Evolution 2.0


Childhood Trauma Causes Cancer; Therapy and Relationships Heal

Eric Kuelker Ph.D. R.Psych. discusses reliable but little-known research linking cancer and heart disease to traumatic life events and stress. It turns out that psychotherapy and relationship repair reduces the chances of cancer and factors like marriage extend life more than medical treatments do. This may extend it down to the cellular level.Eric’s website ishttps://psychologicalinjuryindex.com/References:Hughes K, Bellis MA, Hardcastle KA, Sethi D, Butchart A, Mikton C, Jones L, Dunne MP. (2017) The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Health.Aug;2(8):e356-e366.https://pubmed.ncbi.nlm.nih.gov/29253477/Roberts AL, Huang T, Koenen KC, Kim Y, Kubzansky LD, Tworoger SS. (2019) Post-traumatic stress disorder is associated with increased risk of ovarian cancer: A prospective and retrospective longitudinal cohort study. Cancer Res. Oct 1;79(19): 5113-5120.https://pubmed.ncbi.nlm.nih.gov/31488422/Lu D, Sundström K, Sparén P, Fall K, Sjölander A, Dillner J, Helm NY, Adami HO, Valdimarsdóttir U, Fang F. (2016).Bereavement is associated with an increased risk of HPV infection and cervical cancer: An epidemiological study in Sweden. Cancer Res. Feb 1;76(3): 643-51.https://pubmed.ncbi.nlm.nih.gov/26634926/Flaherty RL, Owen M, Fagan-Murphy A, Intabli H, Healy D, Patel A, Allen MC, Patel BA, Flint MS. (2017) Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer. Breast Cancer Res. Mar 24;19(1):35.https://pubmed.ncbi.nlm.nih.gov/28340615/Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, Elbert T, Bürkle A, Kolassa IT.(2014) Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress.Psychotherapy and Psychosomatics.83(5):289-97.https://pubmed.ncbi.nlm.nih.gov/25116690/Bellis MA, Hughes K, Ford K, Ramos Rodriguez G, Sethi D, Passmore J. (2019) Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis. Lancet Public Health. Oct;4(10): e517-e528.https://pubmed.ncbi.nlm.nih.gov/31492648/Ziegler C, Richter J, Mahr M, Gajewska A, Schiele MA, Gehrmann A, Schmidt B, Lesch KP, Lang T, Helbig-Lang S, Pauli P, Kircher T, Reif A, Rief W, Vossbeck-Elsebusch AN, Arolt V, Wittchen HU, Hamm AO, Deckert J, Domschke K. (2016). MAOA gene hypomethylation in panic disorder: Reversibility of an epigenetic risk pattern by psychotherapy. Transl Psychiatry. Apr 5;6(4):e773. doi: 10.1038/tp.2016.41https://pubmed.ncbi.nlm.nih.gov/27045843/Roberts S, Lester KJ, Hudson JL, Rapee RM, Creswell C, Cooper PJ, Thirlwall KJ, Coleman JR, Breen G, Wong CC, Eley TC. (2014). Serotonin transporter [corrected] methylation and response to cognitive behavior therapy in children with anxiety disorders. Transl Psychiatry. Sep 16;4(9):e444.https://pubmed.ncbi.nlm.nih.gov/25226553/Roberts S, Keers R, Breen G, Coleman JRI, Jöhren P, Kepa A, Lester KJ, Margraf J, Scheider S, Teismann T, Wannemüller A, Eley TC, Wong CCY. (2019). DNA methylation of FKBP5 and response to exposure-based psychological therapy. Am J Med Genet B Neuropsychiatr Genet. Mar;180(2):150-158.https://pubmed.ncbi.nlm.nih.gov/30334356/Levy-Gigi E, Szabó C, Kelemen O, Kéri S. (2013).Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy. Biol Psychiatry. Dec 1;74(11): 793-800. doi: 10.1016/j.biopsych.2013.05.017https://pubmed.ncbi.nlm.nih.gov/23856297/Quidé Y, Witteveen AB, El-Hage W, Veltman DJ, Olff M. (2012). Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: A systematic review. Neurosci Biobehav Rev. Jan;36(1): 626-44.https://pubmed.ncbi.nlm.nih.gov/21963442/Bossini L, Santarnecchi E, Casolaro I, Koukouna D, Caterini C, Cecchini F, Fortini V, Vatti G, Marino D, Fernandez I, Rossi A, Fagiolini A. (2017). Morphovolumetric changes after EMDR treatment in drug-naïve PTSD patients. Riv Psichiatr. Jan-Feb;52(1): 24-31.https://pubmed.ncbi.nlm.nih.gov/28287194/Aizer AA, Chen MH, McCarthy EP, et al. Marital status and survival in patients with cancer. (2013) J Clin Oncol. 31: 3869‐3876.https://pubmed.ncbi.nlm.nih.gov/24062405/Mirosevic S, Jo B, Kraemer HC, Ershadi M, Neri E, Spiegel D. (2019). "Not just another meta-analysis": Sources of heterogeneity in psychosocial treatment effect on cancer survival. Cancer Med. Jan;8(1): 363-373.https://pubmed.ncbi.nlm.nih.gov/30600642/https://www.health.harvard.edu/heart-health/the-genetics-of-heart-disease-an-updateLevin M (2019) The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition. Front. Psychol. 10:2688.https://pubmed.ncbi.nlm.nih.gov/31920779/

Hear the Incredible Rob Berkley : His final interview

Rob Berkley left this earth in December 2019 as a result of cancer. 58. Rob was THE most empathic and warm-hearted individual in the entire marketing space (I’m not exaggerating). When you would sit down with him you would feel his warmth focusing on you like an infrared heat lamp. He was one of my most valuable business advisors. Being trained by him and Victor Cheng was like having Oprah and Stephen Hawking together in the same room.Stormy weather nearly prevented me from making his memorial at Martha’s Vineyard, but I managed to snag the boat ride and I’ll never forget the December 18 solstice sun streaming through the windows at his somber yet joyful gathering.The other thing I will never forget is meeting his wife Debbie for the first time, right there at his memorial service. I had heard much about her, and she had heard about me, but we had never crossed paths.I approached her in their kitchen and introduced myself. “Perry! I am so delighted to meet you!” She faced me squarely, looked deep into my eyes, and connected, human to human. I instantly felt the jolt of her conviction and aliveness. She wrapped her arms around me, embraced me, and welcomed me as though I were a friend of 25 years. Her energy was so palpable I was momentarily startled.It only makes sense that Rob would marry a woman like Debbie.Today I would like to share Rob’s last interview with you: a very candid conversation between Rob, Debbie, and their caregiver and collaborator Meredith, describing humility and courage in the face of a terminal diagnosis.