{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/62d20dbcffef490011c8df4b/6a092b47bae3d7f66f49139f?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"201. Back to Basics - Advanced Gastric/GOJ Cancer","description":"<p>On today's episode, Josh and Michael \"advance\" in their ongoing GI journey, as Michael continuously insists on saying, to discuss advanced gastric and GOJ cancer. Historically an orphan disease with very poor prognosis, perhaps the first rays of light are beginning to shine on this difficult-to-treat cancer type. Immunotherapy has been well established as standard of care, but are there any new agents that are emerging in this space? As always, the answer to that question is \"yes,\" and as usual, the agent in question is trastuzumab deruxtecan. Listen on for all the surprising details, even more awful puns, and a strange tangent about the difference between a \"good\" and \"effective\" dictator.</p><p><br></p><p><strong>Studies discussed in this episode:</strong></p><p><a href=\"https://www.nejm.org/doi/full/10.1056/NEJMoa2111380\" rel=\"noopener noreferrer\" target=\"_blank\">Checkmate 648</a>/<a href=\"https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00797-2/fulltext\" rel=\"noopener noreferrer\" target=\"_blank\">649</a></p><p><a href=\"https://www.nejm.org/doi/full/10.1056/NEJMoa2004413\" rel=\"noopener noreferrer\" target=\"_blank\">Destiny-Gastric01</a></p><p><br></p><p>For more episodes, resources and blog posts, visit <a href=\"https://open.acast.com/networks/62d20dbcffef490011c8df4d/shows/62d20dbcffef490011c8df4b/episodes/www.inquisitiveonc.com\" rel=\"noopener noreferrer\" target=\"_blank\">www.inquisitiveonc.com</a></p><p>Please find us on Twitter <a href=\"https://open.acast.com/networks/62d20dbcffef490011c8df4d/shows/62d20dbcffef490011c8df4b/episodes/@InquisitiveOnc!\" rel=\"noopener noreferrer\" target=\"_blank\">@InquisitiveOnc!</a></p><p>If you want us to look at a specific trial or subject, email us at <a href=\"mailto:inquisitiveonc@gmail.com\" rel=\"noopener noreferrer\" target=\"_blank\">inquisitiveonc@gmail.com</a></p><p><br></p><p>Art courtesy of Taryn Silver</p><p>Music courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/</p><p><br></p><p>Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.</p><p><br></p><p>Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content.</p>","author_name":"Michael Fernando and Josh Hurwitz"}