ISTAART Voices

In this episode of ISTAART Voices, Dr. Sietske Sikkes and Dr. Mark Dubbelman reveal the complex challenges of pooling data from multiple Alzheimer's disease clinical trials. Their research highlights significant barriers in accessing and analyzing historical trial data, demonstrating the critical need for more open and streamlined scientific collaboration. This discussion underscores the importance of making clinical trial data more accessible to advance personalized medicine and understanding of Alzheimer's disease treatment responsiveness.Special thanks to ISTAART Ambassador Lucy Core for her contributions to the production of this episode of ISTAART Voices.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12485Dr. Mark A. Dubbelman: https://connects.catalyst.harvard.edu/Profiles/display/Person/213733Dr. Sietske A. M. Sikkes: https://research.vu.nl/en/persons/sietske-sikkesProfessional Interest Areas (PIAs): alz.org/ISTAARTPIAS Podcast CMEs: alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

In this episode, Dr. Sylvie Belleville talks through the latest results from a trial involving older adults experiencing mild cognitive impairment. This work emphasizes how targeted cognitive training and memory interventions could potentially slow the progression of mild cognitive impairment and may help sustain long-term cognitive function. The trial results offer compelling perspectives on non-pharmacological interventions for delaying the onset of dementia in individuals experiencing early cognitive changes.Special thanks to ISTAART Ambassador James Brady for his contributions to the production of this episode of ISTAART Voices.LinksShow page: alz.org/ISTAARTpodcastISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12626/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_SB&utm_id=ISTAARTVoicesTAARTVoices Dr. Sylvie Belleville: https://recherche.umontreal.ca/english/our-researchers/professors-directory/researcher/is/in14272/Podcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Stressful life events like divorce and widowhood can have profound effects on brain health. In this episode of ISTAART Voices, Dr. Avinash Chandra shares his research exploring how marital dissolution may contribute to increased amyloid pathology and memory decline. His study offers compelling insights into the intricate relationship between life stress, brain biology, and cognitive aging, paving new avenues for understanding dementia risk factors.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70032/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_AC&utm_id=ISTAARTVoices Dr. Avinash Chandra: https://www.qmul.ac.uk/wiph/people/profiles/chandra-avinash.htmlPodcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAICTau Tau Global Conference 2025: alz.org/tau Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

New anti-amyloid therapies are transforming the treatment landscape for Alzheimer's disease. In this episode of ISTAART Voices, Dr. Gregory Jicha and Dr. Peter Nelson compare emerging Alzheimer's treatments to biologics used in cancer and other diseases. Their insightful analysis highlights the significance of new disease-modifying therapies, further illustrating why choices and access to treatment are crucial for individuals living with Alzheimer's disease.Special thanks to ISTAART Ambassador Shloka Dhareshwar for her contributions to the production of this episode of ISTAART Voices.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12500?utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_GJPN&utm_id=ISTAARTVoicesGregory A. Jicha: https://medicine.uky.edu/users/gajich2Peter T. Nelson: https://medicine.uky.edu/users/pnels2Clinicans’ Resources: www.alz.org/ISTAARTcliniciansALZ-NET: https://www.alz-net.org/ Podcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Hearing loss increases the risk of developing dementia in later years. In this episode of ISTAART Voices, researchers Dr. Joshua Stevenson-Hoare and Dr. Kouki Tomida dissect the ways in which hearing loss may accelerate dementia progression. Through studies conducted in Germany and Japan, their works explore how early hearing difficulties and reduced conversation could signal future cognitive decline, offering compelling perspectives on early intervention and prevention strategies.Special thanks to ISTAART Ambassador Michelle Chiu for her contributions to the production of this episode of ISTAART Voices.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper 1: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12586/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_KT&utm_id=ISTAARTVoices Featured paper 2: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12624/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_JSH&utm_id=ISTAARTVoicesDr. Kouki Tomida: https://orcid.org/0000-0002-7397-8224 Dr. Joshua Stevenson-Hoare: https://www.dkfz.de/en/clinical-epidemiology-and-aging-research/our-team Podcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2025 (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

In this episode, we explore the complex relationship between Alzheimer's and Lewy body pathologies. Our guest Dr. Duygu Tosun, explains how cutting-edge research methods are helping uncover this complex interplay of brain pathologies, and why understanding each individual's unique profile will be crucial for developing more personalized treatments in the future.Special thanks to ISTAART Ambassador Yara Yakoub for her contributions to the production of this episode of ISTAART Voices.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13858?utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_DTT&utm_id=ISTAARTVoices Dr. Duygu Tosun-Turgut: https://radiology.ucsf.edu/people/duygu-tosun-turgut ISTAART Alliance of Women Alzheimer's Researchers Professional Interest Area: www.alz.org/AWAREPIA  Podcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® (AAIC®): alz.org/AAICAAIC Neuroscience Next: alz.org/neurosciencenext Alzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

In this episode, we speak with Dr. Mohammad Fili and Dr. Auriel Willette about the exciting applications of machine learning and brain imaging in the context of Alzheimer's disease and related dementias. They explain how combining emerging technologies with existing large datasets can uncover compelling patterns in the brain that distinguish those on a trajectory of cognitive decline from those who maintain or even improve their mental abilities as they age.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12595/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_Mohammad&utm_id=ISTAARTVoices  Dr. Mohammad Fili: https://ceat.okstate.edu/iem/people/mohammad-fili-faculty-profile.html Dr. Auriel Willette: https://ifh.rutgers.edu/faculty_staff/auriel-a-willette-ba-ms-phd/ Podcast CMEs: www.alz.org/ISTAARTpodcastCMEISTAART Ambassador Program: www.alz.org/ISTAARTambassadors Alzheimer's Association International Conference® (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.

Alzheimer's disease profoundly affects the LGBTQIA+ community, yet research remains limited. In this episode, we speak with Dr. Jace Flatt about the risks and disparities LGBTQIA+ older adults face regarding cognitive decline and dementia. We uncover the challenges they navigate and explore innovative approaches to engage them in research.LinksShow page: alz.org/ISTAARTpodcast ISTAART: alz.org/ISTAART Featured paper: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12477/utm_source=podcast&utm_medium=newsletter&utm_campaign=IVS1_JasonF&utm_id=ISTAARTVoicesDr. Jason D. Flatt: https://www.unlv.edu/people/jason-flatt ISTAART Diversity and Disparities Professional Interest Area: www.alz.org/DDisparitiesPIA Alzheimer's Association LGBTQ+ Community Resources for Dementia: www.alz.org/lgbtq Alzheimer's Association Help Line: www.alz.org/helpline Podcast CMEs: www.alz.org/ISTAARTpodcastCMEAlzheimer's Association International Conference® 2024 (AAIC®): alz.org/AAICAlzheimer's Association Scientific Meetings: alz.org/scientificmeetings Alzheimer's Association Journal Family: alz.org/journals Social: #ISTAART @ISTAART The views and opinions expressed in this podcast are solely those of the guests and do not necessarily reflect those of the Alzheimer's Association. The Alzheimer's Association does not endorse any external product or service. This podcast is for informational purposes and is not intended to provide medical advice, please consult your physician.