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Custom mRNA Modification
During the past years, the mRNA-based therapy which is founded on the induction of the transient translation with the cell's ribosomes of fully functional proteins without integration into the host genome has become a potential drug for cancer immunotherapy and prophylactic vaccines. Compared with conventional gene therapy and protein substitution strategies, in vitro synthetic (IVT) mRNA has several advantages. However, the molecule's instability and immunogenicity caused by the lack of a cap structure at the 5' end and a long sequence of polyadenylate residue (poly(A) tail) at the 3' end hamper the development of mRNA therapeutics for many years. As the cap structure and the poly(A) tail of the mRNA greatly enhance the stability of natural mRNA, synthetically produced mRNA can also be modified to contain these structures. Using these modifications, the stability of synthetic mRNAs can be improved, immunogenicity can be reduced, and the translation efficiency can be increased.
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Whole transcriptome sequencing services for cancer
09:23|Cancer WTSmRNA SequencingSmall RNA SequencingCircRNA SequencingLncRNA SequencingExosome RNA SequencingUltra Low Input RNA SequencingRNA Sequencing for Formalin-Fixed Paraffin-Embedded (FFPE) TissueWhole transcriptome sequencing for cancer
09:23|Advances in massive parallel DNA sequencing technologies have enabled RNA-seq by sequencing of cDNA. RNA-seq is a revolutionary tool with better resolution and higher reproducibility that offers many advantages over the traditional microarray technologies. RNA-seq can be used to extend our knowledge of alternative splicing events, novel genes and transcripts, and fusion transcripts. RNA-seq can also help to understand molecular mechanisms and then it tells about signaling pathways which controls embryonic development. The transcriptome data give researchers a good place to start searching for a newly found gene's function.Cancer whole transcriptome sequencing services
09:23|RNA-seq is a revolutionary tool with better resolution and higher reproducibility that offers many advantages over the traditional microarray technologies. RNA-seq can be used to extend our knowledge of alternative splicing events, novel genes and transcripts, and fusion transcripts. RNA-seq can also help to understand molecular mechanisms and then it tells about signaling pathways which controls embryonic development. The transcriptome data give researchers a good place to start searching for a newly found gene's function.Transcriptome sequencing for cancer
09:23|The transcriptome is the entire set of RNA transcripts in a given cell for a specific developmental stage or physiological condition. RNA is a polymeric molecule implicated in various biological processes, such as the coding, decoding, regulation, and expression of genes. RNA molecules include mRNAs, long non-coding RNA (lncRNAs), circular RNA (circRNAs), microRNA (miRNA), message RNA (mRNA), transfer (tRNA) and ribosomal ribonucleic acid (rRNA).RNA services for cancer
09:23|RNA-seq is an important tool for interpreting the functional elements of the genome as well as for understanding the underlying mechanisms of diverse diseases, especially cancers.WTS services for cancer
09:23|The transcriptome is the entire set of RNA transcripts in a given cell for a specific developmental stage or physiological condition. RNA is a polymeric molecule implicated in various biological processes, such as the coding, decoding, regulation, and expression of genes. RNA molecules include mRNAs, long non-coding RNA (lncRNAs), circular RNA (circRNAs), microRNA (miRNA), message RNA (mRNA), transfer (tRNA) and ribosomal ribonucleic acid (rRNA).WTS for cancer
09:23|Whole transcriptome sequencing (WTS) is used to reveal the presence and quantity of RNA, in a biological sample under specific conditions.RNA-seq for cancer
09:23|Whole transcriptome analysis has been an important tool in solving biological issues and understanding the molecular mechanisms of many diseases including human cancers.Cancer WTS services
09:23|Whole transcriptome analysis has been an important tool in solving biological issues and understanding the molecular mechanisms of many diseases including human cancers. Whole transcriptome sequencing (WTS) is used to reveal the presence and quantity of RNA, in a biological sample under specific conditions.