The Doctor's Farmacy with Mark Hyman, M.D.

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The Untold Story Of Uric Acid: Solving The Puzzle Of Obesity, Diabetes And Chronic Disease with Dr. David Perlmutter

Ep. 495

This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.


Uric acid is a central player in metabolic mayhem. Despite its long association with gout and kidney stones, it’s involved in so much more—especially our metabolic disease epidemic. There are three things that raise our levels of uric acid: purines, alcohol, and fructose. The latter is the biggest challenge, due to its overwhelming presence in our Standard American Diet. That doesn’t mean all fruit is bad or even that all alcohol and purine-rich foods have the same effect. Like all parts of health and nutrition, there are nuances we need to consider to create optimal health.


That’s why I’m so excited to take a deep dive into the topic of uric acid with my friend and colleague Dr. David Perlmutter. Dr.Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain among others, and his new book, Drop Acid was just released. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.


This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.


Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account here.


Thrive Market is an online membership-based grocery store that makes eating well convenient and more affordable. Join today to receive an extra 40% off your first order and a free gift worth over $50 here.


Cozy Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, use code MARK40 to get 40% off your Cozy Earth sheets here.


Here are more details from our interview (audio version / Apple Subscriber version): 


  • What is uric acid and how does it affect our health? (5:30 / 2:00) 
  • The impact of fructose consumption on our physiology (11:45 / 8:10) 
  • The differences between fructose and glucose (19:20 / 16:29) 
  • Why high fructose corn syrup is used in so many foods (21:13 / 17:40) 
  • The three sources of uric acid (22:57 / 19:23) 
  • Fructose consumption, uric acid, and gut health (28:19 / 23:43) 
  • How to eat to reduce uric acid (33:54 / 28:52) 
  • Medications that increase uric acid (47:07 / 42:04)  
  • Uric acid and Alzheimer’s (50:28 / 45:28) 
  • Heavy metals, supplements, sleep, exercise, and uric acid (54:12 / 49:14)


Get Dr. Perlmutter’s new book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health here.

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