In this episode, Ben Hopkins sits down with longevity scientist Professor Matt Kaeberlein to unpack the biggest questions in aging, health span, and the science of living longer.
They cover the promise and pitfalls of biological age clocks, why resveratrol failed to live up to the hype, how to think about aging as entropy and resilience, and which interventions actually look promising today. Matt also explains where lifestyle, hormones, and medications like rapamycin, SGLT2 inhibitors, GLP-1 agonists, and more fit into a practical longevity strategy.
If you’re interested in evidence-based longevity, proactive health, and the future of aging research, this conversation is packed with insights.
00:00 Intro
00:37 Are biological age clocks a breakthrough or a gimmick?
06:04 What is aging, really?
11:25 Resveratrol: signal or noise?
21:58 The biggest proven levers for health and lifespan
27:25 SGLT2 inhibitors, GLP-1s, and proactive medicine
38:28 Testosterone, hormones, and aging
51:01 Why rapamycin has been so misunderstood
55:13 Compound bets: what’s most promising?
60:50 What surprised Matt most in longevity science?
63:58 The Dog Aging Project and longevity research in dogs
Learn more about Matt’s work on the Dog Aging Project and Dog Aging Institute, and check out his podcast and research updates for more on the science of longevity.
If you enjoyed this conversation, please like, subscribe, and share it with someone who would benefit from learning more about women's metabolic health.
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