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17. #17 How the $101M XPRIZE will reverse aging by 20 years | Jamie Justice
01:50:20||Ep. 17Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.We discuss:* Why Peter Diamandis pushed for more ambitious goals* How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.* The role of biomarkers in measuring aging* Why they chose to measure actual restoration rather than just preventing decline* The challenges and opportunities in aging clinical trials* Her vision for an integrated, multi-generational society that values aging populations🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/CHAPTERS:00:00 Introduction03:00 background21:30 XPRIZE sculpted by experience25:20 Collaborating with the entrant teams29:00 Why muscle, mind and immune functions as targets36:30 What if no one wins in 7-years?41:05 Investors attracted45:01 Does this give us increased longevity?51:05 What kind of approaches have been entered?01:00:30 AI01:09:20 Composit end-points01:13:10 TAME trial stuck because ...01:19:10 Biomarkers of aging01:26:50 AI and Biomarkers01:29:02 The longbio track (be lucky)01:36:20 Optimism about what?01:41:00 3 book you have to read
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16. #16 Critical health signals your doctor is overlooking | David Luu
01:52:41||Ep. 16A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future belongs to prevention rather than treatment. Plus, discover the vital link between community, lifestyle, and longevity, and why creating modern "blue zones" might be key to living longer, healthier lives.🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/CHAPTERS00:00 Introduction 02:33 A Family Legacy in Medicine 10:41 From Heart Surgeon to Tech Innovator with JuiSci and Hearty 13:47 Building AI-Powered Medical Platforms 21:33 The Heart Fund: Surgery for Those in Need 35:06 The Role of AI in Healthcare 45:22 Creating Longevity Docs Community 01:07:13 Hidden Cardiovascular Risk Factors 01:10:38 The Lp(a) Test Everyone Should Know About01:18:50 Why Call it ”Longevity Docs” When We Have No Approved Aging Interventions? 01:28:14 Different Levels of Longevity Interventions 01:38:42 Risk vs. Reward in Preventive Medicine 01:43:30 Building Modern Blue Zones 01:47:11 The Future of Medicine 01:52:07 Connecting with David15. #15 Fifty years of fighting death | James Strole
01:41:56||Season 1, Ep. 15🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/Meet one of the true legends of the longevity space, James Strole, the visionary founder of RAADfest who embodies relentless optimism and dedication to advancing the frontiers of longevity and human potential. His passion for creating a world where individuals can live longer, healthier lives shines through in every aspect of RAADfest, inspiring countless people to embrace the possibilities of radical life extension.We will learn about RAADfest and the history of the longevity movement. We will also explore Strole's philosophy of immortality.- CHAPTERS --00:00 introduction to James Strole04:20 RAADfest is the largest longevity event in the world11:50 personal awakening and the early days of the longevity movement22:00 longevity as a counter-culture23:00 death-program vs superlongevity26:30 1960s spreading the word and rebirthing31.00 people unlimited and science of superlongevity33:00 a holistic approach science of mind-set34:00 alternative medicine not always taken seriously37:40 the immortality mindset38:50 aged by culture44:20 optimism vs pessimism46:10 optimism about longevity science?58:50 death-program runs deep01:03:30 Ray Kurzweil's optimistic prognosis01:11:00 social consequences of longevity01:12:30 cryonics is an ambulance to the future01:15:05 imaginary mortality01:18:18 immortality via children01:19:19 is superlongevity egoistic?01:23:10 handle the loss of near and dear as an immortalist01:37:50 advice on health and where to be in contact with People Unlimited and James Strole- 01:47:51||Ep. 14🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/-- IN THIS EPISODE --Nora Cavani, CEO of Alba Health, shares her journey from struggling with severe eczema and allergies to pioneering breakthrough solutions in children's gut health. After reversing her own chronic conditions through lifestyle changes, she learned how the first years of life critically shape our immune system, metabolism, and lifelong health through the gut microbiome.As the first company to collaborate with leading microbiome research institutions, Alba Health uses cutting-edge metagenomics technology to analyze children's gut bacteria and provide personalized recommendations. Cavani explains why modern factors like C-sections, antibiotics, and processed foods are leading to a concerning loss of essential gut bacteria in Western children - with many babies now lacking microbes crucial for immune development.Learn how the gut microbiome affects everything from common childhood ailments to chronic disease risk, why diversity in diet matters, and practical steps parents can take during the critical early window of their child's development. A vital conversation for parents, health optimizers, and anyone interested in preventing chronic disease through early intervention.-- CHAPTERS --00:00 Introduction to Nora Cavani05:08 Microbiome and child health07:16 Nora’s journey from Italy to Sweden10:43 Meeting the scientist and microbiologist Willem de Vos15:20 Laying the groundwork for Alba Health18:45 Gut microbiome is linked to afflictions in newborns19:29 The ecosystem of the gut microbiome21:00 The Ecosystem of the Gut Microbiome28:33 Gut-brain axis30:50 C-section and antibiotics35:10 Alba's testing methodology and insights41:38 Predicting health through microbiome analysis45:23 The best time to take the test54:20 Has Nora managed to get rid of her health issues?57:19 The role of diet diversity in gut health01:07:52 What can we still discover about the microbiome?01:10:05 The role of exercise, sleep and stress in adults01:12:40 Child health and longevity01:16:40 Nora’s personal longevity regimen and testing01:23:36 Oura’s investment i Alba Health01:28:18 Future of microbiome research01:32:28 Scientific consensus and controversy01:43:37 The future for Alba Health01:45:52 How to get in touch with Nora and Alba
13. #13 How to Invest in an Ageless Future - Sergey Jakimov
01:25:02||Ep. 13🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/🚀 Looking for LEVITY Merch? https://levity-7.creator-spring.com/Sergey Jakimov is a founding partner of LongeVC, a VC fund supporting early-stage biotech and longevity-focused founders who are changing the world.12. #12 Medical Freedom in the Caribbean - Niklas Anzinger
01:02:49||Ep. 12🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/Niklas Anzinger is the founder of Infinita VC based in the charter city of Prospera in Honduras. He is the co-founder of Vitalia, a longevity focused community. His fund Infinita focuses on a new trend of charter cities and other forms of alternative jurisdictions. He also hosts a podcast about how to accelerate the future by unblocking “stranded technologies”.11. #11 The Complete Guide to Cryopreservation
02:08:46||Ep. 11🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/When I first met Emil Kendziorra at the Longevity Biotech Fellowship retreat in Sweden, I found myself captivated by his ability to explain every aspect of cryopreservation for hours. His deep knowledge, combined with his remarkable skill in communicating complex ideas, made me realize this conversation needed to reach a broader audience.In this comprehensive episode, Emil, CEO of Tomorrow Bio, takes us through the fascinating world of cryopreservation, leaving no stone unturned. We explore:The science behind cryopreservation and how it differs from simple freezingThe history of cryonics and its evolution into modern cryopreservationStep-by-step details of the preservation processThe logistics of emergency response and stabilizationLong-term storage solutions and safety measuresThe challenges and possibilities of future revivalEthical considerations and philosophical implicationsThe current state of research and future developmentsPractical aspects of signing up and fundingCommon misconceptions and concernsWhether you're curious about cryopreservation as a backup plan for longevity or simply interested in understanding this fascinating field, this episode provides a comprehensive overview of what might be our best bridge to a longer-lived future.