Aimee Donnellan joins Laura to talk about her new book Off the Scales: The Inside Story of Ozempic and the Race to Cure Obesity, and the much bigger story sitting underneath it - how generations of women learned to live with food.
Through interviews with women across the world, Aimee found the same pattern repeating. A trip to a dietitian around the age of seven. A mother quietly carrying her own dieting story, passing it on through Weight Watchers, rice cakes and \"don't think cute clothes mean you can come off your diet.\" For some, GLP-1 medications like Wegovy and Mounjaro have quietened the food noise for the first time in their lives. For others, the more confronting realisation is how differently the world treats them when they shrink.
Aimee also explores how the men in her book relate to their bodies very differently, the rising scale of childhood obesity and the shame attached to it, and why the food industry has barely adjusted to a world where appetite itself is shifting. She and Laura reflect on body positivity, menopause and the pressure women carry at every stage of life, before closing on something simpler - why she thinks the meaning of life comes down to picking up the phone.
1. Dieting often starts in childhood — Many of the women Aimee spoke to were first sent to a dietitian around age seven, framing food as something to manage rather than enjoy.
2. Mothers carry the story forward — Weight Watchers, calorie counting and \"good\" and \"bad\" foods pass quietly from mother to daughter across generations.
3. Food noise can dominate a life — Constant thoughts about food and shame-based self-talk shape how many women move through the world.
4. GLP-1 drugs change more than weight — When the food noise quietens, work, relationships, shopping and how others treat you can all shift.
5. Men and women relate to weight differently — Men often seek treatment for health reasons, while women carry decades of body criticism and comparison.
6. These drugs are not a quick fix — Muscle loss, side effects, cost and the reality of injecting long-term are rarely talked about honestly.
7. Childhood obesity is rising — Shame and clinics that don't fit larger bodies stop many families seeking help early.
8. The food industry has barely adjusted — Cheap, ultra-processed food still fills shelves, and meaningful change runs into cost and lobbying.
Off the Scales: The Inside Story of Ozempic and the Race to Cure Obesity — Aimee Donnellan
01:00 — Welcome and the focus of the book
03:00 — Why the dieting story starts at age seven
04:30 — Rice cakes, Hershey's sauce and a mother's diet
06:00 — Sarah's first Wegovy injection
07:00 — Losing 70 pounds and a life that changes overnight
12:00 — Menopause, microdosing and Ozempic on the black market
14:00 — Body positivity, celebrity bodies and the shift back
22:00 — Plateaus, muscle loss and life-long drugs
28:00 — A Mars executive on a pharma board
36:00 — How men relate to their bodies differently
41:00 — Childhood obesity, shame and small clinic rooms
44:00 — Food deserts and the cost of real change
56:00 — Picking up the phone and choosing connection
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