{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/655b7c0c64b708001285b256/6a6771c3c02856ded19301fd?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"How Ketones Boost Brain and Body Health | Dr Mark Mattson","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/655b7c0c64b708001285b256/1785164184023-a4744dca-26dd-4309-8ac7-bac01eb95da4.jpeg?height=200","description":"<p>Dr. Mark Madsen discusses the science behind intermittent fasting, ketosis, and their effects on health, aging, and brain function. He explores mechanisms like BDNF, autophagy, and evolutionary perspectives on stress responses.</p><p><br></p><p>Key Topics</p><p><br></p><p>- Mechanisms of fasting benefits: calorie restriction, glycation, inflammation</p><p>- Role of ketones as signaling molecules and energy sources</p><p>- BDNF and brain plasticity</p><p>- Exogenous ketones and athletic performance</p><p>- Evolutionary perspective on stress and adaptation</p><p><br></p><p>Chapters</p><p><br></p><p>00:00 Introduction and guest introduction</p><p>00:11 Ben's fasting experiments and Ori Hoffmeckler influence</p><p>01:13 Are fasting benefits due to calorie restriction or other mechanisms?</p><p>01:31 Experimental evidence on fasting and lifespan extension in mice</p><p>02:30 Human study on 5-2 fasting and metabolic health</p><p>05:27 Benefits of fasting beyond calorie restriction</p><p>07:11 Fasting, ketosis, and athletic performance</p><p>08:10 Second wind phenomenon and metabolic flexibility</p><p>09:16 Fasting and metabolic health in athletes like Matthew Pinson</p><p>10:25 Exogenous ketones and their role in health and performance</p><p>16:02 BDNF, brain health, and the effects of ketones</p><p>19:10 Evolutionary perspective on brain and body adaptation</p><p>20:23 Stress response, autophagy, and cellular health</p><p>25:47 Exercise, challenge, and brain resilience</p><p>27:50 Lifestyle, obesity, and cognitive health</p><p>28:34 The importance of stress and challenge in evolution</p><p>43:31 Impact of media and public awareness on fasting science</p><p>45:28 Clinical trials and health benefits of intermittent fasting</p><p>46:26 Healthcare system, prevention, and societal challenges</p><p>48:23 Barriers to healthy lifestyle and socioeconomic factors</p><p>49:10 Diet, supplements, and natural chemicals in health</p><p>53:22 Neuroendocrinology and brain development</p><p>54:30 Neurotransmitters, glutamate, and neural wiring</p><p>56:26 Excitotoxicity and neural damage in disease</p><p>58:00 Dietary chemicals and adaptive stress response</p><p>01:02:59 Evolutionary mechanisms of plant chemicals and human health</p><p>01:04:58 Dose, duration, and frequency of stressors</p><p>01:06:06 Optimal intermittent fasting patterns and research challenges</p><p>01:07:41 Connecting lifestyle, stress, and evolutionary biology</p><p><br></p><p><br></p><p>Mark Madsen's Institute - https://matsonianinstitute.org</p><p>Brain Ponderings Podcast - https://matsonianinstitute.org/podcast</p><p><br></p><p>Website - https://matsonianinstitute.org</p><p>Podcast - https://matsonianinstitute.org/podcast</p><p><br></p><p>-------------------------------------------------------------------------------------------------------------------------</p><p><br></p><p><br></p><p>🌈 Exploring the benefits of red and infra light therapy? Our community receive 10% off the FlexBeam from Recharge Health via this link: ⬇️</p><p>https://rechargehealthas.sjv.io/DyJ3mn (learn more about the benefits of healing with light in our 'Light as Medicine' Playlist).</p><p><br></p><p>🤝 Join the community - by subscribing, you are self-selecting as a health nerd. We like you. We applaud you. You are shaping in real time the future of health information. As a thank you, we pledge to bring you the best we can, where we are, with the tools we have.</p><p><br></p><p>🎧 Listen to us on-the-go! Available wherever you listen to your favourite podcasts. New episode every Wednesday!</p><p><br></p><p><br></p>","author_name":"Benjamin Hopkins"}