{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/62d20dbcffef490011c8df4b/69e34d35d2febdbec9ec881f?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"197. Back to Basics - Metastatic Colorectal Cancer - HER2 positive disease and PI3K mutations","description":"<p>Metastatic Colorectal Cancer has a dearth of targetable mutations that have effective outcomes. This week, Michael and Josh see whether the wonder drug (trastruzumab deruxtecan) works in HER2-expressing colorectal cancer. Michael takes a more positive tone, with the recycling of aspirin to reduce recurrence risk for PI3K pathway cancers.</p><p><br></p><p>Josh promised he will have the right audio this episode - thanks to our astute listener who told us last time!</p><p><br></p><p><strong>Studies discussed in this episode:</strong></p><p><a href=\"https://ascopubs.org/doi/10.1200/JCO.2025.43.4_suppl.LBA125\" rel=\"noopener noreferrer\" target=\"_blank\">ALASCCA</a></p><p><a href=\"https://www.nature.com/articles/s41467-023-38032-4\" rel=\"noopener noreferrer\" target=\"_blank\">Destiny-CRC01</a></p><p><br></p><p>For more episodes, resources and blog posts, visit <a href=\"https://open.acast.com/networks/62d20dbcffef490011c8df4d/shows/62d20dbcffef490011c8df4b/episodes/www.inquisitiveonc.com\" rel=\"noopener noreferrer\" target=\"_blank\">www.inquisitiveonc.com</a></p><p>Please find us on Twitter <a href=\"https://open.acast.com/networks/62d20dbcffef490011c8df4d/shows/62d20dbcffef490011c8df4b/episodes/@InquisitiveOnc!\" rel=\"noopener noreferrer\" target=\"_blank\">@InquisitiveOnc!</a></p><p>If you want us to look at a specific trial or subject, email us at <a href=\"mailto:inquisitiveonc@gmail.com\" rel=\"noopener noreferrer\" target=\"_blank\">inquisitiveonc@gmail.com</a></p><p><br></p><p>Art courtesy of Taryn Silver</p><p>Music courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/</p><p><br></p><p>Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.</p><p><br></p><p>Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content.</p>","author_name":"Michael Fernando and Josh Hurwitz"}