Nucleotides modifications affect a diversity of biological processes in the organisms. For instance, modifications (commonly N⁶-methyladenosine) in messenger RNA (mRNA) regulate various aspects, such as mRNA location, metabolism, stability, protein translation, even stem cell differentiation. Chemical modifications in tRNA and rRNA directly affect protein translation. In humans, these diverse modifications in RNAs are closely linked to some human disorders, such as tumors and cancers, neurological disorders, mitochondrial-linked diseases, and diabetes.
","author_name":"Jerry Carter"}