{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/5e8c1453f335f8fc5483e9ce/687c577ba2391fe432910232?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":" Is Methotrexate ready for clinical use? A discussion with Professor Robin Christensen and Dr Anna Dossing","description":"<p>Methotrexate is a well-established drug used in oncology, but could it also play a role in managing osteoarthritis? In this episode of Joint Action, Professor David Hunter is joined by Dr Anna Døssing and Professor Robin Christensen to explore the potential of methotrexate as a treatment for osteoarthritis pain.</p><p> </p><p>They discuss:</p><ul><li>What methotrexate is and how it works</li><li>Insights from a recent meta-analysis on its effectiveness and safety</li><li>Why individual studies show mixed results</li><li>Whether it might help people with hand or knee OA - especially those with signs of inflammation</li><li>How dosing and side effects factor into clinical decision-making</li></ul><p> </p><p>Tune in for an honest, data-driven conversation about repurposing an old drug for a new purpose - and what it could mean for people living with osteoarthritis.</p><p><br></p><p>RESOURCES</p><p><br></p><ul><li>Editorial: Methotrexate for osteoarthritis—Ready for clinical use and in whom?: <a href=\"https://www.oarsijournal.com/article/S1063-4584(25)00973-2/abstract?\" rel=\"noopener noreferrer\" target=\"_blank\">https://www.oarsijournal.com/article/S1063-4584(25)00973-2/abstract?</a></li></ul><p><br></p><p>CONNECT WITH US</p><p><br></p><ul><li>Twitter:&nbsp;<a href=\"https://twitter.com/ProfDavidHunter\" rel=\"noopener noreferrer\" target=\"_blank\">@ProfDavidHunter</a>&nbsp;<a href=\"https://twitter.com/jointactionorg\" rel=\"noopener noreferrer\" target=\"_blank\">@jointactionorg</a></li><li>Instagram: <a href=\"https://www.instagram.com/osteoarthritisresearchgroup/\" rel=\"noopener noreferrer\" target=\"_blank\">@osteoarthritisresearchgroup</a></li><li>Email:&nbsp;<a href=\"mailto:osteoarthritis.research@sydney.edu.au\" rel=\"noopener noreferrer\" target=\"_blank\">osteoarthritis.research@sydney.edu.au</a></li><li>Website:&nbsp;<a href=\"https://www.jointaction.info/podcast\" rel=\"noopener noreferrer\" target=\"_blank\">https://www.jointaction.info/podcast</a></li></ul><p><br></p>","author_name":"David Hunter, PhD, FRACP (Rheum)"}