{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/69c1494f3bbfcfe8db5c89b2/6abda92c56d8e12f09f4d10b?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"Fasting-mimicking diets: Medical therapy or anti-aging hack?","description":"<p>882. Someone in your office comes back from vacation with a box of soups and shakes and announces they&#39;re doing a five-day fast. Except they&#39;re eating.</p><p>Fasting-mimicking diets are unusual among viral wellness protocols in that there is a real body of peer-reviewed research behind them. There is also a company selling the five-day kits, founded by the researcher who developed the protocol and funding many of the trials. Both of those things are true at the same time.</p><p><br></p><p>In this episode, Monica breaks down what the research actually shows:</p><ul><li>What the five-day protocol involves, including the calorie targets and why it&#39;s deliberately low in protein</li><li>What &quot;fasting mimicking&quot; means, and which effects of a multi-day fast it&#39;s trying to reproduce</li><li>The 2017 trial in 100 healthy adults, where participants lost about five and a half pounds over three months but saw no change in blood sugar, cholesterol, blood pressure, or inflammation</li><li>Why the subgroup findings are interesting and why they aren&#39;t proof</li><li>The 12-month trial in people with type 2 diabetes, where 40% reduced their diabetes medication compared with 5% in usual care</li><li>What the cancer research has shown in mice, what it hasn&#39;t yet shown in people, and why anyone in treatment needs their oncology team in the conversation first</li><li>Why the claim that five days can make you two and a half years biologically younger is the weakest part of the evidence, and what happened to the third of participants whose scores got worse</li><li>Whether you can replicate the protocol without buying a branded kit, and what you might be giving up if you do</li><li>What the dropout rates in these studies say about how doable this really is</li></ul><p><br></p><p>New to Nutrition Diva? Check out our special <a href=\"https://open.spotify.com/playlist/59vwhJqu3bTvSCRsXmbqY6\" rel=\"noopener noreferrer\" target=\"_blank\">Spotify playlist</a> for a collection of the best episodes curated by our team and Monica herself!</p><p>Follow Nutrition Diva on <a href=\"https://facebook.com/qdtnutrition\" rel=\"noopener noreferrer\" target=\"_blank\">Facebook</a> and <a href=\"https://www.quickanddirtytips.com/nutrition-diva-newsletter\" rel=\"noopener noreferrer\" target=\"_blank\">subscribe to the newsletter</a> for more diet and nutrition tips.</p><p>Find out about Monica&#39;s keynotes and other programs at <a href=\"https://wellnessworkshere.com/\" rel=\"noopener noreferrer\" target=\"_blank\">WellnessWorksHere.com</a></p><p>Nutrition Diva is a part of the<a href=\"https://quickanddirtytips.com/\" rel=\"noopener noreferrer\" target=\"_blank\"> Quick and Dirty Tips</a> podcast network.</p><p><br></p><p><strong>Related Episodes </strong></p><p><a href=\"https://shows.acast.com/69c1494f3bbfcfe8db5c89b2/69c14959007cdcf83fc1b8e6\" rel=\"noopener noreferrer\" target=\"_blank\">788: intermittent fasting</a></p>","author_name":"QuickAndDirtyTips.com, Monica Reinagel, MS, LDN"}