Dr Adrian Soto-Mota, MD, PhD is one of the clearest and most curious voices in metabolic research and he’s not afraid to say what doesn’t make sense anymore.
Dr Adrian is an internal medicine physician and metabolic researcher based in Mexico City. In this conversation, we go deep on the limitations of RCTs, why calorie logic keeps breaking down, what lean mass hyper-responders teach us about lipids, and why sometimes the data works before we understand the mechanism.
We also talk about the surprising impact of meat-heavy diets on IBD, why exogenous ketones matter more than people think and how metabolic dysfunction might be sitting at the core of psychiatric illness.
This one is full of nuance and yet grounded in clinical reality.
We cover:
🧠 The metabolic demands of the human brain
💊 Why calories don’t predict fat gain the way we think
🧬 Lean mass hyper-responders and cholesterol interpretation
📉 Why nutritional RCTs can’t answer what we want them to
🧪 Hormones, definitions and broken language in medicine
🧘♂️ Metabolic psychiatry & the case for new mental health models
Find Adrian:
Mentioned in this episode:
Modeling Life by Alan Garfinkel
Bernoulli’s Fallacy by Aubrey Clayton
Rethinking Statistics by Richard McElreath
Human Metabolism by Keith Frayn & Rhys Evans
JAMA Psychiatry paper on metabolic dysfunction & mental illness
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