The question this community has been asking since nsPFA first appeared on this podcast has finally been answered.
Does it last?
Professor Stefano Spiezia conducted the first-in-human feasibility study of nsPFA for benign thyroid nodules — and in 2026 he presented the durability data at the NASIT annual meeting in Portland, Oregon. Average 74% volume reduction at up to 22 months. Zero regrowth. Zero serious adverse events. And the nodule continued to shrink throughout the entire follow-up period.
Professor Spiezia is the Head of the Division of Endocrine and Ultrasound Guided Surgery at the Sea Hospital in Naples, Director of the Regional Reference Center for Thyroid Treatment, Adjunct Professor at the University of Turin, and Director of the Save Your Thyroid International School for Interventional Thyroid Procedures.
In this episode:
✅ Why nsPFA is a paradigm shift — not just another energy source
✅ How it works — programming cells to die, not burning them
✅ The 22-month durability data — 74% volume reduction, zero regrowth, zero serious adverse events
✅ Why the nodule kept shrinking throughout the entire follow-up
✅ 100% patient satisfaction with cosmetic appearance, 95% overall
✅ Why the absence of fibrosis and scarring changes everything
✅ Which nodules benefit most — especially those near critical structures
✅ Why nsPFA and RFA are complementary rather than competitive
✅ The regulatory landscape — FDA cleared in the US, CE mark pending in Europe
✅ The Save Your Thyroid International School — training physicians worldwide
If you have been waiting for the durability data on nsPFA before making a decision — this is the episode you have been waiting for.
Chapters
00:00 Introduction to Thyroid Nodule Treatments
01:04 New chapter
01:57 The Evolution of Non-Surgical Options
03:56 Understanding NSPFA: A Paradigm Shift
03:56 The Safety and Efficacy of NSPFA
15:39 Navigating Thyroid Nodule Diagnosis
44:09 Introduction to the Podcast and Resources
44:09 Navigating Thyroid Health and Community Support
🔗 Professor Spiezia & the Save Your Thyroid International School:
www.sytmedical.com
🔗 nsPFA Trial at MD Anderson & Sarasota Memorial (NCT07218315):
clinicaltrials.gov/study/NCT07218315
Contact: (941) 917-2225 or researchinstitute@smh.com
📌 Resources:
👉 Podcast: https://www.saveyourthyroidwithjen.com/
👉 Patient site: https://www.saveyourthyroid.org/
👉 Private FB group: https://www.facebook.com/groups/saveyourthyroidnonsurgical
👉 Patient Navigation: https://www.saveyourthyroidwithjen.com/patient-navigation-services/
⚠️ Disclaimer:
This podcast is for informational purposes only and is not a substitute for professional medical advice. No endorsement is given or implied for any specific product, treatment, or physician mentioned. Always consult with a qualified healthcare professional regarding your individual medical needs.
🎵 Music licensed through Soundstripe:
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