The Doctor's Farmacy with Mark Hyman, M.D.


Is Alzheimer’s Preventable? The Power Of A Personalized Medicine Approach with Dr. Richard Isaacson

Ep. 448

This episode is brought to you by Essentia, BiOptimizers, and Joovv.

There are so many simple steps we can take every single day to strengthen our brains and reduce the risk for Alzheimer’s. Considering that this disease starts in the brain 20 to 30 years before the first signs of memory loss, we should all be thinking about prevention. Today, I’m so excited to welcome Dr. Richard Isaacson to talk about taking care of the brain in a whole new way. 


Dr. Richard Isaacson serves as Director of the Center for Brain Health and Director of the Alzheimer’s Prevention Clinic (APC) at Florida Atlantic University’s Schmidt College of Medicine. He previously served as Director of the APC at the Weill Cornell Memory Disorders Program, Assistant Dean of Faculty Development, and Associate Professor of Neurology at Weill Cornell Medicine & NewYork-Presbyterian. He remains as Adjunct Associate Professor of Neurology in the Department of Neurology at Weill Cornell.

This episode is brought to you by Essentia, BiOptimizers, and Joovv.

It’s the perfect time to try Essentia, since they’re having their biggest Black Friday sale of the year. You can get 25% off plus 2 free pillows and an extra $100 off a queen, king, or California king mattress at

For the entire month of November, BiOptimizers is offering up to 10% off every order and access to over $200 in free gifts including books and other great products. Just use the code HYMAN10 at

For a limited time, Joovv is offering $50 off your first order with the code FARMACY at Some exclusions apply.

Here are more of the details from our interview (audio version / Apple Subscriber version): 

  • What you can do today to prevent Alzheimer’s disease (8:40 / 4:02)
  • Using food as medicine to prevent and treat Alzheimer’s disease (12:17 / 8:13)
  • ABCs of Alzheimer's prevention management (17:47 / 14:15) 
  • Tracking your sleep, exercise, blood sugar, and more for brain health (22:48 / 19:12)
  • Eating and fasting for cognitive health (25:02 / 21:32)
  • Approaching Alzheimer’s as a systemic disease that affects the brain, not a brain disease (34:13 / 28:52) 
  • Challenges to applying preventative Alzheimer’s research in patient care (43:08 / 39:09)
  • Is Alzheimer’s reversible? (51:32 / 46:06) 
  • Blood pressure, cholesterol, diabetes, belly fat, and Alzheimer’s disease (58:33 / 53:10) 
  • Hopeful Alzheimer’s patient cases (1:12:05 / 1:04:40) 

Support Dr. Isaacson’s Alzheimer's prevention work at Get access to his free Brain Health Course at and learn more at

More Episodes


What Would Happen If You Stopped Eating Bread For 30 Days?

Ep. 483
This episode is brought to you by Rupa Health and Mitopure.The average American consumes 133 pounds of flour per year. Let that sink in. What we may not realize is that every time we eat white flour, we are harming ourselves. The starch in common wheat, typically known as modern dwarf wheat, raises your blood sugar more than table sugar! Eating a diet high in carbohydrates may affect not just your waistline, but also your brain function, energy, immune system, healthspan, and more.In this episode of my new Masterclass series, I am interviewed by my good friend and podcast host, Dhru Purohit, about how and why to consider giving up bread for 30 days. We discuss why our modern wheat is not a good food choice on a daily basis, how to pause on eating bread for a month or more, why certain kinds of bread may be a better choice than others, questions from our community, and so much more.Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30+ million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.This episode is brought to you by Rupa Health and Mitopure.Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, Great Plains, and more. You can check out a free live demo with a Q&A or create an account at is the first and only clinically tested pure form of a natural gut metabolite called Urolithin A that clears damaged mitochondria away from our cells and supports the growth of new healthy mitochondria. Get 10% off at and use code DRHYMAN10.In this episode, we discuss (audio version / Apple Subscriber version):Three reasons to stop eating bread for 30 days (1:04 / 00:54)Bread’s effect on insulin and blood sugar (5:40 / 5:28)Can bread and/or flour cause leaky gut? (10:13 / 7:50)What to expect when stopping bread for 30 days (13:55 / 13:31)Different kinds of bread and how they impact the body (16:13 / 16:05)Case study of a woman with multiple conditions who healed on an elimination diet (20:27 / 20:18)Questions from our community including eating gluten in other countries, Roundup in wheat, hunger when not eating carbs, and more (23:29 / 23:22)What kinds of bread I eat (28:35 / 28:26)Steps to take now to go bread-free (33:24 / 33:13)Mentioned in this episode:Lynn’s Life Breads

Why You Are Tired All The Time

Ep. 482
This episode is brought to you by Rupa Health, Athletic Greens, and Eight Sleep.Feeling tired during the day may not just be due to a poor night’s sleep. Most of us can relate to feeling run-down and tired, even when we’re getting enough sleep. There are many reasons why your body might not be functioning well during the day.In this compilation episode, I talk to Dr. Steven Gundry and Dr. Elizabeth Boham about the many factors that can impact energy production such as diet, circadian rhythm, movement, gut health, and more. We also get into dietary recommendations, fixing nutritional deficiencies and hormonal imbalances, and much more.Dr. Steven Gundry is one of the world’s top cardiothoracic surgeons and a pioneer in nutrition, as well as medical director at The International Heart and Lung Institute Center for Restorative Medicine. He has spent the last two decades studying the microbiome and now helps patients use diet and nutrition as a key form of treatment. He is author of many New York Times bestselling books including The Plant Paradox, and The Plant Paradox Cookbook, and The Longevity Paradox: How to Die Young at a Ripe Old Age, and just released The Energy Paradox: What to Do When Your Get-Up-and-Go Has Got Up and Gone. He also is the founder of GundryMD, a line of wellness products and supplements, and host of The Dr. Gundry Podcast.Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women’s Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine.This episode is brought to you by Rupa Health, Athletic Greens, and Eight Sleep.Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, Great Plains, and more. You can check out a free live demo with a Q&A or create an account at contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting Sleep’s Pod Pro mattress is so smart that it adjusts your temperature and also gives you individualized recommendations on how to sleep better the next night. To get yours, go to to check out the Pod Pro mattress or mattress cover and save $150 at checkout.