{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/62d20dbcffef490011c8df4b/653afb9dab9fa20012954cea?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"72. ESMO 2023 - Early Breast Cancer (Part 2)","description":"<p>Welcome back to Oncology for the Inquisitive Mind's ongoing coverage of ESMO 2023. In the spirit of a worldwide oncology conference, here we present results from three very exciting trials in the early breast phase. Will immunotherapy begin to carve out a niche in early, high-risk, ER-positive breast cancer? Can atezolizumab demonstrate a benefit in early TNBC, and expand its own territory? Is abemaciclib pulling away from its rivals in the treatment of high-risk, ER-positive breast cancer? Will managing early breast cancer eventually have a similar success rate to the management of diabetes? And, most importantly, is Michelangelo a better Ninja Turtle than Donatello? The answers to all these questions, and more, lie within.</p><p><br></p><p>Studies discussed in this episode (subscription may be required):</p><ul><li>Adjuvant abemaciclib plus endocrine therapy for HR+, HER2-, high-risk early breast cancer: Results from a preplanned monarchE overall survival interim analysis, including 5-year efficacy outcomes</li><li><a href=\"https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639087\" rel=\"noopener noreferrer\" target=\"_blank\">https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639087</a></li><li>Event-free survival (EFS) analysis of neoadjuvant taxane/carboplatin with or without atezolizumab followed by an adjuvant anthracycline regimen in high-risk triple negative breast cancer (TNBC): NeoTRIP Michelangelo randomized study</li><li><a href=\"https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639109\" rel=\"noopener noreferrer\" target=\"_blank\">https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639109</a></li><li>A randomized, double-blind trial of nivolumab (NIVO) vs placebo (PBO) with neoadjuvant chemotherapy (NACT) followed by adjuvant endocrine therapy (ET) ± NIVO in patients (pts) with high-risk, ER+ HER2− primary breast cancer (BC)</li><li><a href=\"https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639073\" rel=\"noopener noreferrer\" target=\"_blank\">https://esmocongress.esmo.org/esmo/esmo2023/en-GB/presentation/639073</a></li></ul><p><br></p><p>For more episodes, resources and blog posts, visit <a href=\"https://open.acast.com/shows/62d20dbcffef490011c8df4b/episodes/www.inquisitiveonc.com\" rel=\"noopener noreferrer\" target=\"_blank\"><strong>www.inquisitiveonc.com</strong></a></p><p>Please find us on Twitter @InquisitiveOnc!</p><p>If you want us to look at a specific trial or subject, email us at<strong> </strong><a href=\"mailto:inquisitiveonc@gmail.com\" rel=\"noopener noreferrer\" target=\"_blank\"><strong>inquisitiveonc@gmail.com</strong></a></p><p><br></p><p>Art courtesy of Taryn Silver</p><p>Music courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/</p><p><br></p><p><strong>Disclaimer:</strong> This podcast is for educational purposes only. If you are unwell, seek medical advice.</p>","author_name":"Michael Fernando and Josh Hurwitz"}