Methylation. Leaky gut. MTHFR. Biological age. Functional testing. Peptides.  These words are everywhere in health and wellness right now — but what do they actually mean, who are they relevant for, and how should they be approached?

Methylation. Leaky gut. MTHFR. Biological age. Functional testing. Peptides. These words are everywhere in health and wellness right now — but what do they actually mean, who are they relevant for, and how should they be approached? In this episode of The Health Review, I sit down with Dr Jean-Marc Sobczyk from HOOKE clinic in London— a physician dual-trained in both conventional and naturopathic medicine, with deep expertise in advanced functional testing, methylation and root-cause health.&nbsp; He's at the cutting edge of methylation science and runs a dedicated platform on the MTHFR gene and its implications for health. This is one of the most clinically rich conversations I've had on the podcast — and one that I think will genuinely change how you think about your own health. We cover: What methylation actually is — and why it underpins energy, detox, hormone balance, mood and longevityThe B vitamins that support the methylation cycle and how to use them intelligentlyMTHFR, COMT and other gene variants — what they mean in practice and how common they areHow poor methylation shows up clinically: anxiety, burnout, hormonal issues, fatigue, low resilienceMethylation and women's health — PMS, fertility, pregnancy prep, perimenopauseThe gut-methylation connection: why liver function and gut health are inseparable from how well you methylateLeaky gut and reactive gut — how to identify it, calm it and repair itProbiotics: when they help and when they don'tBiological age testing, peptides and longevity medicine — what's worth it and what's noiseThe foundational things to focus on before spending money on complex testing This episode is for you if: You've been told your bloods are normal but you still don't feel well. You struggle with fatigue, anxiety, hormonal imbalance, gut issues or brain fog — and you want to understand what might actually be driving it. About Dr Jean-Marc Sobczyk: Dr Jean-Marc Sobczyk is a physician dual-trained in conventional and naturopathic medicine. He practises at HOOKE, a longevity and preventative medicine clinic, where he uses advanced functional testing alongside natural and integrative therapies to address root-cause health. He has a specialist focus on methylation and the MTHFR gene. This episode is for educational purposes only and does not constitute medical advice. Always consult your own clinician before making changes to your health. Topics: methylation | MTHFR gene | COMT | functional medicine | leaky gut | gut health | probiotics | biological age | peptides | longevity medicine | B vitamins | hormone balance | oestrogen detox | dopamine | neurotransmitters | personalised medicine | preventative health | anxiety and nutrition | women's hormones | perimenopause nutrition | fatigue root cause | naturopathic medicine Dr Jean-Marc Sobczyk: https://www.instagram.com/mthfr_expert/ HOOKE: https://www.hooke.london/ Follow The Health Review: https://www.instagram.com/the.health.review/

Why You're Exhausted, Anxious & Hormonally Wrecked — And What Methylation Has To Do With It | Dr Jean-Marc Sobczyk

Longevity medicine, mitochondrial health, methylation testing, peptides, hormones, gut health — but why do so many people doing "all the right things" still feel flat, foggy, and far from themselves?

Longevity medicine, mitochondrial health, methylation testing, peptides, hormones, gut health — but why do so many people doing "all the right things" still feel flat, foggy, and far from themselves? In this episode of The Health Review, I sit down with Dr Ash Kapoor (MRCGP), founder of Levitas Clinic and a longevity and human optimisation physician with over 30 years of clinical experience. This isn't a biohacking checklist — it's a deeper conversation about how the body actually works, why physiology and mental clarity are inseparable, and what most longevity conversations leave out entirely. We cover: Why mitochondrial health is the foundation most people overlook Hormones, gut health and stress physiology — and where Dr Ash starts with patients Methylation testing: genuinely useful or overcomplicating your health? Peptides and IV therapies: what the evidence shows and where caution is warranted Why you cannot think, meditate or mindset your way out of poor physiology Ancient wisdom, stillness and the intelligence of the body The real order of longevity priorities — simplified This episode is for you if: You've optimised your sleep, tracked your nutrition, tried the supplements — and still don't feel like yourself. About Dr Ash Kapoor: Dr Ash Kapoor MRCGP is a longevity and integrative medicine physician and founder of Levitas Clinic. He brings together 30+ years of conventional medical training with functional, preventive and ancient wisdom practices to help people optimise how they feel and age. This episode is for educational purposes only and does not constitute medical advice. Always consult your own clinician before making changes to your health. Topics: longevity medicine | mitochondrial health | methylation | peptide therapy | IV therapy | hormones and energy | gut health | biohacking | human optimisation | integrative medicine | functional medicine | stress physiology | ancient wisdom | meditation and health Levitas clinic: https://levitascliniclondon.com/Dr. Ash: https://www.instagram.com/drashkapoor Follow The Health Review: https://www.instagram.com/the.health.review

Ancient Wisdom, Modern Longevity Medicine & Why Your Body Holds the Answers | Dr Ash Kapoor

What if healing the body isn’t only about protocols, supplements, and lifestyle — but also about energy and spirituality? And how do we explore that idea?

What if healing the body isn’t only about protocols, supplements, and lifestyle — but also about energy and spirituality? And how do we explore that idea? In this episode, I’m joined by Emilie Weston, lead practitioner at Sun Kyeong London, who shares her personal journey from living with ME (chronic fatigue syndrome) and trying countless wellness approaches… to discovering Sun Kyeong — a South Korean-rooted spiritual practice focused on restoring and strengthening what they describe as life-force energy (Qi). Together, we explore the power of spirituality — not as a vague concept, but as a practical path to returning to our natural state (compassion, joy, gratitude, peace, vitality). Emilie explains how she found her own spiritual path through ancient wisdom practices, and how that transformed not only her health, but her whole relationship with life. In this conversation, we cover: Emilie’s journey through ME / chronic fatigue and what finally helped after years of trying different wellness practices Energy explained in a grounded way: what it is, and why it matters for healing the body The two types of energy that support wellbeing: the energy we’re born with (life-force / universal energy), and nature’s energy (food, water, sunlight) — with Emilie’s brilliant “battery + petrol” analogy Energy blockages: how they form, how to spot them, and why they can show up as physical symptoms Family patterns, ancestors, inherited energy, and how Emilie bridges spirituality with ideas like epigenetics and karma Where to start with Sun Kyeong: energy treatments vs energy classes vs ancestor healing (and how to choose) If you’ve ever felt depleted, heavy, stuck in repeating patterns, or like your healing needs a deeper layer — this conversation will be helpful and could open up a completely different lens for you. Note: This episode is for education and exploration and isn’t medical advice. If you have persistent symptoms, please speak to a qualified healthcare professional. Visit Sun Kyeong London: https://www.sunkyeong.org.ukhttps://www.instagram.com/sunkyeonglondon/https://www.instagram.com/emilieweston/ Follow The Health Review: https://www.instagram.com/the.health.review/

Energy & Spirituality: Can You Heal the Body Through Qi? (Life Force Energy)

In this episode of The Health Review, neuroscientist Anne-Sophie Fluri (founder of Brainwave) explains how AI and constant digital stimulation are reshaping our brains, and what we can do to protect focus, motivation and mental resilience.

If you feel like your attention is getting worse — and your brain is constantly “on” — you’re not imagining it. In this episode of The Health Review, neuroscientist Anne-Sophie Fluri (founder of Brainwave) explains how AI and constant digital stimulation are reshaping our brains, and what we can do to protect focus, motivation and mental resilience. We break down what mental fitness actually means and how neuroplasticity works in adults, and the real role of dopamine in attention, drive and phone habits. We also explore whether a “dopamine diet” is useful and the simple, science-backed habits that help you rewire your brain for clarity in a distracted world. In this episode, we cover: How AI is changing attention, learning and critical thinking What “mental fitness” is (and how to train it) Neuroplasticity as an adult: how change really happens Dopamine and phone addiction: what’s going on under the hood Do we need a dopamine diet — and what does that even mean? Practical tools to build resilience, focus and cognitive strength 🎧 Listen here and on all podcast platforms / Subscribe for weekly evidence-based health conversations with incredible guests. Brainwave: https://wearebrainwave.co/Anne-Sophie's IG: https://www.instagram.com/coochiebygucci/The Health Review: https://www.instagram.com/the.health.review/ #neuroscience #dopamine #neuroplasticity #mentalhealth #focus #ai

Mental Fitness in an AI World: Neuroplasticity, Dopamine & Focus | Anne-Sophie Fluri

If you feel like you can’t stop scrolling, struggle to focus, or reach for your phone the moment you feel bored, stressed or uncomfortable — you’re not alone.

We all say we’re “just checking something.” And then suddenly it’s 40 minutes later. If you feel like you can’t stop scrolling, struggle to focus, or reach for your phone the moment you feel bored, stressed or uncomfortable — you’re not alone. In this episode of The Health Review, I sit down with Colin Corby, also known as The Digital Detox Coach, to explore what constant digital stimulation is doing to your brain, your attention span and your nervous system. We talk about: Why it feels so hard to stop scrolling The psychology behind compulsive phone habits How notifications and multitasking fragment your focus The hidden cost of constant stimulation Why willpower isn’t enough to change digital behaviour How to create a realistic digital detox without quitting modern life Practical tools to regain clarity, presence and control This conversation isn’t about demonising technology. It’s about learning how to use your phone — without it using you. If your focus has slipped, your mornings start with scrolling, or your attention feels scattered, this episode will help you reset. Colin's website: https://thedigitaldetoxcoach.com/Colin's Instagram: https://www.instagram.com/the_digital_detox_coachFollow The Health Review: https://www.instagram.com/the.health.review/

Digital Detox: Why You Can’t Stop Scrolling (And How to Break the Habit) with Colin Corby

If you feel wired but exhausted, struggle to switch off, experience poor sleep, anxiety, or constant overwhelm, the issue may not be mindset — it may be nervous system dysregulation.

Chronic stress has become so normal that many of us no longer recognise when our nervous system is stuck in survival mode. If you feel wired but exhausted, struggle to switch off, experience poor sleep, anxiety, or constant overwhelm, the issue may not be mindset — it may be nervous system dysregulation. In this episode of The Health Review, Emily speaks with Jane Ollis — medical biochemist, environmental scientist, Oxford business fellow, and founder of SONA, an AI-powered vagus nerve stimulation platform designed to retrain the body’s stress response. Together, they explore how the nervous system really works, why modern life keeps us stuck in fight-or-flight, and what it actually means to feel calm and regulated. Jane explains the role of the vagus nerve, heart rate variability (HRV), and autonomic balance — and why true recovery requires retraining the body, not just managing stress. They also discuss the future of adaptive neurostimulation, how personalised technology can support resilience and sleep, and why nervous system regulation may become one of the most important tools in preventive health and performance medicine. 🎧 Exclusive listener offer: Jane has kindly offered The Health Review listeners 15% off SONA. Use code THR at checkout or access the discount automatically here: https://sona.pxf.io/c/7022575/3799822/43388 Check out SONA: https://sona.helpFollow The Health Review: https://www.instagram.com/the.health.review/

The Vagus Nerve Explained: Calm Your Body & Rewire Stress

We’re living in a world our bodies were never designed for — microplastics, environmental chemicals, chronic stress, and constant stimulation. So what does detox really mean in 2026?

We’re living in a world our bodies were never designed for — microplastics, environmental chemicals, chronic stress, and constant stimulation. So what does detox really mean in 2026? In this fascinating and forward-looking conversation, I’m joined by Alanna Kit — co-founder of Arc Community and a PhD researcher in behavioural and cognitive neuroscience — who is working at the cutting edge of integrative health, nervous system regulation, and psychedelic research. We explore detox beyond diets and supplements, the role of inflammation and stress in modern illness, and why small, intentional stressors may actually make us more resilient. Alanna also shares insights into her upcoming clinical research with UCL examining brain activity during cold exposure using EEG technology — and discusses whether cold plunging is truly harmful for women’s hormones, or if the reality is more nuanced. We discuss: What “detox” really means in modern life Microplastics, chemicals &amp; invisible stressors affecting health Cold exposure, sauna &amp; the science of hormesis Whether cold plunging impacts women’s hormones Why sauna after cold exposure may support recovery Stress as a tool for resilience rather than something to avoid The nervous system’s role in healing &amp; inflammation Psilocybin research and its potential impact on mental health &amp; chronic inflammation How inflammation may affect the blood-brain barrier Why community is essential for healing in a post-pandemic world The rapid growth of Arc Community and its vision for integrative wellness This episode offers a science-led look at how we build resilience, support detox pathways, and rethink healing in the modern world. Visit Arc: https://www.arc-community.com/ Follow The Health Review: &nbsp;https://www.instagram.com/the.health.review/

The Science of Detox, Cold Exposure & Nervous System Healing | Alanna Kit

Chronic symptoms. Normal test results. And the phrase no one wants to hear: “It’s all in your head.”

Chronic symptoms. Normal test results. And the phrase no one wants to hear: “It’s all in your head.” In this episode of The Health Review, I’m joined by health psychologist and psychotherapist Dr Sula Windgassen, author of It's All In Your Body, to explore what’s really happening when symptoms like IBS, fatigue, chronic pain, bladder issues and burnout persist — even when doctors can’t find clear answers. Dr Sula shares her own experience of chronic health struggles that were dismissed, and explains how the nervous system, immune system and brain can become stuck in “threat mode.” We discuss: – Why symptoms can continue even when tests are normal– The science behind the mind–body connection– IBS, chronic fatigue and nervous system dysregulation– Trauma and burnout in the body– Why being told “it’s stress” can make things worse– How to work with your body rather than fight it This is not just about positive thinking or overnight fixes. It’s about understanding symptoms through a biopsychosocial lens — and rebuilding trust with your body. If you’ve ever felt dismissed, stuck or frustrated by persistent symptoms, this conversation will resonate. Dr Sula's website &amp; new book:https://www.healthpsychologist.co.uk/https://www.healthpsychologist.co.uk/itsallinyourbody Follow The Health Review: https://www.instagram.com/the.health.review

Managing Chronic Illness — When It’s Not “All In Your Head”

Chinese medicine is no longer on the fringes.    In 2026, practices like acupuncture, acupressure and gua sha are firmly in the mainstream — with more people in the West turning to them to manage stress, burnout, digestive issues and chronic tension.

Chinese medicine is no longer on the fringes. In 2026, practices like acupuncture, acupressure and gua sha are firmly in the mainstream — with more people in the West turning to them to manage stress, burnout, digestive issues and chronic tension. But why now? And is there real science behind a healing system that’s more than 2,500 years old? In this episode of The Health Review, I’m joined by Katie Brindle — who's been a Chinese Medicine Practitioner since 2002, and founder of Hayo’u as well as author of the bestselling book Yang Sheng, which translates to “nourishing life”. We explore: why Chinese medicine is surging in popularity in the West how its core principles compare to modern medical thinking what the science actually says about acupuncture and acupressure the role of the nervous system, digestion and emotional health in healing and why balance — not optimisation or perfection — sits at the heart of this ancient system Katie offers some fantastic advice for simple things we can add into our busy lives to make Chinese medicine part of our health routine. Katie's website: https://www.katiebrindle.com/Hayo'u: https://hayoumethod.com/Follow The Health Review: https://www.katiebrindle.com/ If you love the show, please do hit the subscribe button! Every subscription goes a really long way. Thank you :)

The Science of Chinese Medicine — and Why the West Is Turning to It in 2026

I’m Emily — a TV journalist and presenter on a mission to cut through the noise and find real answers about how we can take care of our health. After struggling with chronic health issues for years — from recurring infections to gut problems and burnout — I made some big lifestyle changes that completely transformed my life. Now, I use my journalism background to ask the questions we all really want answered. On The Health Review, I speak to top doctors, nutritionists, and experts to make sense of the science and debunk the endless health myths online. Subscribe for weekly episodes with incredible health and wellness voices!