the molecule that may limit recovery by locking down connectionsWhy an FDA-approved HIV drug is now in clinical trial for stroke rehabilitationWhat researchers hope to improve most: meaningful arm and hand functionIf the treatment could be extended to multiple variations of traumatic brain injury

In the premiere episode of Brain In Progress, Seema Mathur sits down with ABC News journalist—and longtime friend—Kyra Phillips for the most personal conversation of her career.Seema shares the story she has never told publicly: her brain tumor diagnosis at 19 and what it means to live today with a second rare, currently incurable brain disease. She reflects on how being close to death can make embracing life feel unmistakably clear.This episode introduces Seema—and launches her deeper exploration of the brain in future episode conversations.In this episode:The moment everything changedThe fortune of surviving multiple brain conditions and brain traumaUsing your life for purposeLiving with ongoing uncertaintyWhy Seema is launching Brain In Progress now

Award-winning medical journalist Seema Mathur turns her journey with brain disease into purpose. Her story — how Western medicine is saving her life and Eastern practices help her heal — becomes the thread that launches a deeper exploration of the brain.In Brain In Progress, Seema speaks with the world’s leading neuroscientists, physicians, and integrative experts to investigate the future of brain health — from neuroplasticity and brain implants to meditation and consciousness.This is a show about possibility. About resilience. About unlocking the brain’s potential and deepening our understanding of the organ that shapes how we perceive ourselves and the world.