{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/8b2badc5-1da9-5028-b83e-0e70fbd78a6f/62aabc1f7c3e450012bca3e0?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/61b9b44742e856733a985774/show-cover.png?height=200","description":"<p>June 2022</p><p><br></p><p>The papers behind the pod: </p><p><br></p><ol><li>Williams WO and Baneux P (2022).&nbsp;Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes.&nbsp;<em>Laboratory Animals</em>, in press.&nbsp;<a href=\"https://doi.org/10.1177%2F00236772221090801\" rel=\"noopener noreferrer\" target=\"_blank\">https://doi.org/10.1177/00236772221090801</a> </li><li>Osorio D&nbsp;<em>et al.&nbsp;</em>(2022). scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation.&nbsp;<em>Patterns</em>&nbsp;3(3): e100434.&nbsp;<a href=\"https://doi.org/10.1016/j.patter.2022.100434\" rel=\"noopener noreferrer\" target=\"_blank\">https://doi.org/10.1016/j.patter.2022.100434</a></li><li>Moudio S&nbsp;<em>et al.&nbsp;</em>(2022). Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease.&nbsp;<em>Frontiers in Neurology</em>&nbsp;13: e826102.&nbsp;<a href=\"https://doi.org/10.3389/fneur.2022.826102\" rel=\"noopener noreferrer\" target=\"_blank\">https://doi.org/10.3389/fneur.2022.826102</a></li></ol><p>&nbsp;</p><p>It’s the third Thursday of June, and you’re listening to 3 Minute 3Rs, your monthly recap of efforts to replace, reduce and refine the use of animals in research. Follow this link for the full transcript: </p><p><a href=\"https://nc3rs.org.uk/3-minute-3rs-podcast-june-2022-transcript\" rel=\"noopener noreferrer\" target=\"_blank\">https://nc3rs.org.uk/3-minute-3rs-podcast-june-2022-transcript</a></p>","author_name":"The NC3Rs, the North American 3Rs Collaborative, and Lab Animal"}