{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/64913e28-7031-4ea6-9bef-fddf46dfed87/f3f7c0b3-338b-4c88-9e42-3e78052fb059?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"#60 How to Reverse Ageing (Part 4 of 4). The Future of Longevity Research with Professor David Sinclair","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/613910d92449a85aeebc9e4c/1666865719590-9ac8ad3d8c6b79fdf8f769768ea7c84c.jpeg?height=200","description":"<p>My guest on the show today is&nbsp;<strong>David A. Sinclair, Ph.D</strong>, a tenured&nbsp;<strong>Professor of Genetics at Harvard Medical School</strong>, he is best known for his work on&nbsp;<strong>genes and small molecules that delay ageing</strong>, including the Sirtuins, NAD precursors, Resveratrol and other epigenetic modifiers.&nbsp;</p><p><br></p><p>He has received many honours including a feature on&nbsp;<strong>TIME magazine’s list of the “100 most influential people in the world”</strong>&nbsp;and this podcast episode about how to treat and reverse ageing will give you a glimpse into why he is so deserving.</p><p><br></p><p><strong>On the show we talk about:</strong></p><p><br></p><ul><li>The hallmarks of ageing and why to distinguish it as a disease</li><li>Instead of trying to tackle each one of the 8 central tenants of ageing, how Prof is looking at the epigenome</li><li>Sirtuins and their role in ageing, DNA repair and gene expression</li><li>AMPK, MTor, Sirtuins as regulators of lifespan and defence pathways</li><li>Methods of fighting ageing and activating the body’s natural defence systems</li><li>Energy restriction, aerobic exercise, sauna and cold shock therapy</li><li>energy restriction, exercise triggering hypoxia, sauna, cold shock therapy,</li><li>NAD and NAD precursors, Metformin, rapamycin and resveratrol as molecules that can improve ageing</li><li>Why we need to treat ageing like a disease, which forms the foundation of multiple diseases. If we cure ageing, we cure a lot.</li><li>The ethical considerations of increasing lifespan</li></ul><p>&nbsp;</p><p>Do check out David’s work and his latest book -&nbsp;<a href=\"https://lifespanbook.com/about-lifespan/\" rel=\"noopener noreferrer\" target=\"_blank\">Lifespan - Why We Age and Why We Don’t Have To.</a></p><p><br></p><p><strong>All other social media links are noted here below.</strong></p><p><br></p><p><a href=\"https://www.youtube.com/channel/UCwD5YYkbYmN2iFHON9FyDXg\" rel=\"noopener noreferrer\" target=\"_blank\">YouTube</a></p><p><a href=\" https://lifespanbook.com\" rel=\"noopener noreferrer\" target=\"_blank\">Website</a></p><p><a href=\"https://twitter.com/davidasinclair\" rel=\"noopener noreferrer\" target=\"_blank\">Twitter</a></p><p><a href=\"https://www.instagram.com/davidsinclairphd/?hl=en\" rel=\"noopener noreferrer\" target=\"_blank\">Instagram</a></p>","author_name":"Dr Rupy Aujla"}