Concluding their Journey to the Centre of the Brain, Michael and Josh tackle one of the most challenging and difficult cancers in modern oncology: high-grade gliomas. All of the usual suspects are here: irrevocable, progressive disease, limited treatment options and a gulf in evidence so large it makes the Grand Canyon look like a muddy footprint. All in all, not the most optimistic of OftiM episodes, but Josh and Michael will tackle it anyway so you don't have to. And remember: always refer your fit GBM patients to a friendly neighbourhood trials unit near you!
Links to studies discussed in this episode (subscription may be required):
EORTC 26981-22981 NCIC CE3 (aka the “Stupp study\"): https://www.nejm.org/doi/full/10.1056/nejmoa043330
RTOG 0825: https://www.nejm.org/doi/full/10.1056/nejmoa1308573
Brada et al: https://ascopubs.org/doi/full/10.1200/JCO.2009.27.1932?role=tab
Taal et al: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70314-6/fulltext
Wick et al: https://www.nejm.org/doi/full/10.1056/nejmoa1707358
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Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/
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