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Methamphetamine, psychosis and family history with Rebecca McKetin
In this episode Ben Scher talks to Dr Rebecca McKetin about her recent article looking the relationship between psychosis, psychotic symptoms and methamphetamine use. They discuss the implications and talk about who exactly is at risk of methamphetamine-related psychosis. Along the way, they cover the background of methamphetamine use in Australia and how this varies from country to country.
They then discuss the relative risk for psychotic symptoms among people with and without a family history of psychosis. The risk also changes when people are (or are not) actively using methamphetamine. Rebecca also talks about the potential for people to progress to schizophrenia and how treatment services should respond. Rebecca talks about the range of interventions that could be used to address methamphetamine related risks use and drug-related mental health problems.
Original article: How does a family history of psychosis influence the risk of methamphetamine-related psychotic symptoms: Evidence from longitudinal panel data by Rebecca McKetin and colleagues. Published in Addiction (2023)
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24. Pregnancy and opioids with Jerry Cochran
20:24In this episode Ben Scher talks to Professor Gerald (Jerry) Cochran about his article based on a randomized multisite pilot trial investigating the impact of Patient Navigation. Jerry begins by describing Patient Navigation, explaining how it works and how it can help people stay engaged in care. The research team explored whether this approach helps pregnant people to stay in contact with treatment services.Jerry then go on to discus the next steps for his research and explains how his research findings might be scaled up to influence policy. Jerry describes how Patient Navigation could be implemented within US Medicaid programmes summarising the data that would be needed to scale up the intervention. They then reflect on the economic implications for Medicade or state insurers."That's really exiting and it's really satisfying when you're able to identify a partner like a Medicaid programme or a large pharmacy chain.... and help them integrate into their workflow into their systems something that might help patients and think 'oh wow'. You know, not only could we help patients in a single clinic but we could help people in a state or across the country"Original article: Patient Navigation for Pregnant Persons with Opioid Use Disorder: Results of a Randomized Multisite Pilot Trial by Gerald Cochran and colleagues. Published in Addiction (2023)The opinions expressed in this podcast reflect the views of the hosts and authors and do not necessarily represent the opinions or official positions of the SSA or Addiction journal.The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information.23. Minimum unit pricing and road traffic accidents with Francesco Manca
25:45In this episode Rob Calder talks to Francesco Manca about his research on Scotland's Minimum Unit Pricing (MUP) policy for alcohol, and specifically about the impact that MUP has had on road traffic accidents. Francesco discusses how the research team selected appropriate comparitors to assess whether changes to road traffic accidents could be attributed to MUP. He also talks about how this study compares with previous studies that used similar datasets yet drew different conclusions. He describes how understanding the subtle differences between time frames and outcomes can aid researchers to gain an in-depth understanding of alcohol regulation. "The original 50 pence as a floor price .... maybe too low over the years as it can be eroded by external factors such as inflation - so maybe indexing with inflation may create a more consistent effect of the policy over time"Original article: Evaluating the impact of minimum unit pricing for alcohol on road traffic accidents in Scotland after 20 months: an interrupted time series study by Francesco Manca and colleagues. Published in Addiction (2023)The opinions expressed in this podcast reflect the views of the presenter and interviewee and do not necessarily represent the opinions or official positions of the SSA.The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information.22. Mental health and social care with Amy O'Donnell and Kat Jackson
35:54In this episode, Zoe Swithenbank talks to Drs Amy O'Donnell and Kat Jackson about their recent study on how to improve care for people with coexisting heavy drinking and depression. The discuss the theoretical concept of Relational Autonomy and how it influenced their research. Amy and Kat describe how they set up the research, and in particular the challenges of recruiting participants from groups where your research is not their priority. They also talk about how much work it takes to conduct effective PPI (Patient and Public Involvement) and how important it is to do it well. They then go through their findings, discussing how they can inform theory and clinical practice: "A lot of people who we spoke to literally didn't have anybody. They'd been turned away from every formal health and social care service that they needed to access and they also didn't have any family relationships or friendships for various reasons. How are you supposed to get better if you don't have those?" Original article: Understanding people's experiences of the formal health and social care system for co-occurring heavy alcohol use and depression through the lens of relational autonomy: A qualitative study by Katherine Jackson and colleagues. Published in Addiction (2023)The opinions expressed in this podcast reflect the views of the interviewer and interviewees and do not necessarily represent the opinions or official positions of the SSA.The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information.21. Smoking cessation trials with Zoe Swithenbank
25:51In this episode, Rob Calder talks to Zoe Swithenbank about her recent article looking at how to improve research reports on smoking cessation trials. Zoe talks about the challenges of organising an international meeting of experts before the COVID-19 pandemic (before people were used to online working). She talks about some common errors and omissions that researchers make when reporting smoking cessation trials and how these can place limits on scientific progress. She talks about developing the CONSORT-SPI tool to help improve the ability of researchers to draw conclusions across studies."It was important to get that balance and try and get a good range, and we did have quite a variety of people...different backgrounds, different expertise which made for some interesting debates."Original article: Tailoring CONSORT-SPI to improve the reporting of smoking cessation intervention trials: An expert consensus study by Zoe Swithenbank and colleagues. Published in Addiction (2023)20. Drug Consumption rooms with Laurence Lalanne
20:29In this episode Ben Scher talks to Professor Laurence Lalanne about drug consumption rooms and the recent publication based on the COSINUS cohort study. They cover the range of interventions available in drug consumption rooms and how they can increase people's access to psychiatric support alongside barriers to accessing drug consumption rooms. Laurence talks about the epidemiological point of view in relation to the more biomedical aspects of drug consumption rooms, their objectives in reducing overdose and their impact on hospitals and the wider health-care system. "You need a very long follow-up....we need to follow for two years and three years to show important results about mental health and to see how they improve their well-being and access to other care."This is the second of a two-part podcast. The first, featuring Dr Marie Jauffret-Roustide, can be found here.Original article: Drug consumption rooms are effective to reduce at-risk practices associated with HIV/HCV infections among people who inject drugs: Results from the COSINUS cohort study by Laurence Lalanne and colleagues. Published in Addiction (2023).19. Drug consumption rooms with Marie Jauffret-Roustide
37:57In this episode Ben Scher talks to Dr Marie Jauffret-Roustide about drug consumption rooms and the recent publication based on the COSINUS cohort study. They cover a range of issues including the history of drug consumption rooms, the evidence on effectiveness and the challenges of studying this particular intervention.They also reflect on the social determinants of health and how drug consumption rooms can have a positive impact"We have 1% of people who attend drug consumption rooms who declared having ever shared injecting equipment in the last month before the interviews compared to 11% for people who were not exposed to drug consumption rooms"This is the first of a two-part podcast. The second, featuring Professor Laurence Lalanne can be found here.Original article: Drug consumption rooms are effective to reduce at-risk practices associated with HIV/HCV infections among people who inject drugs: Results from the COSINUS cohort study by Laurence Lalanne and colleagues. Published in Addiction (2023).18. Drones delivering Naloxone with Caroline Copeland, Patrick Courtney and Paul Royall
28:06In this episode, Rob Calder talks to Drs Caroline Copeland, Patrick Courtney and Paul Royall about their recent article assessing the time it would take for drones to deliver naloxone to people who are overdosing on opioids. The study team used NPSAD (National Programme on Substance Abuse Deaths) data to map out overdoses in Teeside over recent years and then to predict how long it would have taken a drone to make the journey and deliver naloxone to a bystander who would then be able to administer it. They then compared this time with the time it takes ambulances to attend the scene. Along the way they discuss take off stations, weather, traffic congestion, no-fly zones and the importance of considering whether a drone will be destroyed along the way."The initial design we came up with was a sort of cargo transport box on top of the drone, whereby the drone lands and then the bystander can remove the naloxone home kit or naloxone nasal spray from the top of that transport holder. At that point we then follow the guidance and recommendations of the at home naloxone or nasal spray." - Paul RoyallOriginal article: An evaluation of naloxone transit for opioid overdose using drones: A case study using real-world coroner data. By Caroline Copeland and colleagues. Published in Addiction (2023)17. Canadian low-risk drinking guidelines
40:16In this episode Dr Merve Mollaametoglu talks to Dr Catherine Paradis director of health promotion and scientific alcohol lead at the Canadian Centre of Substance Use and Addiction, Dr Kevin Shield from the Centre for Addiction and Mental Health in Toronto and Dr Peter Butt clinical associate professor Department of Family Medicine at the University of Saskatchewan.They discuss their recent article looking at ways of making of low-risk alcohol drinking guidelines. They talk about how difficult it is to reach consensus on low-risk alcohol thresholds and how scientific evidence and public opinion meet. And the development of their ‘risk-zone’ approach. And how this can be interpreted by people who had differing perceptions of risk.They talk about why people in alcohol focused cultures appear to be willing to accept a higher rate of risk from alcohol than they do from other risk-based activities."I would liken the development of the risk-zones the risk curves allowing people to situate themselves to other scientific discoveries….A lot of other public health agencies and a lot of people who have been involved in the development of these guidelines really are taken to the utility of those risk zones and hopefully we’ll see that picked up in a lot more guidelines as well” - Dr Kevin ShieldOriginal article: New perspectives on how to formulate alcohol drinking guidelines by Kevin Shield and colleagues. Published in Addiction (2023).16. Social media and alcohol with Brandon Cheng
17:27Dr Elle Wadsworth talks here to Brandon Cheng about his research on social media posting and drinking behaviour. Brandon talks about the influence that media and social media have on young people and how they can influence their drinking behaviour.“A young person watching a short video of people enjoying drinks [is] likely to develop a much more vivid imagery of what drinking can be like … compared to a viewer just to see an image or text relating to someone having a good time drinking.”Original article: A systematic review and meta-analysis of the relationship between youth drinking, self-posting of alcohol use and other social media engagement (2012 – 2021) by Brandon Cheng and colleagues. Published in Addiction (2023).