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Minding Memory
Exploring Research on Alzheimer’s Disease and other Types of Dementia
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1. Neighborhood Income and Cognitive Health
26:42||Season 5, Ep. 1Welcome back to Minding Memory! In today’s episode, Lauren & Matt speak with Dr. Laura Zahodne – a professor of psychology at the University of Michigan and an affiliate of the Institute for Social Research. She's a clinical neuropsychologist by training and studies how psychosocial experiences shape late life, cognitive health, and risk of neurodegenerative disease. Also, a new member of our CAPRA leadership team! In this episode, we’ll get to know Laura a little better and talk with her about one of her research studies, the Neighborhood Racial Income Inequality in Cognitive Health, which looks at the association between racial income differences and a variety of cognitive measures. The transcript for this episode can be found here. Links of Interest: Laura Zahodne Faculty Profile Introduction to the Michigan Cognitive Aging Project Articles Referenced in Podcast: Zahodne LB, Sol K, Scambray K, Lee JH, Palms JD, Morris EP, Taylor L, Ku V, Lesniak M, Melendez R, Elliott MR, Clarke PJ. Neighborhood racial income inequality and cognitive health. Alzheimers Dement. 2024 Aug;20(8):5338-5346. doi: 10.1002/alz.13911. Epub 2024 Jun 27. PMID: 38934219; PMCID: PMC11350017. Hu Y, Elliott MR, Meier HCS, Chen L, Walters ME, Sol K, Zahodne LB. The impact of census-tract level mortgage discrimination on cognitive function: accounting for measurement instability in small-area data via joint modeling. Am J Epidemiol. 2025 Nov 4;194(11):3258-3266. doi: 10.1093/aje/kwaf131. PMID: 40522478; PMCID: PMC12634109. You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
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10. An Introduction to the Guiding an Improved Dementia Experience (GUIDE) Model of Care
32:34||Season 4, Ep. 10In today’s episode, Matt and Lauren discuss the new CMS GUIDE model for dementia care with Dr. Brystana Kaufman, MSPH, PhD – a health services researcher at the Duke-Margolis Institute for Health Policy at Duke University. The GUIDE model aims to improve the quality of life for people living with dementia by reducing strain on caregivers and enabling individuals to remain in their homes. Brystana talks with the Minding Memory team about a spectrum of topics as related to the GUIDE model including, what motivated CMS to develop and implement the model; what defines a serious illness; how the model supports caregivers; and what an organization needs to have in terms of services in order to participate in the implementation of the GUIDE model. Dr. Kaufman is the co-author of an article in the Journal of the American Geriatrics Society titled “GUIDE Dementia Model: Opportunities for Serious Illness Care” which provides additional insight into the model. Episode Transcript Brystana Kaufman, PhD, MSPH Faculty Profile Article referenced in this episode: Kaufman BG, Grant M. GUIDE dementia model: Opportunities for serious illness care. J Am Geriatr Soc. 2024 Jun;72(6):1935-1938. doi: 10.1111/jgs.18787. Epub 2024 Feb 5. PMID: 38315037. Additional Resources: Guiding an Improved Dementia Experience (GUIDE) Model Health and Aging Policy Fellows You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
9. Exposure to a Natural Disaster and Long-term Cognition
46:41||Season 4, Ep. 9In this episode, Matt and Lauren speak with Drs. Elizabeth Frankenberg at the University of North Carolina at Chapel Hill and Duncan Thomas at Duke University about their research which focuses on understanding how survival and physical health evolve after exposure to large scale shocks like the 2004 Indian Ocean Earthquake and Tsunami. They will specifically speak about the STAR Study and what they’re learning about long-term effects on cognitive outcomes. Faculty Profiles: Elizabeth Frankenberg, PhD Duncan Thomas, PhD Resources from the Episode: Study of the Tsunami Aftermath and Recovery (STAR) STAR Study Design and Results The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
Identifying Cognitive Difficulty among Middle Eastern and North African (MENA) Americans
32:23|In this episode, Matt and Lauren speak with Dr. Tiffany Kindratt whose research focuses on examining health outcomes among the Middle Eastern and North African (MENA) population, a group that was – until recently – categorized as “white” by the US government despite. Evidence showing their health and lived experiences are different. We’ll get into a recent American Journal of Public Health article authored by Dr. Kindratt that that examines how cognitive difficulties differ among the MENA population when compared with other racial and ethnic categories. Faculty Profile: Tiffany Kindratt, PhD, MPH Health Survey Research (HSR) Lab @ University of Texas at Arlington American Community Survey (ACS) AJPH Article: Kindratt TB, Smith A. Cognitive Difficulty in Middle Eastern and North African Adults Living in the United States Compared With Other Racial and Ethnic Categories, 2017-2021. Am J Public Health. 2024 Nov;114(11):1265-1274. doi: 10.2105/AJPH.2024.307803. PMID: 39357001; PMCID: PMC11447784. The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
7. Understanding Dementia Risk Factors with Helen C. Kales, MD
49:21||Season 4, Ep. 7In this episode, Matt & Lauren have the unique opportunity to talk with Dr. Helen C. Kales, a geriatric psychiatrist and health services researcher who has participated in the previous Lancet Commissions on Dementia Prevention, Intervention and Care – including the most recent one released in 2024. Dr. Kales discusses how the commission puts together all the evidence to make recommendations that can play a crucial role in dementia prevention. Dr. Kales is the Chair of the Department of Psychiatry and Behavioral Sciences and Joe P. Tupin Professor of Psychiatry at the University of California at Davis and has dedicated much of her career to improving the lives of patients living with dementia. Helen C. Kales, MD Faculty Profile 2024 Lancet Commission: Dementia prevention, intervention, and care: 2024 report of the Lancet Standing Commission The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
6. The Link Between Hearing Loss and Cognitive Decline
39:47||Season 4, Ep. 6Hearing loss is one of the most common conditions of aging, affecting nearly two-thirds of older adults over the age of 70, but it’s not just a matter of diminished hearing. Hearing loss can contribute to poor psychosocial outcomes for patients including loneliness, depression, and social isolation. New research also shows that hearing loss is linked to a higher risk of cognitive decline and dementia. In fact, the 2024 Lancet Commission on Dementia Prevention, Intervention, and Care identified hearing loss as one of 14 modifiable risk factors for dementia. According to the commission, treating hearing loss could prevent up to 7% of dementia cases globally, making it one of the most impactful areas for potential prevention. This raises the question of whether use of hearing aids in people with hearing loss can reduce or mitigate this increased dementia risk. To help us understand these connections and the latest research in this area, we are joined today by Dr. Alison Huang, an epidemiologist and Senior Research Associate from the Johns Hopkins Cochlear Center for Hearing and Public Health. Her research studies the impact of sensory loss on cognitive and mental health in older adults. Dr. Huang was an author of the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study, a large, multicenter randomized controlled trial that tested whether treating hearing loss in older adults could help slow cognitive decline published in the Lancet. Alison Huang, PhD, MPH Link to article: Lin FR, Pike JR, Albert MS, Arnold M, Burgard S, Chisolm T, Couper D, Deal JA, Goman AM, Glynn NW, Gmelin T, Gravens-Mueller L, Hayden KM, Huang AR, Knopman D, Mitchell CM, Mosley T, Pankow JS, Reed NS, Sanchez V, Schrack JA, Windham BG, Coresh J; ACHIEVE Collaborative Research Group. Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. Lancet. 2023 Sep 2;402(10404):786-797. doi: 10.1016/S0140-6736(23)01406-X. Epub 2023 Jul 18. PMID: 37478886; PMCID: PMC10529382. The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.
5. Greenspace and Late-Life Cognitive Decline
34:20||Season 4, Ep. 5In this episode Matt and Lauren will speak with Dr. Marcia Pescador Jimenez, an Assistant Professor in the Department of Epidemiology at Boston University whose research focuses on understanding the relationship between exposure to green space and health outcomes (including hypertension and cognitive measures). Emerging research has shown that midlife risk factors may delay or even prevent the onset of dementia later in life - among these include physical activity and social interaction. It’s not a stretch to imagine how a person’s environment may impact behaviors such as physical activity. For instance, there are places that lack sidewalks and parks that make exercising exceedingly difficult. Among environmental epidemiologists, there is growing interest in understanding how the built and natural environment influence our behaviors that, in turn, influence our health. We encourage you to listen to this episode while on a walk outside! Dr. Marcia Pescador Jimenez Faculty Profile Article Referenced in Podcast: Pescador Jimenez M, Wagner M, Laden F, Hart JE, Grodstein F, James P. Midlife Residential Greenness and Late-Life Cognitive Decline among Nurses' Health Study Participants. Environ Health Perspect. 2024 Jul;132(7):77003. doi: 10.1289/EHP13588. Epub 2024 Jul 17. PMID: 39016600; PMCID: PMC11253812. Nurses’ Health Study The social engagement scale that was referenced in the podcast is called the “Berkman-Syme Social Network Index”The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts.