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13. GLP-1s on Trial! Ozempic, Metabolic Health & What You Really Should Know | LifeLONG
59:49||Season 1, Ep. 13Want to join the show live and just hang out with Ethan and Co.?Zoom isn’t just Q&A. It’s your all-access pass to LifeLONG: see some pre-show prep, stick around after we stop recording, and connect with the crew and other viewers. Get your personalized link here:👉 https://us06web.zoom.us/meeting/register/jrw2LEWiSwy2fXG9ytocNADave Knapp, founder of On The Pen, joins Ethan Suplee on LifeLONG for a wide-ranging conversation about the latest developments in GLP-1 medications, metabolic health, Type 2 diabetes, and obesity treatment. https://www.onthepen.com/aboutKnapp has become one of the most trusted independent voices covering this fast-moving space, blending research, patient experience, and straight-talk analysis to help people understand how drugs like Ozempic, Wegovy, and Mounjaro actually work. From the surprising origin story of GLP-1 in Gila monster venom to today’s blockbuster prescriptions and new therapies on the horizon, we break down what’s real, what’s hype, and what these medications mean for long-term health.Timing felt right. It’s the Monday after the Super Bowl. The snacks are gone, the leftovers are questionable, and half the country is quietly promising to “get it together.” Perfect moment to talk metabolism, habits, and what sustainable change actually looks like.We cover the newest GLP-1 headlines, how these drugs affect appetite and blood sugar, common misconceptions, and how to think about obesity as a chronic, relapsing condition rather than a willpower problem.Watch live on YouTube — or register above to come backstage, participate, and ask questions in real time. Subscribe for more conversations on strength, longevity, and lifelong health.(00:00) Intro: The Super Bowl Hangover (00:45) Novo Nordisk Sues Hims: The First Patent Lawsuit (05:03) Did Hims Want This Fight? FDA Defiance (09:27) The Marketing Problem: Being "First to Market" (13:00) "Project Trump," Price Wars, and the FDA Crackdown (17:05) The Science: Why Compounding Pills is Risky (20:57) The Debate: Pharma R&D Costs vs. Patient Access (26:08) Super Bowl Ads: Serena Williams & Obesity Stigma (31:02) Why Insurance Companies Deny Coverage (37:50) Q&A: Integrating Mental Health with GLP-1s (42:36) Q&A: What If the Meds Don't Work? (Non-Responders)(46:49) Q&A: Managing Stress & Diabetes (Trulicity to Mounjaro) (49:55) Q&A: De-Moralizing Meds—They Are Just Tools (56:08) Lightning Round with Dave Knapp (58:38) Daily Nudge: Bad Bunny & Outro
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12. Jesse Mulley on Skin Removal Surgery & Losing 290 lbs | LifeLONG Ethan Suplee
01:00:00||Season 1, Ep. 12Today’s guest is Jesse Mulley is a weight loss coach and creator behind @progressive.overhaul focused on building real, sustainable change without crash diets or misery.Jesse just finished round two of skin removal surgery after losing 290 pounds naturally. His arms and legs carried a heavy daily burden, with rashes, pain, movement restrictions, and the emotional weight of excess skin.For him, this wasn’t cosmetic. It was about comfort, mobility, and fully reclaiming his life. He made it happen through crowdsourcing, thanks to the community that has followed and supported his journey.
11. Ethan Benard on Losing Weight in Public | LifeLONG Ethan Suplee
01:01:15||Season 1, Ep. 11This episode of LifeLONG features Ethan Benard is a 26-year-old weight-loss creator from western Michigan documenting his journey from nearly 660 pounds toward sustainable health. He shares daily updates across Instagram, Facebook, TikTok, and YouTube, tracking meals, movement, and workouts in real time.His story gained wide attention after a viral post showing nearly 200 pounds lost, leading to a rapidly growing audience and collaborations with trainers and fitness brands. Ethan speaks candidly about the realities of losing weight in public, including the mental, emotional, and social challenges, while focusing on long-term health through balanced nutrition and strength training.
10. Let's talk Weight Cycling: GLP1s, Gym Mistakes, and the new Food Pyramid | LifeLONG Ethan Suplee
58:41||Season 1, Ep. 10This episode of LifeLONG features bodybuilding coach Dylan Guynn and tackles the intersection of muscle building, sustainable fat loss, and new public health developments. Ethan opens by criticizing the 2026 US government alcohol guidelines, which removed the specific numerical limits of one drink per day for women and two for men. The new guidance vaguely suggests drinking less if you can, a change Ethan argues benefits corporate lobbyists while obscuring the link between alcohol and cancer. The conversation then shifts to body composition, with Dylan explaining how a bodybuilding lifestyle, focused on muscle sparing rather than just weight loss, creates a more sustainable long-term health model compared to the extreme peaks and valleys of crash dieting.A significant portion of the discussion focuses on GLP-1 agonists like Ozempic and Wegovy. Dylan and Ethan explore the risks of muscle wasting on these medications due to low caloric intake and emphasize the necessity of high protein consumption and resistance training to maintain lean tissue. They discuss the phenomenon of diet fatigue, noting that even with appetite suppression, the nervous system accumulates stress that requires management through diet breaks or fatigue reduction strategies. Ethan expresses concern about patients cycling off these drugs and regaining weight as fat, potentially leading to a worse body composition over time. They also advocate for using GLP-1s as a tool to establish healthy habits, potentially allowing for lower maintenance doses rather than complete cessation .The episode also includes a reaction to a clip from strength coach Mike Boyle, who argues against the train to failure mentality, suggesting that consistency is far more effective than high-intensity workouts that leave you crippled. Dylan agrees, noting that while training to failure can increase muscle growth, it fills the fatigue bucket too quickly for most people to sustain long-term. Finally, the show touches on the flipped food pyramid, with both hosts supporting a protein-forward approach. The episode concludes with a Daily Nudge on persistence from Ralph Waldo Emerson, reminding listeners that strength is built by returning to the work day after day.
9. Did Ozempic Kill the New Year’s Resolution? | LifeLONG Ethan Suplee
56:48||Season 1, Ep. 9This week on LifeLONG, Ethan Suplee and Dr. Spencer Nadolsky investigate a strange phenomenon that hit fitness centers this January: the gyms were completely empty. We explore the conspiracy theory that the rise of GLP-1 agonists like Ozempic and Wegovy has finally killed the desperate New Year’s Resolution rush, allowing people to focus on their health year-round instead. Dr. Nadolsky breaks down the hard data behind these nuclear tools for weight loss, specifically addressing the terrifying headlines about muscle wasting. He reveals the real difference between Semaglutide, which can result in nearly 40% fat-free mass loss, and Tirzepatide (Mounjaro), which averages closer to 25%, while explaining why DEXA scans often mistake fluid loss for muscle loss.Beyond the medication, they dive deep into the psychology and physical reality of extreme weight loss. Ethan and Dr. Nadolsky debate the controversial question of whether obesity is truly a choice or a result of genetics clashing with our modern food environment, with Ethan sharing his perspective on how he didn't choose obesity but had to actively choose his recovery. Ethan also gets incredibly vulnerable about the disaster of his loose skin removal surgeries, sharing graphic details about the recovery process that most influencers won't tell you, including the mental toll of being bedridden for weeks. Finally, we discuss why 2026 might be the Year of Fiber, why Dr. Nadolsky ranks it above protein for GLP-1 users, and the specific strategies you need to build muscle while on these medications.
8. Ethan Suplee: Why "Stay Positive" Is Actually Dangerous Advice | LifeLONG Ethan Suplee
55:13||Season 1, Ep. 8Does "staying positive" actually make you feel worse? As we head into the New Year, the pressure to be optimistic and set massive goals can be overwhelming. In this episode of LifeLONG, Ethan sits down with educator and viral content creator Dr. Zac Bauermaster to dismantle the myth of "good vibes only" and explore a more sustainable approach to personal growth.They kick things off by tackling the concept of "Toxic Positivity," the idea that forcing happiness can actually alienate us from our true feelings and the people around us. Ethan shares why overly chipper advice sometimes makes his skin crawl, while Zach explains how true empathy means sitting with someone in their struggle rather than trying to fix it with a fake smile. If you’ve ever felt guilty for not being happy 24/7, this honest conversation about meeting people where they are is the reality check you need.Instead of setting rigid New Year's resolutions that are destined to fail by February, Zac introduces the One Word method. Whether it’s "Discipline," "Serve," or "Declutter," choosing a single guiding theme for your year can be more powerful than a checklist of impossible tasks. They discuss how this simple mindset shift helps build consistency without the shame spiral that comes from missed targets.Ethan and Zac also dive into practical strategies for overcoming analysis paralysis. Drawing on wisdom from a Rich Roll clip, they talk about the danger of overthinking lifestyle changes. Zac shares a brilliant analogy involving his son’s drone: sometimes the goal isn't to fly high immediately, but just to get it off the ground and hover. Whether you are trying to write a book, start a weight loss journey, or just get off the couch, Zac talks about how setting simple timers can snap you out of hesitation and into action.Finally, they get into the nitty-gritty of health debates, including a candid chat about nicotine lozenges, the confusing science around salt and sodium intake, and the macronutrients of happiness (Enjoyment, Satisfaction, and Purpose). If you are looking for a way to start 2026 with clarity, purpose, and a little less fake positivity, this episode is for you.
7. The Gen X Advantage: Why Your 40s Are the BEST Time to Get Fit | LifeLONG Ethan Suplee
58:15||Season 1, Ep. 7Can a simple act of kindness actually add years to your life? In this episode of LifeLONG, Ethan Suplee sits down with Lisa DePasquale, author of The Gen X Handbook for Middle Age, to reveal why middle age is actually the most powerful window for a radical life transformation. While many believe their best years are behind them, Ethan and Lisa discuss how the mental fortitude and maturity gained over four decades provide the exact tools needed to make weight loss and health habits finally stick. Lisa shares the details of her incredible journey losing 170 pounds, moving from the tombstone mindset of her 40s to a life defined by strength and success. By shifting from impossible goals to sustainable systems, she proves that aging is not a hurdle, but a strategic advantage for anyone seeking long-term longevity.The conversation dives deep into the science of kindness, exploring the biological phenomenon known as the "helper’s high." Scientific research shows that performing small, prosocial acts triggers a dopamine hit that significantly boosts the giver’s wellbeing and reduces the stress that often leads to health spirals. Whether it is reframing hard work as a "kindness" to your future self or engaging in micro-interactions at the grocery store to combat seasonal depression, this episode explains why your social connections are just as vital to your health as your macros. We also tackle practical strategies for navigating high-stress periods like the holidays, moving from a mindset of punishment and binging toward one of moderation and recovery.If you have been searching for 2025 weight loss tips or a wellness mindset that survives the middle age spread, this episode provides the roadmap. From the Great Boomer Wealth Transfer to the unique resilience of Gen Xers, Ethan and Lisa break down how to stop the punishment cycle and start building a life you actually enjoy. Learn how to use your past victories to spiral up and discover why health is truly a lifelong journey that is built, not born. Join the conversation as we explore how maturity, accountability, and kindness create the ultimate foundation for healthy aging and human fulfillment.Lisa's book is available here!