Lipopolyplex is a ternary complex of cationic liposome, polycation and nucleic acid. It is the second generation of non-viral gene vector developed after the first generation of cationic liposome complex. Specifically, mRNA molecules are encapsulated in a polymer core loaded into a phospholipid bilayer shell structure. The obtained structure can not only protect the mRNA molecules in the multi-node core structure from the attack of RNA enzyme, but also be internalized effectively by dendritic cells (DCs). In DCs, particles are transported through the vector system, and the mRNA molecules are released into the cytoplasm to generate antigens.
","author_name":"Jerry Carter"}