The Doctor's Farmacy with Mark Hyman, M.D.


Do You Have To Eat A Ketogenic Diet All Of The Time To Get Its Benefits? with Mark Sisson

The ketogenic diet has gained a lot of popularity in the past couple of years. If you’re not quite sure what it is, why it could be beneficial, or you’re well-acquainted with it and just want to learn more, this episode is for you. The ketogenic diet, or keto as it’s called, is a high-fat low carbohydrate diet. While some people take this to mean loads of conventionally raised meat and dairy, the true (and beneficial version) means lots of beneficial fats from things like avocados, nuts and seeds, and coconut; high-quality protein from clean sources like grass-fed meat and pasture-raised eggs; and plenty of non-starchy vegetables. 

To hash out more of the details about keto and how it can support good health, I was excited to talk with my friend and one of the leading voices in the Paleo/Primal and keto movements, Mark Sisson. Mark is the founder of the popular daily health blog, Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint.

This episode is sponsored by Joovv, chili, and my Sleep Master Class.

I recently discovered Joovv, a red light therapy device. Red light therapy is a super gentle non-invasive treatment where a device with medical-grade LEDs delivers concentrated light to your skin. It actually helps your cells produce collagen so it improves skin tone and complexion, diminishes signs of aging like wrinkles, and speeds the healing of wounds and scars. Check out the Joovv products at and use the code FARMACY at checkout.

One of the easiest and most effective ways to get better sleep every single night is through temperature regulation, which is why I was so relieved to discover the transformative products from Chili. The chiliPAD and OOLER system are two really cool gadgets that fit over the top of your mattress and use water to control the temperature of your bed - which helps lower your internal temperature and trigger deep relaxing sleep. Right now chili is offering my audience a really great deal. Get 25% off the chiliPAD with code hyman25 or 15% off OOLER with code hyman15, just go to

In this modern world we place too much value on staying busy and deprioritizing sleep, which is why I have created my first ever Master Class. It guides you through the most important steps to getting better sleep, starting today. To learn more about the Sleep Master Class, head over to

Here are more of the details from our interview: 

  • Mark’s wake-up call to change how he ate and exercised at 28 years old (5:42)

  • Tenets of the Primal Blueprint (13:50)

  • Reversing the aging process through metabolic flexibility (19:36)

  • What is a ketogenic diet? (24:37)

  • How long does it take to adapt to the ketogenic diet and why do people get the “keto flu”? (33:15)

  • Can you eat too much on the ketogenic diet? (35:53)

  • The way to know if you’re doing a ketogenic diet properly (39:28)

  • Weightlifting and the importance of muscle, especially as you age (41:12)

  • Why burning fat is better than burning sugar for longevity (44:21)

  • Do you have to be “keto” all of the time to get the benefits of a ketogenic diet? (53:02)

Find Mark online at and follow him on Facebook @marksdailyapple, on Instagram @marksdailyapple, and on Twitter @Mark_Sisson

Get Mark’s latest book Keto for Life at

More Episodes


How To Overcome Sugar Addiction with Keegan Allen and Tom Hopper

How To Overcome Sugar Addiction with Keegan Allen and Tom Hopper | This episode is brought to you by ButcherBox and chiliI can’t tell you how many times I’ve heard someone say they wish they had more willpower to be able to quit sugar. But here’s the thing: it’s an actual physical addiction and the food industry strives to get us hooked on sugar. So, it’s not about willpower, it’s about biochemistry. The great news is that we can reset our biochemistry and those sugar cravings and take back our health. The more you avoid sugar and refined carbohydrates (which just turn into sugar in your body) the more your body recognizes the natural sweetness in healthy foods like blueberries or even a red bell pepper.My guests on this episode of The Doctor’s Farmacy, Keegan Allen and Tom Hopper, have both been through the sugar struggle, and they’re here to share their inspiring stories of overcoming the addiction to discover their most vibrant health.Keegan is an American actor, musician, photographer, and author. He’s known for his main role as Toby Cavanaugh on the Freeform series Pretty Little Liars. Allen's passion in his younger years tended towards photography, cinematography, and other roles behind the camera. Tom is an English actor. He has appeared as Sir Percival in Merlin, Billy Bones in Black Sails, Dickon Tarly in Game of Thrones, and Luther Hargreeves in Netflix’s new show The Umbrella Academy.This episode is brought to you by ButcherBox and chili.ButcherBox makes it super easy to get humanely raised meat that you can trust by delivering it right to your doorstep. ButcherBox is committed to humanely raised animals that are never given antibiotics or added hormones and since they take out the middleman you get extra savings. ButcherBox is now gradually welcoming new customers due to increased demand, but only if you’re on the waitlist! So reserve your spot today at, and you’ll get an email when they’re ready to take your order.With the summer heat creeping up this is the perfect time to improve your sleep with a cooler bed and support your overall wellness routine at the same time. Right now, chili is celebrating Christmas in July with the gift of 20% off any sleep system. Just go to and enter code HYMAN20 at checkout to get 20% off any chili sleep system until July 8th.Here are more of the details from our interview:The health scare that led Tom to cut out sugar and start to view food as medicine (3:58)Keegan’s health journey from being pre-diabetic to understanding that his diet was making him unwell (12:42)Lactose intolerance, infertility, and sugar (17:10)Food labeling and ingredient lists (25:56)The first step to take to improve your diet (32:43)The science of sugar and how sugar affects your immune system (35:53)Keegan’s experience resetting his diet and improving his health (43:43)Sugar, cancer, and the ketogenic diet (48:07)The 10-Reset available at or (51:26)Worsening health metrics among children (58:08)Follow Keegan Allen on Instagram @keeoone and on Twitter @KeeganAllenFollow Tom Hopper on Instagram @tom.hopperhops and on Twitter @Tomhopperhops

Is Brain Fog Caused By Your Microbiome? with Dr. Todd LePine

Is Brain Fog Caused By Your Microbiome? with Dr. Todd LePine | This episode is brought to you by AirDoctor Many of us have experienced an inability to sustain our train of thought, difficulty focusing, the feeling like you’re living in a daze, and other types of brain fog. So what causes brain fog? The key insight is that your brain is not just some object sitting on the top of your shoulders. Your brain is an organ that’s connected to everything else happening in your body. And fixing your brain starts with fixing your body. When it comes to brain fog, that usually means attending to your gut health.In this episode, Dr. Hyman sits down with Dr. Todd LePine to discuss the Functional Medicine approach to treating brain fog. They explain why brain fog is so inextricably linked to gut health and how brain fog can be triggered by a range of things from diet to allergies to autoimmune conditions to environmental toxins and much, much more.Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders and the neurobiology of mood and cognitive disorders. Dr. LePine teaches around the world, and has given lectures to doctors and patients at American College for Advancement in Medicine (ACAM), Age Management Medicine Group (AMMG), the University of Miami Integrative Medicine Conference, The Kripalu Center in Lenox, MA, and is on the faculty for American Academy of Anti-Aging Medicine (A4M). Dr. LePine is the head of the Scientific Advisory Board for Designs for Health and a consultant for Diagnostic Solutions Laboratory. He enjoys skiing, kayaking, hiking, camping and golfing in the beautiful Berkshires, and is a fitness enthusiast.This episode is sponsored by AirDoctor. We need clean air not only to live but to create vibrant health and protect ourselves and loved ones from toxin exposure and disease. Learn more about the AirDoctor Professional Air Purifier system at a special price at this episode, Dr. Hyman and Dr. LePine discuss:Brain fog is not a condition, it is a symptomGut fermentation is as a common cause of brain fogHow gluten, dairy, diet, food sensitivities, and gut dysbiosis can lead to brain fogOther reasons for brain fog including infections, tick infections, allergies, environmental toxins, autoimmune conditions, and moreThe relationship between the immune system and the gutHow Dr. LePine worked with and treated a patient experiencing brain fogFor more information visit Resources:Supporting Our Innate Resilience Wrong Gut Bugs Can Make You Fat and Sick (and How to Fix Them) Healthy is an Inside Job a Better Immune System for Lifelong Health and Vitality New Approach to Autoimmune Disease Your Broken Brain + Lots More: 10 Takeaways from My Most-Asked Questions Broken Brain Podcast – My Personal Journey to Fixing My Brain with Dr. Mark Hyman