The Doctor's Farmacy with Mark Hyman, M.D.


How To Reverse Your Biological Age with Dr. Kara Fitzgerald

Ep. 481

This episode is brought to you by Rupa Health, BiOptimizers, and Thrive Market.

What if I told you it was possible to reverse your age by three years, in just eight weeks? Well, it is, and today you can learn how. Perhaps the greatest part of this exciting news is that the changes we can make to reverse biological aging are pretty simple and very accessible. The amazing doctor behind this groundbreaking research is my good friend, colleague, and long-time collaborator Dr. Kara Fitzgerald. 

Dr. Fitzgerald is on the faculty of the Institute for Functional Medicine, is an IFM Certified Practitioner, and lectures globally on Functional Medicine. She runs a Functional Medicine Clinic Immersion program for professionals and hosts a podcast series, New Frontiers in Functional Medicine, and an active blog on her website. Her clinical practice is in Sandy Hook, Connecticut. With the Helfgott Research Institute, Dr. Fitzgerald is actively engaged in clinical research on the DNA methylome using a diet and lifestyle intervention developed in her practice. The first publication from the study focuses on the reversal of biological aging and was published this past April in the journal Aging. Her new book, Younger You, as well as her 3 Years Younger Program, have just been released. 

This episode is brought to you by Rupa Health, BiOptimizers, and Thrive Market.

Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs. You can check out a free live demo with a Q&A or create an account here

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Here are more of the details from our interview (audio version / Apple Subscriber version): 

  • Reversing your biological age through epigenetics (6:36 / 3:08) 
  • Initial scientific studies that have shown biological age reversal (9:22 / 5:25) 
  • Dr. Fitzgerald’s 8-week age reversal study design (11:14 / 7:46) 
  • Seminal research around influencing and regulating gene expression through nutritional interventions (25:41 / 20:39) 
  • Using food as medicine (30:35 / 27:19) 
  • How exercise, sleep, and meditation were factored into Dr. Fitzgerald’s study (40:40 / 35:16)
  • Primary findings from Dr. Fitzgerald’s research (47:12 / 41:57) 
  • Practical ways to reverse your biological age (1:01:43 / 56:32) 
  • Influencing gene expression before conception and during pregnancy and infancy (1:04:29 / 59:48) 
  • Aging without declining in health (1:08:06 / 1:04:25) 

Get a copy of Dr. Fitzgerald's book Younger You: Reverse Your Bio Age―and Live Longer here. Learn more about Dr. Kara Fitzgerald at and take her Biological Age Self-Assessment here

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