In this episode of the Laura Dowling Experience, Matt Kaeberlein, a global leader in ageing science, discusses his mission to help people and animals live longer and healthier lives by modifying the biological mechanisms of ageing. Matt, CEO of Optisan, a healthcare technology company, talks about his transition from academia to entrepreneurship and highlights the importance of lifestyle factors—nutrition, exercise, sleep, and social connection—in maximising health span. The conversation explores emerging approaches to longevity, including hormone therapy, therapeutic plasma exchange, and the use of drugs such as rapamycin and SGLT2 inhibitors. Matt shares personal experiences with ageing-related health strategies and offers valuable insights into the role of love and altruism in achieving a fulfilling life.
02:48 – Introduction: Meet Matt Kaeberlein, global leader in ageing science
03:13 – What does Matt Kaeberlein do? Biological mechanisms of ageing
04:40 – The concept of health span vs. lifespan
06:55 – Four pillars of health span: Eat, Move, Sleep, Connect
09:04 – The importance of human and animal connection
11:06 – Beyond lifestyle: Hormones and health span
16:06 – Menopause, HRT, and women’s health
24:55 – Testosterone therapy for men: Risks and benefits
31:35 – Alcohol, lifestyle, and longevity
34:34 – Environmental exposures: Heavy metals, microplastics, and health
39:44 – Therapeutic plasma exchange and ageing research
47:09 – Rapamycin: The science, trials, and potential for longevity
59:46 – Diet, fasting, and inflammation: What Matt Kaeberlein eats
1:07:32 – Continuous glucose monitoring and behaviour change
1:14:07 – SGLT2 inhibitors and other promising drugs
1:19:07 – Final advice: Choose love, not fear; the meaning of life
","author_name":"Laura Dowling"}