The Doctor's Farmacy with Mark Hyman, M.D.


How Is Ozone Therapy Being Used To Treat COVID-19 in Europe? with Dr. Paolo Tordiglione

How Is Ozone Therapy Being Used To Treat COVID-19 in Europe? | This episode is brought to you by Simple Mills, Paleovalley, and Apeel

When we read the local headlines and stick to our own quarantine routines, it might be easy to forget that this virus is affecting the entire world. And as scary as that is, it also means we can collaborate with other countries to gain the best possible understanding of how to treat COVID-19. Since the spring, I’ve been reaching out to different doctors across the world to learn about their various COVID protocols. One of the most valuable contacts I’ve had, Dr. Paolo Tordiglione, has been seeing amazing results with ozone therapy and he is my guest on this episode of The Doctor’s Farmacy

Dr. Tordiglione is a Senior Consultant in Neuroanesthesia in the Neuro-ICU at Policlinico Umberto I University of Rome Sapienza, Italy. He is a specialist in pain medicine and an expert in ozone therapy. He is the former President of Doctors of the World Italy, founder of Physicians for Human Rights Italy, Vice President of the Academy of BioRegenerative Medicine, and a member of the Molecular Medicine Academy. He is currently developing a company called PLEYO, with the goal of scientifically improving the quality of human life, and has been researching ozone therapy since 2000.

This episode is brought to you by Simple Mills, Paleovalley, and Apeel.

Right now, Simple Mills is offering Doctor’s Farmacy listeners 20% off. Just head over to and use code HYMAN20 to try their Artisan Bread Mix and other amazing products to stock up for the holidays. 

Paleovalley is offering 15% off your entire first order. Just go to to check out all their clean Paleo products and take advantage of this deal.

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Here are more of the details from our interview:  

  • Where are we now in our understanding of COVID-19 and treatment for it? (7:32)

  • What is ozone therapy and what is its history of use? (13:41)

  • The rationale for using ozone therapy to treat COVID-19 (20:42)

  • Various methods of ozone therapy and how Dr. Tordiglione uses ozone therapy in the treatment of COVID-19 patients (24:15)

  • Dr. Tordiglione’s research using ozone therapy in women undergoing chemotherapy for breast cancer (34:46)

  • Case reports, studies, and clinical trials from around the world looking at ozone therapy in the treatment of COVID-19 (37:39)

  • Preliminary results from Dr. Tordiglione’s study of patient outcomes from ozone therapy in the treatment of COVID-19 (43:40)

  • How the FDA’s ruling on inhaled ozone in the ‘90s has blocked the use of ozone therapy in the United States (52:00)

  • My personal healing experience with ozone therapy (55:20)

  • Adjunctive nutritional and supplemental therapy for COVID-19 (1:00:08)


Learn more about Dr. Tordiglione at

Find his study, “Ozone as Adjuvant Support in the Treatment of COVID19: A Preliminary Report of Probiozovid Trial” here:

Additional research:

Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora (PROBIOZOVID)

Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported

Potential Role of Oxygen–Ozone Therapy in Treatment of COVID-19 Pneumonia

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