The Doctor's Farmacy with Mark Hyman, M.D.


The Real Reason For America’s Obesity Crisis And Chronic Disease Epidemic with Dr. David Kessler

Only about 12% of Americans are considered “metabolically healthy.” That means the other 88% of us aren’t meeting basic medical guidelines for things like blood pressure, blood glucose, cholesterol, and other markers of metabolic health. Which percentage do you fall into? When it comes to answering that question, one common factor is how many fast carbs you’re consuming. These are the carbohydrates that have been processed—yes, that includes sugar—but it also means starches like refined flours and other processed grains. Whole wheat bread is indeed a fast carb. 

This week on The Doctor’s Farmacy I sat down with Dr. David Kessler to break down the differences between fast and slow carbs, how they affect our health, how our diet became so inundated with fast carbs and what we can do to regain metabolic strength. Dr. Kessler served as commissioner of the U.S. Food and Drug Administration under presidents George H. W. Bush and Bill Clinton. He is the author of A Question of Intent and The End of Overeating, a New York Times bestseller. He is a pediatrician and has been the dean of the medical schools at Yale and the University of California, San Francisco. Dr. Kessler is a graduate of Amherst College, the University of Chicago Law School, and Harvard Medical School.

This episode is sponsored by AirDoctor and AquaTru. We need clean water and clean air not only to live but to create vibrant health and protect ourselves and loved ones from toxin exposure and disease. That’s why I’m teaming up with AquaTru and AirDoctor to offer you the AquaTru Water Purification System and AirDoctor Professional Air Purifier systems at a special price. Learn more at

Here are more of the details from our interview: 

  • Why 87% of Americans are metabolically unhealthy (7:03)

  • What are fast carbs and how do processed carbohydrates affect us? (12:38)

  • The glycemic index of bread is higher than that of table sugar (18:41)

  • How processed carbs made from grains, corn, and wheat became the foundation of our diet (19:34)

  • The food industry’s resistance to clear ingredient lists and labels on food (23:20)

  • What are slow carbs? (26:02)

  • Why we should all be able to get behind the idea of limiting fast carbs (32:00)

  • Dr. Kessler’s own struggle with his weight, our tendency to turn to comfort foods in stressful time, and why it’s so difficult to break the vicious cycle that results from eating fast carb (33:29)

  • The need for additional reform to the government’s dietary guidelines and how regulation differs in its oversight of the food industry vs the tobacco industry (41:08)

  • Industry will follow the consumer (57:39)

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How To Recover From Chronic Lyme And Tick Diseases with Dr. Todd LePine

Lyme disease and other tick-borne diseases often go undiagnosed or are misdiagnosed. This is partially because Lyme mimics other illnesses such as the flu, manifesting as diverse symptoms including headaches, muscle aches, stomach ulcers, constipation, and joint pain, making diagnosing and treating Lyme very difficult. Left unchecked, Lyme symptoms can worsen, creating a long-running inflammatory response and autoimmune illness. Lyme disease, or borreliosis, is caused by the bacterium Borrelia burgdorferi, which can proliferate to every area in your body. The good news is that with some work and effort, you can successfully treat Lyme disease.In this episode, Dr. Hyman sits down with Dr. Todd LePine to discuss the Functional Medicine approach to identifying and treating chronic Lyme and other tick-borne diseases.Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders and the neurobiology of mood and cognitive disorders. Dr. LePine teaches around the world, and has given lectures to doctors and patients at American College for Advancement in Medicine (ACAM), Age Management Medicine Group (AMMG), the University of Miami Integrative Medicine Conference, The Kripalu Center in Lenox, MA, and is on the faculty for American Academy of Anti-Aging Medicine (A4M). Dr. LePine is the head of the Scientific Advisory Board for Designs for Health and a consultant for Diagnostic Solutions Laboratory. He enjoys skiing, kayaking, hiking, camping and golfing in the beautiful Berkshires, and is a fitness enthusiast.This episode is sponsored by AirDoctor. We need clean air not only to live but to create vibrant health and protect ourselves and loved ones from toxin exposure and disease. Learn more about the AirDoctor Professional Air Purifier system at a special price at this episode, Dr. Hyman and Dr. LePine discuss:Why conventional medicine doesn’t acknowledge chronic Lyme diseaseWhy chronic Lyme and other tick-borne illness can present, or exist along with, conditions such as fibromyalgia, chronic fatigue system, autoimmune issues, Parkinson’s disease, Alzheimer’s and dementia, multiple sclerosis, SIBO and other gut issues, depression, and moreWhat syphilis can teach us about Lyme and other tick-borne illnessConventional vs Functional Medicine testing, identification, and treatment for LymeUsing botanicals, herbs, sauna, and sunshine exposure to treat LymeCan you get rid of Lyme?Off-the-grid therapies for Lyme including stem cells, exosomes, hyperbaric oxygen, hyperthermia, ozone therapy, and peptidesFor more information visit Resources:“7 Strategies To Tackle Lyme Disease”“Getting to the Root Cause of MS and Chronic Fatigue Syndrome”“The Myth of Diagnosis”“Innovative Treatments for Chronic Disease Not Available in the US”“My Journey to Functional Medicine”

Do You Have To Eat A Ketogenic Diet All Of The Time To Get Its Benefits? with Mark Sisson

The ketogenic diet has gained a lot of popularity in the past couple of years. If you’re not quite sure what it is, why it could be beneficial, or you’re well-acquainted with it and just want to learn more, this episode is for you. The ketogenic diet, or keto as it’s called, is a high-fat low carbohydrate diet. While some people take this to mean loads of conventionally raised meat and dairy, the true (and beneficial version) means lots of beneficial fats from things like avocados, nuts and seeds, and coconut; high-quality protein from clean sources like grass-fed meat and pasture-raised eggs; and plenty of non-starchy vegetables.To hash out more of the details about keto and how it can support good health, I was excited to talk with my friend and one of the leading voices in the Paleo/Primal and keto movements, Mark Sisson. Mark is the founder of the popular daily health blog, Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint.This episode is sponsored by Joovv, chili, and my Sleep Master Class.I recently discovered Joovv, a red light therapy device. Red light therapy is a super gentle non-invasive treatment where a device with medical-grade LEDs delivers concentrated light to your skin. It actually helps your cells produce collagen so it improves skin tone and complexion, diminishes signs of aging like wrinkles, and speeds the healing of wounds and scars. Check out the Joovv products at and use the code FARMACY at checkout.One of the easiest and most effective ways to get better sleep every single night is through temperature regulation, which is why I was so relieved to discover the transformative products from Chili. The chiliPAD and OOLER system are two really cool gadgets that fit over the top of your mattress and use water to control the temperature of your bed - which helps lower your internal temperature and trigger deep relaxing sleep. Right now chili is offering my audience a really great deal. Get 25% off the chiliPAD with code hyman25 or 15% off OOLER with code hyman15, just go to this modern world we place too much value on staying busy and deprioritizing sleep, which is why I have created my first ever Master Class.It guides you through the most important steps to getting better sleep, starting today. To learn more about the Sleep Master Class, head over to are more of the details from our interview:Mark’s wake-up call to change how he ate and exercised at 28 years old (5:42)Tenets of the Primal Blueprint (13:50)Reversing the aging process through metabolic flexibility (19:36)What is a ketogenic diet? (24:37)How long does it take to adapt to the ketogenic diet and why do people get the “keto flu”? (33:15)Can you eat too much on the ketogenic diet? (35:53)The way to know if you’re doing a ketogenic diet properly (39:28)Weightlifting and the importance of muscle, especially as you age (41:12)Why burning fat is better than burning sugar for longevity (44:21)Do you have to be “keto” all of the time to get the benefits of a ketogenic diet? (53:02)Find Mark online at and follow him on Facebook @marksdailyapple, on Instagram @marksdailyapple, and on Twitter @Mark_SissonGet Mark’s latest book Keto for Life at

How COVID-19 Shines A Light On Our Broken Food System with Dr. Dariush Mozaffarian

Only 12% of us in the US are metabolically healthy—it’s pretty alarming when the healthy population is the minority. And in the age of COVID-19, it’s important to recognize that those with a chronic disease are at an exponentially higher risk of hospitalization than someone who is metabolically healthy. If we as a population were healthier (think less obesity, type 2 diabetes, cardiovascular disease, cancer, etc.), the evidence supports that we’d be faring much better throughout this pandemic. Of course, a major driver of chronic diseases and the risks they create is our food system. We can’t expect to be a resilient population if we aren’t feeding our bodies real food with real nutrients we can use to function optimally.To dig into this topic further, I was excited to sit down with Dr. Dariush Mozaffarian on this episode of The Doctor’s Farmacy. Dr. Mozaffarian is a cardiologist, Dean and Jean Mayer Professor at the Tufts Friedman School of Nutrition Science and Policy, and Professor of Medicine at Tufts Medical School. As one of the top nutrition institutions in the world, the Friedman School’s mission is to produce trusted science, future leaders, and real-world impact. Dr. Mozaffarian has authored more than 400 scientific publications on dietary priorities for obesity, diabetes, and cardiovascular diseases, and on evidence-based policy approaches to reduce these burdens in the US and globally. He has served in numerous advisory roles including for the US and Canadian governments and, in 2016, Thomson Reuters named him as one of the World’s Most Influential Scientific Minds.For context, this interview was conducted on April 30, 2020.Here are more of the details from our interview:Three ways COVID-19 influences food and nutrition, and visa versa (3:28)How our national health and economic outcomes from COVID-19 might be different were we a metabolically healthy society(7:37)We can improve our metabolic health in real time (9:53)Micronutrients and their potential for preventing and reducing COVID-19 severity(11:32)Strategies to address our chronic disease pandemic and problems with our food system (28:41)How obesity is affecting our military and national security (33:23)Why we need a coordinated national organizing office around food and nutrition policy (48:18)Functional Medicine for our food system (54:55)Obstacles to changing and improving our food system (56:12)Educating policymakers through strategic collaboration among stakeholders (1:00:30)Find the “Report of the 50th Anniversary of the White House Conference on Food, Nutrition, and Health: Honoring the Past, Taking Actions for our Future” at Dr. Mozaffarian on Twitter @Dmozaffarian.