{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/66f0401ae9120d670fedc122/691dc202cce7a2a565bc1901?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"Systemic Lupus Erythematosus (SLE)","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/66f0401ae9120d670fedc122/1763557854530-2126fbe4-d942-4ba2-b203-d72ec40655cb.jpeg?height=200","description":"<p>This episode is a comprehensive overview of Systemic Lupus Erythematosus (SLE), an autoimmune disease where the immune system attacks the body’s own tissues. </p><p><br></p><p>We detail the pathogenesis of SLE, focusing on complex immune-related mechanisms, such as the roles of the complement system, autoantibodies like anti-C1q and anti-dsDNA, and the dysfunction of Neutrophil Extracellular Traps (NETs). </p><p><br></p><p>We also examine how metabolic irregularities, specifically dyslipidemia and alterations in lipid and glucose metabolism within immune cells, contribute to disease development and associated complications like cardiovascular issues and lupus nephritis. </p><p><br></p><p>#LupusAwareness #AutoimmuneDisease #SLE #ImmuneSystem #LupusNephritis #medicalpodcast</p>","author_name":"Josh and Anna"}