Share

Foresight Institute Radio
Nir Barzilai | Targeting Aging with Metformin
“We are here representing the field of the science of aging. And we think that this is a historical day for us, because we're going to offer something that will be paradigm changing.”
Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research.
In this episode, Dr. Nir Barzilai presents the current state of the groundbreaking TAME trial serving as a framework and data springboard for the whole longevity field, as well as the future plans for other TAME-like trials with other drugs with high potential for repurposing for aging. At the end, he also answers questions about the trial itself and why it is designed the way it is, but also some frequently asked questions about Metformin, like its effect on muscle building with exercise, the ideal dosing, and others.
Music:
Candlepower by Chris Zabriskie is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/
Session summary: TAME Q&A: Lessons for Progress on Aging | Nir Barzilai, Albert Einstein School of Medicine - Foresight Institute
The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.
Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize.
Apply to Foresight’s virtual salons and in person workshops here!
We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.
Visit our website for more content, or join us here:
More episodes
View all episodes

Viren Jain | Connectomics and AI @ Vision Weekend USA 2025
09:38|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Steve Jurvetson | Investing in AI Moonshots @ Vision Weekend USA 2025
16:22|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Sonia Arrison | Lobbying for Longevity Progress @ Vision Weekend USA 2025
14:46|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Richard Ngo | Identity & Meaning in SciFi Futures @ Vision Weekend USA 2025
12:09|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Joshua Elliott | The Hail Mary Phase of Climate Change @ Vision Weekend USA 2025
13:26|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
John Hallman & Rico Meinl | Accelerating Life Sciences @ Vision Weekend USA 2025
17:09|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Jesse Posner | Fiduciary AI: The New Architecture of Freedom @ Vision Weekend USA 2025
15:15|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Haleh Fotowat | Harnessing Biological Intelligence for Building Living Machines with Nervous Systems
09:55|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.
Eli Dourado | Thoughts on Philanthrocapitalism @ Vision Weekend USA 2025
11:56|This talk was recorded live at Vision Weekend USA, held December 5–7, 2025 in the Bay Area. Vision Weekends are our flagship conference series, bringing together leading scientists, entrepreneurs, funders, and policymakers to explore frontier science and technology and to imagine paths toward flourishing futures.