The Existential Hope Podcast

Nuclear energy has a reputation problem. Despite being one of the safest and most reliable clean-energy technologies ever developed, public perception is dominated by a handful of accidents, Cold War imagery, and decades of political resistance. Isabelle Boemeke, model-turned-science-communicator and author of Rad Future, argues that this disconnect is not only irrational, but actively dangerous for humanity’s prospects.In this episode, Isabelle explains how nuclear became one of the most misunderstood technologies of the last century, why fears about waste, safety, and proliferation are often overstated, and what the data actually shows about nuclear relative to fossil fuels, hydropower, and renewables. She also talks about her unusual path to becoming the first “nuclear influencer,” why she thinks communication and aesthetics matter just as much as engineering, and why abundant, cheap energy is central to improving global living standards.Beyond nuclear itself, the conversation touches on broader questions:• Why are young people increasingly pessimistic about the future?• What explains the rise of degrowth thinking in wealthy countries?• How does meaning shift in a world where technology automates more of life?• And what would it take for the U.S. and Europe to build again at the pace of China?‍This special episode was recorded at the 2025 Progress Conference. Enormous thanks to Roots of Progress for organizing the event, and to Lighthaven for providing the podcast studio.

What if the biggest driver of economic growth isn’t new technology, but simply fixing what’s broke, housing, transport, and energy?Sam Bowman, editor of Works in Progress, joins us to explore how smarter cities, faster transit, and abundant energy could unlock human potential on an unprecedented scale. We discuss why restrictive zoning laws keep millions from opportunity, how beauty and design shape public attitudes toward progress, and why rediscovering growth could restore optimism in the West.Sam also shares what he’s learned from success stories around the world, from Houston’s neighborhood-led zoning reforms to Madrid’s low-cost metro expansion, and why he believes rebuilding belief in progress is just as important as building the future itself.This special episode was recorded live at the 2025 Progress Conference, hosted by our friends at Roots of Progress. We’re grateful to them for bringing together so many thinkers reimagining how humanity can keep moving forward—and for making conversations like this one possible!

What if we could treat depression, anxiety, or chronic pain by tuning the brain, just as precisely as a pacemaker regulates the heart?Jacques Carolan, Program Director at the UK’s ARIA (Advanced Research and Invention Agency), joins us to talk about the next wave of precision neurotechnology; new tools that let us see and influence brain activity with far greater accuracy. We explore how ultrasound might gently stimulate mood circuits without surgery, how gene therapies could switch off seizures before they start, and how “living electrodes” could one day repair damaged brain tissue.Jacques also explains ARIA’s bold approach to funding high-risk science, what he’s learned from patient engagement, and why he believes the next decade will transform how we understand and care for the brain.

What if chronic diseases, from Alzheimer’s to autoimmune conditions, share a hidden cause: lingering infections deep within our tissues?Microbiologist Amy Proal, co-founder of the PolyBio Research Foundation, joins host Allison Duettmann to discuss how persistent pathogens could drive inflammation, aging, and many chronic illnesses, and why our current “autoimmunity” model might be missing the root cause.They explore PolyBio’s groundbreaking work collecting rarely studied tissue samples, the link between viruses and Alzheimer’s, the rise of long COVID, and simple tools, like clean indoor air, that could prevent future pandemics. Amy also outlines an optimistic vision: strengthening, not suppressing, the immune system to build a healthier, more resilient civilization.

In this episode, Ken Liu joins the podcast to explore how science fiction serves as our modern mythology. We discuss his new techno-thriller "All That We See or Seem", the concept of egolets (AI capturing facets of our identity), the noematograph (AI as a camera for thought), and the role of collective dreaming in making us more human. Ken also reflects on Frankenstein, Philip K. Dick, the challenge of translation, and why technology is “the mind made tangible.” Ken's new book is now available to buy: https://www.amazon.com/All-That-Seem-Julia-Novel/dp/1668083175/ref=sr_1_1?crid=YQBXYV3NPYRQ&dib=eyJ2IjoiMSJ9.qZEp-FJsQjZ1DeI_1aU9dUCHVQLskKq0l80APpXt8lY._8ZY1FJprDwz6sXFyMqa538OZaQZx-_KzsBkHjRww1g&dib_tag=se&keywords=ken+liu+all+that+we+see+or+seem&qid=1758810447&sprefix=ken+liu+all%2Caps%2C326&sr=8-1

In this episode of the Existential Hope Podcast, Beatrice Erkers is joined by David Duvenaud, Associate Professor at the University of Toronto and former researcher at Anthropic.We discuss David’s work on post-AGI civilizational equilibria and the widely discussed paper Gradual Disempowerment. David reflects on why liberalism may not hold up in a world where humans are no longer needed, how UBI could be Goodharted into absurdity, and what it would take to design institutions that protect humans even when incentives don’t.We also cover:- Forecasting the long-term future using LLMs trained on historical data- Robin Hanson’s idea of futarchy (governance by prediction markets)- Asymmetrical but beneficial relationships between humans and AI- Uploading, cultural legacies, and the possibility of “worthy successors”

What does a genuinely positive future with AI look like? While dystopian visions are common, the most valuable—and scarcest—resource we have is a concrete, hopeful vision for where we're headed.In this episode, we're joined by Nathan Labenz, host of the popular Cognitive Revolution podcast, to explore the tangible possibilities of a beneficial AI-driven world. Nathan shares his insights on everything from the near-term transformations in education and healthcare—like AI-driven antibiotic discovery and personalized learning—to the grand, long-term visions of curing all diseases and becoming a multi-planetary species.We dive deep into crucial concepts like Eric Drexler's "comprehensive AI services" as a model for safety through narrowness, the transformative power of self-driving cars, and how we can collectively raise our ambitions to build the future we actually want.

For years, the conversation about the long-term future has been dominated by a crucial question: how do we avoid extinction? But what if ensuring our survival is only half the battle? In this episode, Beatrice is joined by Fin Moorhouse, a researcher at Forethought and co-author with Will MacAskill of the Better Futures series, to make the case for focusing on the other half: flourishing. Or as we'd like to say in this podcast: Existential Hope!Fin challenges the idea that a great future will emerge automatically if we just avoid the worst-case scenarios. Using the analogy of a grand sailing expedition, he explores the complexities of navigating towards a truly optimal world, questioning whether our current moral compass is enough to guide us.The conversation dives into the concept of "moral catastrophes"—profound ethical failings, like industrial animal farming, that could persist even in technologically advanced futures. Fin also tackles the complex challenges posed by digital minds, from the risk of accidental suffering to the creation of "willing servants." He argues for the power of "moral trade" as a tool to build a more pluralistic and prosperous world, and explains why we should aim for a "Viatopia"—a stable and self-sustaining state that makes a great future highly likely.