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cover art for Part I: Why We Breathe

The Look Up! Podcast with Marc Weinstein

Part I: Why We Breathe

Season 3, Ep. 15
The Most Important Thing

How can something as simple as breathing impact our health and optimize performance? Famous for his breakthrough contributions within the field of breathing, sighing, and discovering the pre-botzinger complex. Jack Feldman takes us through almost four decades of his career, researching and discovering a process we all take for granted, breathing. 

About the Guest

Jack Feldman is a distinguished Professor of Neurobiology, he also holds a Ph.D. in Physics and is currently teaching at UCLA. 

His contributions to understanding the mechanisms of breathing and sighing include the pre-Bötzinger complex and demonstrating the essential role in generating respiratory rhythm in fetal, neonatal, and adult mammals. Jack Feldman’s influence is evident in numerous highly cited reviews, textbooks, and lectures. He was awarded the prestigious Hodgkin, Huxley, Katz Prize of The Physiological Society.

About “what Jack Feldman does

Professor Feldman’s laboratory focuses on the central problem confronting neuroscientists: how molecular, synaptic, and cellular properties of individual neurons in densely interconnected networks result in behaviors ranging from playing the piano to writing a book. Through a unique model system that enables them to perform studies that address this issue, Feldman and his colleagues are able to test their current hypothesis: pacemaker neurons underlie the generation of respiratory rhythm

Episode Overview

In part one of this episode, we got to speak to Professor Jack Feldman about his research into the field of breathing, sighing, and developing the Pre-Botzinger Complex. Jack broke down his journey of how he got into the research, conducting crazy experiments and took almost a decade trying to convince people of the importance of breaths.

Jack also took a few moments to highlight how a study into brain stems kickstarted his interest in the topic of the brain breath connection.

My Favorite Quotes

“You can't do anything interesting if you're afraid of failing and I'm willing to bet that that's something that people in your realm also follow.”

“You make investments, but some of the best investments are the things that might ultimately fail, but they could be spectacular.”

“One of the challenges in science is that the technology progresses and sometimes the technology allows you to answer questions that are very important. You can answer before. The problem with that is that we're under a lot of pressure as scientists to keep producing. And when a new technique comes along, you have to learn it sometimes have to spend a lot of money to get the equipment necessary to do that and that the tracks, your productivity.”

“Just like your car has one engine. We thought there would be a single-engine for breathing. We discovered about 15 years later that there appears to be a second engine and one engine is devoted to generating the inspiratory rhythm and the other is involved in generating rhythm.”

“I realized that the literature was just simply wrong and we embarked upon a series of crazy experiments to try and see if we could localize a site for generating breathing. I wouldn't say much to my surprise that we identified a relatively small spot in the brainstem that seemed to be critical for the generation.”

“You have to be resilient and you have to be persistent. At some point, you have to believe that you have an idea that's worth pursuing. ”

“You have to be careful where you become too much of a believer in an idea because things often, even good ideas get overturned as science progresses, and you have to be able to recognize it.”

Episode Breakdown (Part 1)

03:17 - Jack’s most surprising discovery about brain + breath connection

08:30 - Closely held belief of how breath was generated

16:51 - When and why Jack started researching breathing

20:40 - How the study of breathing came about 

33:00 - How a scientific peer review could make or break an experiment or theory

Catch the rest of the episode in part 2

Episode Links

Professor Jack Feldman’s Info

Jack Feldman - Instagram

Jack Feldman - LinkedIn

Jack’s scientific journals - Google Scholar 

Jack Feldman’s UCLA Profile and Publications


References made in the episode

Breathing Matters Video

Breathing Matters Article

Science.org

Nature.com

In Search of Memory, Eric Kandel

Marc’s Info

Look Up! Patreon Community

Look Up! Website

Marc's Instagram

Marc's Twitter

Look Up! On iTunes

Look Up! On Spotify


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  • 9. Empowering Labor in the Metaverse with Gabby Dizon founder of Yield Guild Games

    59:35
    The Most Important ThingThe Open Metaverse is paving the way for labor equality by tearing down borders between different worlds. The future of work in the Open Metaverse will be full of opportunities for those in economically challenged nations. When Labor is as liquid as capital, more value will be captured by workers than investors. About GuestBeing in the gaming industry for 18 years, Gabby Dizon is one of the first movers in the industry and one of the earliest members of the blockchain game developer community. Started in 2014, Gabby co-founder Altitude Games, a mobile and blockchain game developer that is based in Manila, Philippines. Today, they have developed and published games such as Battle Racers on Decentraland and Mushroom Mandia on Sandbox that is coming soon.Last year, he co-founded Yield Guild Games, a play-to-earn gaming guild that invests in NFT assets and aggregates players across the Metaverse. Gabby is a founding board member of the Blockchain Game Alliance.About Yield Guild GamesYield Guild Games (YGG) is a decentralized gaming guild of players and investors who generate yield from NFT-based blockchain games and virtual worlds. It is the largest guild within Axie Infinity and has assets in games such as The Sandbox, F1® Delta Time , Axie Infinity , and possibly others in future too. Yield Guild allows players to contribute their time and effort in virtual worlds to earn an income from these games, while the guild accumulates the best yield-bearing assets in the Metaverse.Episode OverviewIn this episode, Marc and Gabby touched on the future of the Metaverse and how blockchain technology is slowly closing the gap between the world around us with new infrastructure and technological revolutions such as Cryptocurrency and Non-Fungible Tokens (NFT). They also spoke about Gabby's company, Yield Guild Games, and how that opportunity is changing the Gig Economy in the Philippines and globally.My Favorite Quotes"This [Blockchain] is the most exciting thing I've seen in my entire career."."A blockchain or non fungible tokens means that I own these items forever. I can trade them any time I can sell them, I can build things on top of them and this is a really new and exciting concept that I think people are only trying to re-understand how to take advantage of."“Blockchain games or virtual worlds that have crypto based economies you can earn through contributing your time and your skill to earn money.""You're starting a new country and then there's so much to build and so much to do. You just got to go out there and apply whatever skill you have to help build this new world and it creates an equal playing field in the metaverse perhaps more so than it is kind of in our physical reality.""[In the Philippines] Everyone is in the hospitality industry, a lot of people were laid off and a lot of these people found Axie infinity and the remarkable thing was, these people weren't crypto users. They're people who were really desperate. They knew how to play games and they were onboarded to the crypto [game] because they wanted to play these games to basically save their families.""I guess the biggest frustration of me being a technology entrepreneur in the Philippines is that the business environment and the investing environment here didn't understand what I wanted to do. I wanted to build intellectual property."Episode Breakdown05:20 - Gabby's views of the Open Metaverse 07:00 - Why are NFT important?14:50 - Gabby’s journey as a tech entrepreneur20:25 - The current state of the Metaverse22:00 - Explaining Yield Guild Games and the people behind it33:30 - Gabby’s vision on the future of the Metaverse42:57 - Will our lives be coupled into the Metaverse47:00 - Growing up in the Philippines 53:00 - Outro PlugsEpisode LinksGabby's Info Gabby’s TwitterGabby’s LinkedInAltitude GamesNarra Art GalleryYGG Info Yield Guild GamesYGG in VentureBeatYGG MediumYGG Investment AnnouncementNotable LinksWhat is the MetaverseWhat are NFTsCrypto KittiesAxie InfinityDelphi DigitalMore about Play to EarnMarc's Info Look Up! WebsiteMarc's InstagramMarc's TwitterLook Up! On iTunesLook Up! On Spotify

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