{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/65736d39d32e730012c98919/6895001a7f93fda8b2fae8a9?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"Reversing Parkinson’s in Mice, Protecting Primates from HIV, Top 10 Biotech Clusters, and Sarepta","description":"<p>This episode of&nbsp;<em>GEN</em>'s <em>Touching Base</em> spotlights the unexpected relationship between breathing low oxygen and restoration of neuron function in a mouse model of Parkinson’s disease. In addition, a&nbsp;single gene therapy injected&nbsp;at birth now offers lasting protection from HIV in infant rhesus macaques. Rounding out our episode, we discuss key factors shaping this year’s A-List of Top 10 U.S. Biopharma Clusters and recap the regulatory conflict surrounding Sarepta Therapeutics’ Duchenne muscular dystrophy (DMD) gene therapy, Elevidys®—including the departure of Vinay Prasad, MD, the FDA official behind the agency’s brief get-tough approach.</p><p><br></p><p>Join <em>GEN</em> editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.&nbsp;</p><p><br></p><p>Listed below are links to the <em>GEN</em> stories referenced in this episode of <em>Touching Base</em>:</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/translational-medicine/glp-1-drug-semaglutide-linked-to-reduced-muscle-strength-in-mice/\" rel=\"noopener noreferrer\" target=\"_blank\">GLP-1 Drug Semaglutide Linked to Reduced Muscle Strength in Mice</a></p><p><em>GEN,</em> August 6, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/drug-discovery/out-of-thin-air-hypoxia-reverses-parkinsons-symptoms-in-mice/\" rel=\"noopener noreferrer\" target=\"_blank\">Out of Thin Air: Hypoxia Reverses Parkinson’s Symptoms in Mice</a></p><p>By Fay Lin, PhD <em>GEN,</em> August 6, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/news/early-gene-therapy-provides-lasting-hiv-protection-in-newborn-primates/\" rel=\"noopener noreferrer\" target=\"_blank\">Early Gene Therapy Provides Lasting HIV Protection in Newborn Primates</a></p><p><em>GEN,</em> July 30, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/genome-editing/stockwatch-as-prasad-exits-fda-analysts-see-benefit-for-sarepta-cgt-stocks/\" rel=\"noopener noreferrer\" target=\"_blank\">StockWatch: As Prasad Exits FDA, Analysts See Benefit for Sarepta, CGT Stocks</a></p><p>By Alex Philippidis, <em>GEN Edge,</em> August 3, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/genome-editing/sarepta-to-resume-shipping-dmd-gene-therapy-to-ambulant-patients/\" rel=\"noopener noreferrer\" target=\"_blank\">Sarepta to Resume Shipping DMD Gene Therapy to Ambulant Patients</a></p><p>By Alex Philippidis, <em>GEN Edge,</em> July 28, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/drug-discovery/sarepta-under-scrutiny-astrazenecas-big-bet-and-ai-vs-idrs/\" rel=\"noopener noreferrer\" target=\"_blank\">Sarepta Under Scrutiny, AstraZeneca’s Big Bet, and AI vs. IDRs</a></p><p>By Alex Philippidis, Uduak Thomas, Fay Lin, PhD, Corinna Singleman, PhD, <em>GEN,</em> July 25, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/topics/genome-editing/about-face-sarepta-to-pause-elevidys-shipments-temporarily/\" rel=\"noopener noreferrer\" target=\"_blank\">About Face: Sarepta to Pause Elevidys Shipments Temporarily</a></p><p>By Alex Philippidis, <em>GEN Edge,</em> July 21, 2025</p><p><br></p><p><a href=\"https://www.genengnews.com/category/multimedia/podcasts/touching-base/\" rel=\"noopener noreferrer\" target=\"_blank\">Touching Base Podcast</a></p><p>Hosted by Corinna Singleman, PhD</p><p><br></p><p><a href=\"https://www.insideprecisionmedicine.com/category/multimedia/podcasts/\" rel=\"noopener noreferrer\" target=\"_blank\">Behind the Breakthroughs</a></p><p>Hosted by Jonathan D. Grinstein, PhD</p><p><br></p><p><a href=\"https://webinars.liebertpub.com/e/the-state-of-biotech-2025\" rel=\"noopener noreferrer\" target=\"_blank\">The State of Biotech Summit Registration</a></p>","author_name":"Genetic Engineering & Biotechnology News (GEN)"}