{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/e421d786-ec36-4148-aa99-7a3b2928a779/6a85c457a835875d37a7db87?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"Why a wakefulness drug is pharma's latest obsession","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/62e286a934d4d9fe5e874247/1787151305901-bbac6106-7aeb-4361-bfd6-f676bbf7d722.jpeg?height=200","description":"<p>A drug has been approved to treat narcolepsy, an excessive-sleepiness disorder. The new agonist mimics the action of <a href=\"https://www.economist.com/science-and-technology/2026/08/11/the-brain-may-be-about-to-have-its-ozempic-moment?utm_campaign=a.io&amp;utm_medium=audio.podcast.np&amp;utm_source=babbage&amp;utm_content=discovery.content.anonymous.tr_shownotes_na-na_article&amp;utm_term=sa.listeners\" rel=\"noopener noreferrer\" target=\"_blank\">orexin</a>, a neurotransmitter which helps to keep people awake. Inspired by the success of GLP-1 diabetes-turned-weight-loss jabs, researchers hope that targeting the orexin system might one day help people with other brain-related ailments, too.</p><p><br></p><p>Guests and hosts:</p><ul><li>Shailesh Chitnis, <em>The Economist</em>’s global business writer</li><li>Yanagisawa Masashi of the University of Tsukuba</li><li>Guy Leschziner of Guy’s and St Thomas’ Hospitals, London</li><li>Harry Fagan of the University of Southampton</li><li>Alex Hern, <em>The Economist</em>’s AI writer</li></ul><p><br></p><p>Topics covered:</p><ul><li>Orexin agonists and antagonists</li><li>Sleep disorders</li><li>Psychiatry&nbsp;</li></ul><p><br></p><p>Transcripts of our podcasts are available via <a href=\"http://economist.com/podcasts\" rel=\"noopener noreferrer\" target=\"_blank\">economist.com/podcasts</a>.</p><p><br></p><p>Listen to what matters most, from global politics and business to science and technology—<a href=\"https://subscribenow.economist.com/podcasts-plus\" rel=\"noopener noreferrer\" target=\"_blank\">subscribe to <em>The Economist</em></a>.</p>","author_name":"The Economist"}