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Nature Podcast
Squid-inspired pills squirt drugs straight into your gut
Inspired by squids’ ability to shoot ink, a team of researchers have developed swallowable devices that can deliver tiny jets of drugs directly into the gut lining, circumventing the need for needles. Previous studies have shown that most people prefer to take medication in pill form, rather than as an injection, but many drugs are degraded as they pass through the digestive system. The team’s new swallowable devices overcome this issue, and deliver drugs directly to where they need to be. So far, this approach has shown efficacy in animal models, but more work needs to be done to ensure their safety in humans.
Research Article: Arrick et al.
10:50 Research Highlights
The largest ‘terror bird’ fossil ever found, and a simple solution to help prevent premature births.
Research Highlight: Huge carnivorous ‘terror bird’ rivalled the giant panda in size
Research Highlight: Reducing pregnancy risk could be as easy as chewing gum
12:52 A milder way to break down ‘forever chemicals’.
Two papers describe how light-activated catalysts could be used to break down toxic ‘forever chemicals’, hinting at a new way to clean up pollution caused by these persistent compounds. Forever chemicals contain multiple carbon-fluorine bonds that give them useful physical properties, but these bonds are some of the strongest in organic chemistry, making these compounds energetically difficult to break down. The new, light-based methods demonstrate low-energy ways to sever these bonds, a milestone that could make forever chemicals less permanent.
Research Article: Zhang et al.
Research Article: Liu et al.
News and Views: Catalysts degrade forever chemicals with visible light
21:04 Briefing Chat
Analysis of far-side soil highlights the Moon’s turbulent past, and how CRISPR can help make sweeter tomatoes.
Nature: First rocks returned from Moon’s far side reveal ancient volcanic activity
CNN: Findings from the first lunar far side samples raise new questions about the moon’s history
Nature: CRISPR builds a big tomato that’s actually sweet
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Audio long read: Is the peptide craze backed by science? The promise behind the hype
16:41|Peptides — short chains of amino acids — have become huge online. The popularity of these molecules has skyrocketed and they are now the latest cure-all trend on social media.But what does the science say about their effectiveness? Animal research suggests that that some of these experimental peptides hold promise, but evidence they work in people is lacking.This is an audio version of our Feature: Is the peptide craze backed by science? The promise behind the hype
Briefing Chat: What tickling a chimpanzee can tell us about the evolution of speech
11:30|Nature staff discuss how apes share a rhythm of laughter, and how AI use may degrade skills in medicine and computer science.00:32 Early evidence suggests that AI use causes skills to atrophyNature: Is AI ruining our skills? Early results are in — and they’re not good06:42 Humans and chimps share a laughNature: Oo oo, ha ha: why humans and great apes giggle alike when tickledSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Medical records could be revealed by AI training-data vulnerability
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Briefing Chat: Testosterone and sperm may get a boost from obesity drugs
12:16|Nature staff discuss preliminary data on the effects of GLP-1 drugs on male fertility plus a two-year trial of a brain-computer interface.00:18 Brain-computer interface makes a life-changing impactNature: At-home brain implant gives man with motor neuron disease his daily life back05:39 The possible benefits of obesity drugs on testosteroneNature: The latest benefit of obesity drugs: boosting testosterone and sperm qualitySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.DNA from hunter-gatherer teeth reveals secrets of ancient plague
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Briefing Chat: The epic journey of Stonehenge’s central stone
11:20|In this episode:00:37 Evidence that Stonehenge's Altar Stone travelled by glacierBBC Science Focus: We may have just cracked one of Stonehenge's greatest mysteries05:44 Fossilized faeces reveal DNA from ancient ecosystemNature: Ancient ground squirrels feasted on carcasses like ‘zombies of the Pleistocene’Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Newly-discovered whale graveyard dates back millions of years
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Briefing chat: Spinosaurs with salt glands could have lived in marine environments
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