The Doctor's Farmacy with Mark Hyman, M.D.


How To Conquer Your Mind To Live Your Best Life with Colin O’Brady

Ep. 579

This episode is brought to you by InsideTracker, BiOptimizers, and Comvita.

Several months ago, I took thirty days to be by myself in a secluded Vermont cabin. I had no phone, no podcasts, no music, no TV, no work, and no company—it was just me and my thoughts. And I can’t tell you how refreshed, recharged, and centered I felt after that trip. It can be incredibly hard spending time alone with your inner self, but it’s always rewarding. That’s what today’s conversation with my good friend Colin O’Brady is all about. Colin is a ten-time world record breaking explorer, New York Times bestselling author, entrepreneur, speaker, and expert on mindset.

He is focused on sharing his hard-won wisdom to encourage others to step outside of their comfort zone and unlock their best lives. Colin’s highly publicized expeditions have been seen by millions and his work has been featured by The New York Times, The Tonight Show, BBC, Forbes, and Today. His world-renowned feats include the world’s first solo, unsupported, and fully human-powered crossing of Antarctica, speed records for the Explorers Grand Slam and the Seven Summits, as well as the first human-powered row across Drake Passage. He is a regular speaker at Fortune 100 companies like Nike, Google, and Amazon and top Universities including UPenn, Georgetown, and Johns Hopkins. 

This episode is brought to you by InsideTracker, BiOptimizers, and Comvita.

Right now InsideTracker is offering my community 20% off at

Go to and use code hyman10 at checkout for 10% off your next order of BiOptimizers Magnesium Breakthrough.

Learn more about Comvita at, and enter code Hyman25 for 25% off all Manuka honey and bee products. Note: Does not apply to bundles or sale items.

Here are more details from our interview (audio version / Apple Subscriber version):

  • Colin’s solo crossing of Antarctica (7:44 / 3:27)  
  • The personalized nutrition food bars Colin ate on his expedition (9:37 / 6:55) 
  • The advice Colin’s wife gave him on the first day of his Antarctica crossing (18:51 / 15:51) 
  • How Colin broke out of a period of anxiety and depression (27:24 / 23:53) 
  • Conquering your own mind (31:18 / 27:14)
  • The experience that led me to become a doctor (41:34 / 37:18)
  • Facing the feeling of not having enough time (43:50 / 39:31) 
  • What Colin fears more than dying (47:35 / 43:22) 
  • Becoming unstuck from the zone of comfortable complacency (49:10 / 46:54)
  • The severe burn injury that served as a major turning point in Colin’s life (54:59 / 52:00) 

Learn more about Colin at and get a copy of his new book, The 12-Hour Walk: Invest One Day, Conquer Your Mind, and Unlock Your Best Life, here. Get a copy of Colin’s book, The Impossible First: From Fire to Ice―Crossing Antarctica Alone, here.

More Episodes


Why Most Of Us Are Nutrient Deficient And What To Do About It with Chris Kresser

Ep. 602
This episode is brought to you by Rupa Health, InsideTracker, and Cozy Earth.If you’ve ever wondered if supplements are worthwhile or just create expensive urine, this is the podcast episode for you. While I wish it wasn’t the case, I do believe we need supplements to make up for the nutrients we can no longer get through food alone. It’s extra important to note, though, that not all supplements are created equal. And please keep in mind they’re called “supplements” for a reason, not “replacements”—they are meant to supplement a healthy diet and lifestyle to provide the most impact.Today, I’m excited to take a deeper dive into this topic with one of my most trusted sources when it comes to nutrition and dietary research, Chris Kresser. Chris Kresser M.S., L.Ac. is the co-founder of the California Center for Functional Medicine, the founder of Kresser Institute, the host of the top-ranked health podcast Revolution Health Radio, the creator of, and the New York Times best-selling author of The Paleo Cure and Unconventional Medicine. Chris is one of the most respected clinicians and educators in the fields of Functional Medicine and ancestral health and has trained over 2,000 clinicians and health coaches from over 50 countries in his unique approach. He has recently launched Adapt Naturals, a supplement line designed to add back in what the modern world has squeezed out and help people perform and feel their best.This episode is brought to you by Rupa Health, InsideTracker, and Cozy Earth.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to and use code MARK40.Here are more details from our interview (audio version / Apple Subscriber version):Do we really need to take supplements? (5:14 / 1:54) Why our food is less nutritious than it used to be (13:32 / 10:10) Can you really get your nutrients from food? (15:28 / 12:10) The prevalence of, and most common, nutritional deficiencies (16:27 / 13:35) Testing your nutrient levels (21:35 / 18:25)Symptoms of common nutrient deficiencies (29:03 / 25:05) Can you take too much or overdose on nutrients? (41:57 / 36:58) What to look for in a quality vitamin or supplement (51:37 / 47:10) What nutrients are provided by plant vs animal foods (59:41 / 55:06)  The most nutrient-dense foods (1:10:23 / 1:05:45) Learn more about Chris at and check out his new supplement line, Adapt Naturals.

Simple Practices And Tips For Better Sleep

Ep. 601
This episode is brought to you by Rupa Health, ButcherBox, and Mitopure. Sleep is a keystone of health. Most people know they should get more high-quality sleep, but they don’t really know where to start. But understanding the way our brain and neurotransmitters work means we can hack our sleep to not just feel amazing but to level up our focus, skills, and knowledge. And it’s not all about what happens at night, either—getting the right exposure to light at the right times has a profound impact on our circadian rhythms and the way our bodies transition to sleep. In today’s episode, I talk with Dr. Roger Seheult, Dhru Purohit, and Dr. Andrew Huberman about why optimizing your sleep should be prioritized and how you can get better sleep. Dr. Roger Seheult is currently an associate clinical professor at the University of California, Riverside School of Medicine, and an assistant clinical professor at the School of Medicine and Allied Health at Loma Linda University. Dr. Seheult is quadruple board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine, and Sleep Medicine through the American Board of Internal Medicine. He is also the cofounder of MedCram, an online medical education company that helps healthcare professionals and laypeople understand medical topics clearly. Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset. Dr. Andrew Huberman is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award in 2017, which is given to the scientist making the largest discoveries in the study of vision. His lab’s most recent work focuses on the influence of vision and respiration on human performance and brain states such as fear and courage. Work from the Huberman Laboratory at Stanford University School of Medicine has been published in top journals including Nature, Science, and Cell and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets. This episode is brought to you by Rupa Health, ButcherBox, and Mitopure. You can check out a free, live demo with a Q&A or create an account at If you sign up at, ButcherBox will give you 2lbs of ground beef free for one whole year. Get 10% off at and use code DRHYMAN10 at checkout. Full-length episodes of these interviews can be found here:Dr. Roger SeheultDhru PurohitDr. Andrew Huberman

What's Causing Your IBS And How To Heal Your Gut

Ep. 600
This episode is sponsored by InsideTracker and Athletic Greens.Believe it or not, the surface area of your small intestine, which is where your food is absorbed, is the size of a tennis court. Your small intestine is also the home of your gut-immune system, which accounts for about 60 percent of your total immune system. The lining of this sophisticated system is just one cell layer away from a toxic sewer where all of the bacteria and undigested food particles live in your gut. If that lining breaks down—from stress; too many antibiotics or anti-inflammatory drugs like aspirin or ibuprofen; steroids; intestinal infections; a low-fiber, high-sugar diet; alcohol; and more—your immune system will be exposed to foreign particles from food, bacteria, and other microbes. This, in turn, creates havoc that can lead to an irritable bowel and other system-wide problems including allergies, arthritis, and autoimmune and mood disorders.In today’s episode of a new series called Health Bites, I discuss how to heal irritable bowel syndrome (IBS) and upregulate your gut health, which is at the forefront of Americans’ most common health complaints.This episode is sponsored by InsideTracker and Athletic Greens.InsideTracker is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting are more details from the episode (audio version / Apple Subscriber version):What is irritable bowel syndrome? (4:05 / 1:12)Symptoms of IBS (4:30 / 1:35) Causes of IBS (4:54 / 2:00) Identifying food allergies as the potential cause of IBS (8:00 / 5:11) How gut imbalance leads to IBS (9:36 /  6:44)Diagnostic testing to access gut health (12:14 / 9:25) What is SIBO, how does it cause IBS, and how is it diagnosed? (15:20 / 12:29) Assessing if yeast overgrowth is causing your gut issues (15:58 / 13:05) Treating yeast overgrowth and SIBO (16:40 / 13:50) Strategies for rebooting the gut and restoring optimal gut health (17:44 / 14:55)