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3.2 Antimicrobial discovery and drug development
Season 3, Ep. 2
How do we develop drugs like antibiotics? How long does it take for such a drug to go from its inception in a research lab to use in a hospital, for example? And what people and processes are involved?
In this episode, we speak to microbiologist Dr. Vicky Savage, from INFEX Therapeutics, and Professor Colm Leonard at NICE. We look at every step of the drug development process, including drug procurements, applications, and the variety of uses within the healthcare system.
Hosted by Dr. Alex Lathbridge.
Produced by Hiren Joshi and Lizzy Ratcliffe.
7. 3.7 Will anti-fungal resistance lead to a Last of Us apocalypse?36:55Will climate change accelerate fungal threats to food and people? Will fungal infections cause a zombie apocalypse? How real is the science behind 'The Last of Us'? In this bonus episode, Manchester University’s Dr. Norman Van Rhijn, an expert on fungi, told the Brought To You By Chemistry podcast that the fight against antifungal resistance is constant, with some species evolving to defeat them in weeks. There is evidence that climate change is accelerating this fungal evolution, with some treatments used to combat fungal infections in crops overcome in as little as a month of exposure. What does this mean for global food security? Hosted by Hiren Joshi. Produced by Hiren Joshi.
6. 3.6 What do the challenges of AMR look like globally? Ft Professor Dame Sally Davies01:05:20In a perfect world, what should governments be doing to help prevent AMR? What are the political obstacles in the way of tackling AMR?In our final episode of the series, we speak to Professor Dame Sally Davies, Former UK Chief Medical Officer, Dr Eduardo Samo Gudo, Deputy Director General of the National Institute of Health in Mozambique. We also go around the world and speak with a variety of international experts to gain holistic insight into the challenges we face with AMR globally. From Government officials to academic experts, how can humanity come together to find solutions to antimicrobial resistance?Hosted by Dr. Alex Lathbridge. Produced by Hiren Joshi and Lizzy Ratcliffe.
5. 3.5 Infection prevention and control37:27How do we avoid getting to the point of needing to use so many antibiotics?Professor Morgan Alexander, Professor of Biomaterials at the University of Nottingham and Dr Lena Ciric, who leads the Healthy Infrastructure Research Group at University College London, join us for this episode on infection prevention and control. We learn about how diseases spread, especially through buildings and on surfaces, and how scientists are innovating to combat these mechanisms.Hosted by Dr. Alex Lathbridge.Produced by Hiren Joshi and Lizzy Ratcliffe.
4. 3.4 How does antimicrobial resistance impact our environment?50:59Why should we care about antibiotics being in the environment? How does it impact us? And what do we mean by "One Health"?In this episode we talk to Professor Barbara Kasprzyk, researcher from the University of Bath, Kurt Arden from the Royal Veterinary College and University College London, and Professor David Graham, Professor of Ecosystems Engineering at Newcastle University, who talk us through how antimicrobials get into the environment via our livestock and agriculture sectors, and why this is a problem.Hosted by Dr. Alex Lathbridge.Produced by Hiren Joshi and Lizzy Ratcliffe.
3.5. 3.3.5 Do the public need to be more scientifically literate? | With Dr. Hilary Jones26:44Why is it important to have Doctors working within the media? Do the public need to be more scientifically literate? What advances have we seen in diagnostics? And how can this help GPs in the UK?In this bonus episode, RSC producers Hiren Joshi & Lizzy Ratcliffe speak in depth with ITV's favourite GP - Dr. Hilary Jones. Dr. Hilary shares 40 years worth of medical wisdom, his experience working in the media, and reflects on the medical challenges present in antimicrobial resistance.Produced by Hiren Joshi and Lizzy Ratcliffe.
3. 3.3 The importance of diagnostics in fighting antimicrobial resistance (ft Dr. Hilary Jones)44:10Why is accurate diagnosis of patients so crucial in the fight against AMR? How do diagnostics work now and what is the best-case scenario in the future? What innovative technologies are being developed?Diagnostics is a key area in the fight against AMR since it's only through accurately diagnosing patients that the most targeted treatment can be chosen. Without accurate diagnostics, overprescription of antibiotics becomes inevitable. Professor Tina Joshi, Professor of Microbiology at Plymouth University, and Dr. Kaamini Walia of the India Council for Medical Research talk us through this important topic.This episode also features presenter and doctor Dr. Hilary Jones, with a fascinating insight into the challenges faced by GPs when prescribing antibiotics, and a deep-dive into the relationship between patients and medicine.Hosted by Dr. Alex Lathbridge.Produced by Hiren Joshi and Lizzy Ratcliffe.
1. 3.1 Introduction to antimicrobial resistance49:14What is AMR and why is it such an urgent challenge? What are researchers and governments doing to address it and what needs to done?In this episode, host Dr. Alex Lathbridge explores these questions with Professor Alison Holmes – president of the International Society for Infectious Diseases and researcher at Imperial College London, and Dr. Gerry Wright – researcher at McMasters University.Hosted by Dr. Alex Lathbridge.Produced by Hiren Joshi and Lizzy Ratcliffe.
8. 2.8 Batteries of the future41:35What are the exciting new technologies that we can look forward to in a future where batteries are front and centre?Dr. Mauro Pasta, Associate Professor of Materials at the University of Oxford, and Isobel Sheldon, commercial strategy officer for Britishvolt, join us to talk about the cutting-edge technologies that they are working on right now, as well as give us a sneak peek into what the future for batteries might look like.Hosted by Dr. Alex Lathbridge.Produced by Hiren Joshi and Lizzy Ratcliffe.